PMID- 34854343
OWN - NLM
STAT- MEDLINE
DCOM- 20220303
LR  - 20220303
IS  - 1748-6963 (Electronic)
IS  - 1743-5889 (Linking)
VI  - 16
IP  - 29
DP  - 2021 Dec
TI  - HA/PEI-coated acridine orange-loaded gold-core silica shell nanorods for 
      cancer-targeted photothermal and chemotherapy.
PG  - 2569-2586
LID - 10.2217/nnm-2021-0270 [doi]
AB  - Aims: To develop a tumor-targeted chemo-photothermal nanomedicine through the 
      functionalization of acridine orange (AO)-loaded gold-core mesoporous silica 
      shell (AuMSS) nanorods with polyethylenimine (PEI) and hyaluronic acid (HA). 
      Methods: Functionalization of the AuMSS nanorods was achieved through the 
      chemical linkage of PEI followed by electrostatic adsorption of HA. Results: HA 
      functionalization improved AuMSS' cytocompatibility by decreasing blood 
      hemolysis, and PEI-HA inclusion promoted a controlled and sustained AO release. 
      In vitro assays revealed that HA functionalization increased the internalization 
      of nanoparticles by human negroid cervix epithelioid carcinoma cancer 
      (HeLa) cells, and the combinatorial treatment mediated by AuMSS/PEI/HA_AO 
      nanorods presented an enhanced effect, with >95% of cellular death. Conclusion: 
      AuMSS/PEI/HA_AO formulations can act as tumor-targeted chemo-photothermal 
      nanomedicines for the combinatorial therapy of cervical cancer.
FAU - F Rodrigues, Carolina
AU  - F Rodrigues C
AUID- ORCID: 0000-0002-5493-8331
AD  - CICS-UBI - Health Sciences Research Centre, Universidade da Beira Interior, Av. 
      Infante D. Henrique, 6200-506, Covilha, Portugal.
FAU - Fernandes, Natanael
AU  - Fernandes N
AUID- ORCID: 0000-0002-7737-9288
AD  - CICS-UBI - Health Sciences Research Centre, Universidade da Beira Interior, Av. 
      Infante D. Henrique, 6200-506, Covilha, Portugal.
FAU - de Melo-Diogo, Duarte
AU  - de Melo-Diogo D
AUID- ORCID: 0000-0001-9984-3603
AD  - CICS-UBI - Health Sciences Research Centre, Universidade da Beira Interior, Av. 
      Infante D. Henrique, 6200-506, Covilha, Portugal.
FAU - Ferreira, Paula
AU  - Ferreira P
AUID- ORCID: 0000-0003-3393-4427
AD  - CIEPQPF - Departamento de Engenharia Quimica, Universidade de Coimbra, Rua Silvio 
      Lima, 3030-790, Coimbra, Portugal.
FAU - J Correia, Ilidio
AU  - J Correia I
AUID- ORCID: 0000-0003-1613-9675
AD  - CICS-UBI - Health Sciences Research Centre, Universidade da Beira Interior, Av. 
      Infante D. Henrique, 6200-506, Covilha, Portugal.
AD  - CIEPQPF - Departamento de Engenharia Quimica, Universidade de Coimbra, Rua Silvio 
      Lima, 3030-790, Coimbra, Portugal.
FAU - F Moreira, Andre
AU  - F Moreira A
AUID- ORCID: 0000-0002-0604-2506
AD  - CICS-UBI - Health Sciences Research Centre, Universidade da Beira Interior, Av. 
      Infante D. Henrique, 6200-506, Covilha, Portugal.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20211202
PL  - England
TA  - Nanomedicine (Lond)
JT  - Nanomedicine (London, England)
JID - 101278111
RN  - 7440-57-5 (Gold)
RN  - 7631-86-9 (Silicon Dioxide)
RN  - 80168379AG (Doxorubicin)
RN  - 9002-98-6 (Polyethyleneimine)
RN  - 9004-61-9 (Hyaluronic Acid)
RN  - F30N4O6XVV (Acridine Orange)
SB  - IM
MH  - Acridine Orange
MH  - Doxorubicin
MH  - Gold
MH  - Humans
MH  - Hyaluronic Acid
MH  - *Nanoparticles
MH  - *Nanotubes
MH  - *Neoplasms/drug therapy
MH  - Polyethyleneimine
MH  - Silicon Dioxide
OTO - NOTNLM
OT  - acridine orange
OT  - cancer
OT  - gold-core silica shell nanoparticles
OT  - hyaluronic acid
OT  - photothermal therapy
OT  - polyethylenimine
EDAT- 2021/12/03 06:00
MHDA- 2022/03/04 06:00
CRDT- 2021/12/02 08:42
PHST- 2021/12/03 06:00 [pubmed]
PHST- 2022/03/04 06:00 [medline]
PHST- 2021/12/02 08:42 [entrez]
AID - 10.2217/nnm-2021-0270 [doi]
PST - ppublish
SO  - Nanomedicine (Lond). 2021 Dec;16(29):2569-2586. doi: 10.2217/nnm-2021-0270. Epub 
      2021 Dec 2.