PMID- 34853704
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20211203
IS  - 2090-004X (Print)
IS  - 2090-0058 (Electronic)
IS  - 2090-004X (Linking)
VI  - 2021
DP  - 2021
TI  - The Determination of Type 2 Diabetes Mellitus's Impact on the Density of Retinal 
      Blood Vessels and the Choriocapillaris: Optical Coherence Tomography Angiography 
      Study.
PG  - 7043251
LID - 10.1155/2021/7043251 [doi]
LID - 7043251
AB  - Optical coherence tomography angiography (OCTA) was used to analyze the 
      alterations in the density of retinal blood vessels and the choriocapillaris (VD) 
      in patients suffering from type 2 diabetes mellitus (T2DM). One hundred sixty-six 
      eyes of 83 patients (43 of whom were men and 40 women, with a mean age of 
      58.59 +/- 14.04) with T2DM and without diabetic retinopathy were examined for the 
      purpose of conducting the observational prospective study. The control group (CG) 
      consisted of 66 eyes in 33 healthy subjects (15 male and 18 female, with a mean 
      age of 55.12 +/- 12.70). The measurement regions of vessel density (VD) included 
      the deep capillary plexus (DCP), the superficial capillary plexus (SCP), and the 
      choriocapillaris. The results indicate considerable differences in the VD of the 
      DCP and SCP when comparing the control group with the study groups (p < 0.001). 
      In comparison with the control group (p < 0.001), there was a statistically 
      significant reduction in the VD of the choriocapillaris in the study group. 
      Furthermore, patients with T2DM showed a significantly decreased VD concerning 
      the control in different macular regions. Thickness in several macular regions in 
      the study group significantly decreased compared to the ones in the control 
      group. OCTA was used to gather relevant information about the vascular changes 
      which occurred in T2DM patients, assessed through the quantitative analysis of 
      the blood flow in the retina and choriocapillaris.
CI  - Copyright (c) 2021 Marko Zlatanovic et al.
FAU - Zlatanovic, Marko
AU  - Zlatanovic M
AD  - Clinical Center Nis, Ophthalmology Clinic, Nis, Serbia.
FAU - Dordevic Jocic, Jasmina
AU  - Dordevic Jocic J
AD  - Clinical Center Nis, Ophthalmology Clinic, Nis, Serbia.
AD  - University of Nis, Faculty of Medicine, Department of Ophthalmology, Nis, Serbia.
FAU - Jaksic, Vesna
AU  - Jaksic V
AD  - University of Belgrade, Medical Faculty, Department of Ophthalmology, Belgrade, 
      Serbia.
FAU - Zlatanovic, Nevena
AU  - Zlatanovic N
AD  - Community Health Center Nis in Nis, Nis, Serbia.
FAU - Golubovic, Mladan
AU  - Golubovic M
AD  - University of Nis, Medical Faculty, Clinic for Anesthesiology and Intensive Care 
      at the Clinical Center Nis in Nis, Nis, Serbia.
FAU - Zivkovic, Maja
AU  - Zivkovic M
AUID- ORCID: 0000-0002-4145-5242
AD  - Clinical Center Nis, Ophthalmology Clinic, Nis, Serbia.
AD  - University of Nis, Faculty of Medicine, Department of Ophthalmology, Nis, Serbia.
LA  - eng
PT  - Journal Article
DEP - 20211122
PL  - United States
TA  - J Ophthalmol
JT  - Journal of ophthalmology
JID - 101524199
PMC - PMC8629665
COIS- The authors declare that they have no conflicts of interest.
EDAT- 2021/12/03 06:00
MHDA- 2021/12/03 06:01
PMCR- 2021/11/22
CRDT- 2021/12/02 06:37
PHST- 2021/08/26 00:00 [received]
PHST- 2021/11/10 00:00 [accepted]
PHST- 2021/12/02 06:37 [entrez]
PHST- 2021/12/03 06:00 [pubmed]
PHST- 2021/12/03 06:01 [medline]
PHST- 2021/11/22 00:00 [pmc-release]
AID - 10.1155/2021/7043251 [doi]
PST - epublish
SO  - J Ophthalmol. 2021 Nov 22;2021:7043251. doi: 10.1155/2021/7043251. eCollection 
      2021.