PMID- 34853295 OWN - NLM STAT- MEDLINE DCOM- 20220202 LR - 20220202 IS - 2044-5385 (Electronic) IS - 2044-5385 (Linking) VI - 11 IP - 12 DP - 2021 Dec 1 TI - Development of a new risk stratification system for patients with newly diagnosed multiple myeloma using R-ISS and (18)F-FDG PET/CT. PG - 190 LID - 10.1038/s41408-021-00577-2 [doi] LID - 190 AB - In multiple myeloma (MM), a high number of focal lesions (FL) detected using positron emission tomography/computed tomography (PET/CT) was found to be associated with adverse prognosis. To design a new risk stratification system that combines the Revised International Staging System (R-ISS) with FL, we analyzed the data of 380 patients with newly diagnosed MM (NDMM) who underwent (18)F-fluorodeoxyglucose ((18)F-FDG) PET/CT upon diagnosis. The K-adaptive partitioning algorithm was adopted to define subgroups with homogeneous survival. The combined R-ISS with PET/CT classified NDMM patients into four groups: R-ISS/PET stage I (n = 31; R-ISS I with FL 3 and R-ISS II with FL 3 and R-ISS III with FL 3). The 2-year overall survival rates for stages I, II, III, and IV were 96.7%, 89.8%, 74.7%, and 50.3%. The 2-year progression-free survival rates were 84.1%, 64.7%, 40.8%, and 17.1%, respectively. The new R-ISS/PET was successfully validated in an external cohort. This new system had a remarkable prognostic power for estimating the survival outcomes of patients with NDMM. This system helps discriminate patients with a good prognosis from those with a poor prognosis more precisely. CI - (c) 2021. The Author(s). FAU - Cho, Hee Jeong AU - Cho HJ AUID- ORCID: 0000-0001-8300-8179 AD - Department of Hematology-Oncology, Kyungpook National University Hospital, School of Medicine, Kyungpook National University, Daegu, South Korea. FAU - Jung, Sung-Hoon AU - Jung SH AD - Department of Hematology-Oncology, Chonnam National University Hwasun Hospital and Chonnam National University Medical School, Hwasun-gun, Jeollanam-do, South Korea. FAU - Jo, Jae-Cheol AU - Jo JC AD - Department of Hematology and Oncology, Ulsan University Hospital, University of Ulsan College of Medicine, Ulsan, Korea. FAU - Lee, Yoo Jin AU - Lee YJ AD - Department of Hematology and Oncology, Ulsan University Hospital, University of Ulsan College of Medicine, Ulsan, Korea. FAU - Yoon, Sang Eun AU - Yoon SE AD - Department of Medicine, Sungkyunkwan University School of Medicine, Samsung Medical Center, Seoul, South Korea. FAU - Park, Sung-Soo AU - Park SS AUID- ORCID: 0000-0002-8826-4136 AD - Department of Hematology, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, South Korea. FAU - Kim, Do Young AU - Kim DY AUID- ORCID: 0000-0002-9468-8939 AD - Department of Hematology-Oncology, Pusan National University Hospital, Pusan National University School of Medicine, Busan, South Korea. FAU - Shin, Ho-Jin AU - Shin HJ AD - Department of Hematology-Oncology, Pusan National University Hospital, Pusan National University School of Medicine, Busan, South Korea. FAU - Mun, Yeung-Chul AU - Mun YC AUID- ORCID: 0000-0002-1882-3983 AD - Department of Hematology-Oncology, Ewha Womans University Medical Center, Seoul, South Korea. FAU - Yi, Jun Ho AU - Yi JH AD - Department of Hematology-Oncology, Chung-Ang University Hospital, Seoul, South Korea. FAU - Kim, Hyo Jung AU - Kim HJ AD - Department of Hematology-Oncology, Hallym University Sacred Heart Hospital, Anyang, South Korea. FAU - Kim, Da Jung AU - Kim DJ AD - Department of Hematology-Oncology, Kosin University Gosper Hospital, Busan, South Korea. FAU - Lee, Ho Sup AU - Lee HS AD - Department of Hematology-Oncology, Kosin University Gosper Hospital, Busan, South Korea. FAU - Bae, Sung Hwa AU - Bae SH AD - Department of Hematology-Oncology, Daegu Catholic University Hospital, Daegu Catholic University School of Medicine, Daegu, South Korea. FAU - Hong, Chae Moon AU - Hong CM AD - Department of Nuclear Medicine, Kyungpook National University Hospital, School of Medicine, Kyungpook National University, Daegu, South Korea. FAU - Jeong, Shin Young AU - Jeong SY AD - Department of Nuclear Medicine, Kyungpook National University Hospital, School of Medicine, Kyungpook National University, Daegu, South Korea. FAU - Min, Jung-Joon AU - Min JJ AD - Department of Nuclear Medicine, Chonnam National University Hwasun Hospital and Chonnam National University Medical School, Hwasun-gun, Jeollanam-do, South Korea. FAU - Sohn, Sang Kyun AU - Sohn SK AD - Department of Hematology-Oncology, Kyungpook National University Hospital, School of Medicine, Kyungpook National University, Daegu, South Korea. FAU - Min, Chang-Ki AU - Min CK AD - Department of Hematology, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, South Korea. FAU - Kim, Kihyun AU - Kim K AUID- ORCID: 0000-0002-5878-8895 AD - Department of Medicine, Sungkyunkwan University School of Medicine, Samsung Medical Center, Seoul, South Korea. FAU - Lee, Je-Jung AU - Lee JJ AUID- ORCID: 0000-0002-4635-5697 AD - Department of Hematology-Oncology, Chonnam National University Hwasun Hospital and Chonnam National University Medical School, Hwasun-gun, Jeollanam-do, South Korea. drjejung@chonnam.ac.kr. FAU - Moon, Joon Ho AU - Moon JH AUID- ORCID: 0000-0003-3756-796X AD - Department of Hematology-Oncology, Kyungpook National University Hospital, School of Medicine, Kyungpook National University, Daegu, South Korea. jhmoon@knu.ac.kr. CN - Korean Multiple Myeloma Working Party LA - eng PT - Journal Article DEP - 20211201 PL - United States TA - Blood Cancer J JT - Blood cancer journal JID - 101568469 RN - 0Z5B2CJX4D (Fluorodeoxyglucose F18) SB - IM MH - Adult MH - Aged MH - Aged, 80 and over MH - Female MH - Fluorodeoxyglucose F18/analysis MH - Humans MH - Male MH - Middle Aged MH - Multiple Myeloma/*diagnosis/etiology MH - Neoplasm Staging MH - Positron Emission Tomography Computed Tomography MH - Prognosis MH - Risk Assessment PMC - PMC8636569 COIS- The authors declare no competing interests. FIR - Cho, Hee Jeong IR - Cho HJ FIR - Jung, Sung-Hoon IR - Jung SH FIR - Jo, Jae-Cheol IR - Jo JC FIR - Lee, Yoo Jin IR - Lee YJ FIR - Yoon, Sang Eun IR - Yoon SE FIR - Park, Sung-Soo IR - Park SS FIR - Kim, Do Young IR - Kim DY FIR - Shin, Ho-Jin IR - Shin HJ FIR - Mun, Yeung-Chul IR - Mun YC FIR - Yi, Jun Ho IR - Yi JH FIR - Kim, Hyo Jung IR - Kim HJ FIR - Kim, Da Jung IR - Kim DJ FIR - Lee, Ho Sup IR - Lee HS FIR - Bae, Sung Hwa IR - Bae SH FIR - Hong, Chae Moon IR - Hong CM FIR - Jeong, Shin Young IR - Jeong SY FIR - Min, Jung-Joon IR - Min JJ FIR - Sohn, Sang Kyun IR - Sohn SK FIR - Min, Chang-Ki IR - Min CK FIR - Kim, Kihyun IR - Kim K FIR - Lee, Je-Jung IR - Lee JJ FIR - Moon, Joon Ho IR - Moon JH EDAT- 2021/12/03 06:00 MHDA- 2022/02/03 06:00 PMCR- 2021/12/01 CRDT- 2021/12/02 05:57 PHST- 2021/07/16 00:00 [received] PHST- 2021/11/03 00:00 [accepted] PHST- 2021/10/28 00:00 [revised] PHST- 2021/12/02 05:57 [entrez] PHST- 2021/12/03 06:00 [pubmed] PHST- 2022/02/03 06:00 [medline] PHST- 2021/12/01 00:00 [pmc-release] AID - 10.1038/s41408-021-00577-2 [pii] AID - 577 [pii] AID - 10.1038/s41408-021-00577-2 [doi] PST - epublish SO - Blood Cancer J. 2021 Dec 1;11(12):190. doi: 10.1038/s41408-021-00577-2.