PMID- 34856028
OWN - NLM
STAT- MEDLINE
DCOM- 20220317
LR  - 20220317
IS  - 1399-3038 (Electronic)
IS  - 0905-6157 (Linking)
VI  - 33
IP  - 1
DP  - 2022 Jan
TI  - Investigating obesity-related risk factors for childhood asthma.
PG  - e13710
LID - 10.1111/pai.13710 [doi]
AB  - BACKGROUND: We tested the hypothesis that multiple obesity-related risk factors 
      (obesity, physical activity, cardiopulmonary physical fitness, sleep-disorder 
      breathing (SDB), and sleep quality) are associated with childhood asthma using a 
      Mendelian randomization (MR) design. Furthermore, we aim to investigate whether 
      these risk factors were associated with incident asthma prospectively. METHODS: 
      In total, 7069 children aged 12 from the Taiwan Children Health Study were 
      enrolled in the current study. Cross-sectional logistic regression, one-sample 
      MR, summary-level MR sensitivity analyses, and prospective survival analyses were 
      used to investigate each causal pathway. RESULTS: In MR analysis, three of the 
      five risk factors (obesity, SDB, and sleep quality) were associated with asthma, 
      with the highest effect sizes per inter-quartile range (IQR) increase observed 
      for sleep quality (odds ratio [OR] = 1.42; 95% confidence interval [CI]: 1.06 to 
      1.92) and the lowest for obesity (OR = 1.08; 95% CI: 1.00-1.16). In the 
      prospective survival analysis, obesity showed the highest risk of incident asthma 
      per IQR increase (hazard ratio [HR] = 1.28; 95% CI: 1.05 to 1.56), followed by 
      SDB (HR = 1.18; 95% CI: 1.08 to 1.29) and sleep quality (HR = 1.10; 95% CI: 1.03 
      to 1.17). CONCLUSION: Among the examined factors, the most plausible risk factors 
      for asthma were obesity, SDB, and poor sleep quality. For the prevention of 
      childhood asthma, relevant stakeholders should prioritize improving children's 
      sleep quality and preventing obesity comorbidities such as SDB.
CI  - (c) 2021 EAACI and John Wiley and Sons A/S. Published by John Wiley and Sons Ltd.
FAU - Chen, Yang-Ching
AU  - Chen YC
AUID- ORCID: 0000-0002-0682-3716
AD  - Department of Family Medicine, Taipei Medical University Hospital, Taipei Medical 
      University, Taipei, Taiwan.
AD  - Department of Family Medicine, School of Medicine, College of Medicine, Taipei 
      Medical University, Taipei, Taiwan.
AD  - School of Nutrition and Health Sciences, College of Nutrition, Taipei Medical 
      University, Taipei, Taiwan.
AD  - Graduate Institute of Metabolism and Obesity Sciences, Taipei Medical University, 
      Taipei, Taiwan.
FAU - Su, Ming-Wei
AU  - Su MW
AUID- ORCID: 0000-0003-1198-7333
AD  - Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan.
FAU - Brumpton, Ben M
AU  - Brumpton BM
AUID- ORCID: 0000-0002-3058-1059
AD  - Clinic for Thoracic and Occupational Medicine, St. Olavs Hospital, Trondheim, 
      Norway.
AD  - MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK.
AD  - K.G. Jebsen Center for Genetic Epidemiology, Norwegian University of Science and 
      Technology, Trondheim, Norway.
FAU - Lee, Yungling L
AU  - Lee YL
AUID- ORCID: 0000-0002-2234-9479
AD  - Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan.
AD  - College of Public Health, China Medical University, Taichung, Taiwan.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20211214
PL  - England
TA  - Pediatr Allergy Immunol
JT  - Pediatric allergy and immunology : official publication of the European Society 
      of Pediatric Allergy and Immunology
JID - 9106718
SB  - IM
MH  - *Asthma/complications/epidemiology
MH  - Child
MH  - Cross-Sectional Studies
MH  - Humans
MH  - *Obesity/epidemiology
MH  - Prospective Studies
MH  - Risk Factors
OTO - NOTNLM
OT  - Mendelian Randomization Study
OT  - asthma
OT  - obesity
OT  - prospective study
OT  - pulmonary function
EDAT- 2021/12/03 06:00
MHDA- 2022/03/18 06:00
CRDT- 2021/12/02 17:41
PHST- 2021/11/27 00:00 [revised]
PHST- 2021/08/25 00:00 [received]
PHST- 2021/11/30 00:00 [accepted]
PHST- 2021/12/03 06:00 [pubmed]
PHST- 2022/03/18 06:00 [medline]
PHST- 2021/12/02 17:41 [entrez]
AID - 10.1111/pai.13710 [doi]
PST - ppublish
SO  - Pediatr Allergy Immunol. 2022 Jan;33(1):e13710. doi: 10.1111/pai.13710. Epub 2021 
      Dec 14.