PMID- 34854784
OWN - NLM
STAT- MEDLINE
DCOM- 20220812
LR  - 20220812
IS  - 1724-6016 (Electronic)
IS  - 1120-6721 (Linking)
VI  - 32
IP  - 5
DP  - 2022 Sep
TI  - Risk factors in central retinal vein occlusion: A multi-center case-control study 
      conducted on the Italian population : Demographic, environmental, systemic, and 
      ocular factors that increase the risk for major thrombotic events in the retinal 
      venous system.
PG  - 2801-2809
LID - 10.1177/11206721211064469 [doi]
AB  - PURPOSE: To explore the risk factors for central retinal vein occlusion (CRVO) by 
      comparing a large sample of patients with healthy controls. MATERIALS AND 
      METHODS: Multi-center case-control study. The study group includes patients 
      affected by central retinal vein occlusion, confirmed angiographically, aged 50 
      years old or above (Group A). The control group includes healthy subjects without 
      an history of retinal vein occlusion (Group B). Outcome measures: age, gender, 
      active smoking, presence of uncontrolled arterial hypertension (uHTN), presence 
      of the following comorbidities: diabetes mellitus type II (DMII), chronic liver 
      disease (CLD), chronic kidney disease (CKD), thyroid disease (TD), systemic lupus 
      erythematosus (SLE), hyperhomocystenemia (HHcy), dyslipidemia (DLip), carotid 
      artery disease (CAD), glaucoma, atrial fibrillation (AF), migraine headache (MH), 
      chronic obstructive pulmonary disease (COPD), obstructive sleep apnea syndrome 
      (OSAS), history of myocardial infarction (MI). Odds-ratios were calculated with 
      logistic regression analysis. RESULTS: A total of 203 patients (Group A) and 339 
      controls (Group B). Statistically-significant differences were found for the 
      following variables: age (OR: 1.109 [1.081-1.138], p < .001), active smoking (OR: 
      2.048 [1.210- 3.466], p < .008), DMII (OR: 4.533 [2.097-9.803], p < .001), HHcy 
      (OR: 4.507 [2.477-10.001 ], p < .001), DLip (OR: 2.255 [1.352-3.762], 
      p  =  .002), CAD (OR: 6.632 [2.944- 14.942], p < .001), glaucoma (OR: 4.656 
      [2.031-10.673], < .001), OSAS (OR: 1.744 [1.023-2.975], < .041), uHTN (OR: 3.656 
      [2.247-5.949], < .001). No statistically-significant differences were found for 
      the other variables. CONCLUSIONS: Older age, active smoking, as well as presence 
      of DMII, HHcy, DLip, CAD, glaucoma, OSAS, and uHTN, all increase the risk for 
      CRVO. A comprehensive assessment of patients with CRVO is paramount. Adequate 
      control of all the aforementioned risk factors is likely of great significance in 
      reducing the incidence of CRVO among the general population, and it likely plays 
      an important role in improving the prognosis following the occlusive event.
FAU - Trovato Battagliola, Edoardo
AU  - Trovato Battagliola E
AD  - Department of Sense Organs, La Sapienza University of Rome, Rome, Italy.
FAU - Pacella, Fernanda
AU  - Pacella F
AD  - Department of Sense Organs, La Sapienza University of Rome, Rome, Italy.
FAU - Malvasi, Mariaelena
AU  - Malvasi M
AD  - Department of Sense Organs, La Sapienza University of Rome, Rome, Italy.
FAU - Scalinci, Sergio Zaccaria
AU  - Scalinci SZ
AD  - DIMEC (Department of Medical and Surgical Sciences), 9296University of Bologna, 
      Bologna, Italy.
FAU - Turchetti, Paolo
AU  - Turchetti P
AD  - National Institute for Health, Migration and Poverty (INMP/NIHMP), Rome, Italy.
FAU - Pacella, Elena
AU  - Pacella E
AUID- ORCID: 0000-0002-5431-6399
AD  - Department of Sense Organs, La Sapienza University of Rome, Rome, Italy.
FAU - La Torre, Giuseppe
AU  - La Torre G
AD  - Department of Public Health and Infectious Diseases, 9311Sapienza University of 
      Rome, Rome, Italy.
FAU - Arrico, Loredana
AU  - Arrico L
AD  - Department of Sense Organs, La Sapienza University of Rome, Rome, Italy.
LA  - eng
PT  - Journal Article
PT  - Multicenter Study
DEP - 20211202
PL  - United States
TA  - Eur J Ophthalmol
JT  - European journal of ophthalmology
JID - 9110772
SB  - IM
MH  - Case-Control Studies
MH  - *Glaucoma
MH  - Humans
MH  - Incidence
MH  - Middle Aged
MH  - *Retinal Vein Occlusion/diagnosis/epidemiology/etiology
MH  - Risk Factors
MH  - *Sleep Apnea, Obstructive
OTO - NOTNLM
OT  - BRVO
OT  - CRVO
OT  - RVO
OT  - Retinal vein occlusion
OT  - branch
OT  - central
OT  - ocular
OT  - risk factors
OT  - systemic
EDAT- 2021/12/03 06:00
MHDA- 2022/08/13 06:00
CRDT- 2021/12/02 12:15
PHST- 2021/12/03 06:00 [pubmed]
PHST- 2022/08/13 06:00 [medline]
PHST- 2021/12/02 12:15 [entrez]
AID - 10.1177/11206721211064469 [doi]
PST - ppublish
SO  - Eur J Ophthalmol. 2022 Sep;32(5):2801-2809. doi: 10.1177/11206721211064469. Epub 
      2021 Dec 2.