PMID- 34856968 OWN - NLM STAT- MEDLINE DCOM- 20220124 LR - 20231108 IS - 1471-244X (Electronic) IS - 1471-244X (Linking) VI - 21 IP - 1 DP - 2021 Dec 2 TI - Short-term functional outcome in psychotic patients: results of the Turku early psychosis study (TEPS). PG - 602 LID - 10.1186/s12888-021-03516-4 [doi] LID - 602 AB - BACKGROUND: Functional recovery of patients with clinical and subclinical psychosis is associated with clinical, neuropsychological and developmental factors. Less is known about how these factors predict functional outcomes in the same models. We investigated functional outcomes and their predictors in patients with first-episode psychosis (FEP) or a confirmed or nonconfirmed clinical high risk of psychosis (CHR-P vs. CHR-N). METHODS: Altogether, 130 patients with FEP, 60 patients with CHR-P and 47 patients with CHR-N were recruited and extensively examined at baseline (T0) and 9 (T1) and 18 (T2) months later. Global Assessment of Functioning (GAF) at T0, T1 and T2 and psychotic, depression, and anxiety symptoms at T1 and T2 were assessed. Functional outcomes were predicted using multivariate repeated ANOVA. RESULTS: During follow-up, the GAF score improved significantly in patients with FEP and CHR-P but not in patients with CHR-N. A single marital status, low basic education level, poor work situation, disorganization symptoms, perceptual deficits, and poor premorbid adjustment in patients with FEP, disorganization symptoms and poor premorbid adjustment in patients with CHR-P, and a low basic education level, poor work situation and general symptoms in patients with CHR-N predicted poor functional outcomes. Psychotic symptoms at T1 in patients with FEP and psychotic and depression symptoms at T1 and anxiety symptoms at T2 in patients with CHR-P were associated with poor functioning. CONCLUSIONS: In patients with FEP and CHR-P, poor premorbid adjustment and disorganization symptomatology are common predictors of the functional outcome, while a low education level and poor work situation predict worse functional outcomes in patients with FEP and CHR-N. Interventions aimed at improving the ability to work and study are most important in improving the functioning of patients with clinical or subclinical psychosis. CI - (c) 2021. The Author(s). FAU - Salokangas, Raimo K R AU - Salokangas RKR AD - Department of Psychiatry, University of Turku, Kunnallissairaalantie 20, FIN-20700, Turku, Finland. Raimo.K.R.Salokangas@utu.fi. FAU - From, Tiina AU - From T AD - Department of Psychiatry, University of Turku, Kunnallissairaalantie 20, FIN-20700, Turku, Finland. FAU - Ilonen, Tuula AU - Ilonen T AD - Department of Psychiatry, University of Turku, Kunnallissairaalantie 20, FIN-20700, Turku, Finland. FAU - Luutonen, Sinikka AU - Luutonen S AD - Department of Psychiatry, University of Turku, Kunnallissairaalantie 20, FIN-20700, Turku, Finland. AD - Department of Psychiatry, Turku University Hospital, Turku, Finland. FAU - Heinimaa, Markus AU - Heinimaa M AD - Department of Psychiatry, University of Turku, Kunnallissairaalantie 20, FIN-20700, Turku, Finland. FAU - Armio, Reetta-Liina AU - Armio RL AD - Department of Psychiatry, University of Turku, Kunnallissairaalantie 20, FIN-20700, Turku, Finland. FAU - Laurikainen, Heikki AU - Laurikainen H AD - Department of Psychiatry, University of Turku, Kunnallissairaalantie 20, FIN-20700, Turku, Finland. FAU - Walta, Maija AU - Walta M AD - Department of Psychiatry, University of Turku, Kunnallissairaalantie 20, FIN-20700, Turku, Finland. FAU - Paju, Janina AU - Paju J AD - Department of Psychiatry, University of Turku, Kunnallissairaalantie 20, FIN-20700, Turku, Finland. FAU - Toivonen, Anna AU - Toivonen A AD - Department of Psychiatry, University of Turku, Kunnallissairaalantie 20, FIN-20700, Turku, Finland. FAU - Jalo, Paivi AU - Jalo P AD - Department of Psychiatry, Turku University Hospital, Turku, Finland. FAU - Tuominen, Lauri AU - Tuominen L AD - Department of Psychiatry, University of Turku, Kunnallissairaalantie 20, FIN-20700, Turku, Finland. AD - Royal Ottawa Mental Health Centre, Ottawa, Canada. FAU - Hietala, Jarmo AU - Hietala J AD - Department of Psychiatry, University of Turku, Kunnallissairaalantie 20, FIN-20700, Turku, Finland. AD - Department of Psychiatry, Turku University Hospital, Turku, Finland. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20211202 PL - England TA - BMC Psychiatry JT - BMC psychiatry JID - 100968559 SB - IM MH - Anxiety MH - Humans MH - *Psychotic Disorders/diagnosis PMC - PMC8641211 OTO - NOTNLM OT - Clinical high risk of psychosis OT - Disorganization symptoms OT - Functional outcome OT - Negative symptoms OT - Premorbid adjustment OT - Psychotic disorders COIS- The authors have no competing interests to declare. EDAT- 2021/12/04 06:00 MHDA- 2022/01/27 06:00 PMCR- 2021/12/02 CRDT- 2021/12/03 05:40 PHST- 2021/04/14 00:00 [received] PHST- 2021/09/28 00:00 [accepted] PHST- 2021/12/03 05:40 [entrez] PHST- 2021/12/04 06:00 [pubmed] PHST- 2022/01/27 06:00 [medline] PHST- 2021/12/02 00:00 [pmc-release] AID - 10.1186/s12888-021-03516-4 [pii] AID - 3516 [pii] AID - 10.1186/s12888-021-03516-4 [doi] PST - epublish SO - BMC Psychiatry. 2021 Dec 2;21(1):602. doi: 10.1186/s12888-021-03516-4.