PMID- 34857224
OWN - NLM
STAT- MEDLINE
DCOM- 20220202
LR  - 20220202
IS  - 2405-4577 (Electronic)
IS  - 2405-4577 (Linking)
VI  - 46
DP  - 2021 Dec
TI  - Sarcopenia with co-existent type 2 diabetes mellitus is associated with worse 
      clinical outcomes among hospitalised cardiac patients.
PG  - 380-385
LID - S2405-4577(21)01056-1 [pii]
LID - 10.1016/j.clnesp.2021.08.039 [doi]
AB  - BACKGROUND & AIMS: Sarcopenia has been shown associated with functional decline, 
      disability, poorer quality of life and mortality. However, there are limited 
      studies among hospitalised cardiac patients in Malaysia. This study aimed to 
      identify the association of sarcopenia and type 2 diabetes mellitus (T2DM) with 
      clinical outcomes among hospitalised cardiac patients. METHODS: This prospective 
      observational study assessed 100 patients who were admitted to the general wards 
      at the National Heart Institute. We measured handgrip strength, body composition 
      using bioelectrical impedance analysis (BIA) and recorded the length of stay 
      (LOS), unplanned readmission and incidence of infection within 90 days after 
      discharge. Logistic regression analysis at a significant level p < 0.05 was used 
      to identify the association between sarcopenia and clinical outcomes. RESULTS: 
      The prevalence of sarcopenia was 63%, and this was similar in patients with or 
      without T2DM. After adjustment, sarcopenia was significantly associated with 
      90-day unplanned readmission (adjusted OR 3.5; 95%CI 1.40-8.77; p = 0.007) and 
      LOS (AOR 0.4; 95%CI 0.16-0.88; p = 0.026). After adjustment, the co-existent of 
      T2DM and sarcopenia was significantly associated with 90-day unplanned 
      readmission (AOR 7.3; 95%CI 1.82-29.66; p = 0.005) and 90-day incidence of 
      infection (AOR 4.4; 95%CI 1.12-17.52; p = 0.033). CONCLUSION: Sarcopenia with 
      co-existent T2DM was associated with increased risk for readmission and infection 
      among hospitalised cardiac patients. Early identification of sarcopenia is 
      important for timely intervention to improve prognosis in hospitalised cardiac 
      patients with T2DM.
CI  - Copyright (c) 2021 European Society for Clinical Nutrition and Metabolism. 
      Published by Elsevier Ltd. All rights reserved.
FAU - Sundar, Vatana V
AU  - Sundar VV
AD  - Department of Nutrition and Dietetics, School of Health Sciences, International 
      Medical University, No.126, Jalan Jalil Perkasa 19, Bukit Jalil, 57000, Kuala 
      Lumpur, Malaysia; Dietetics and Food Services, National Heart Institute, 145, 
      Jalan Tun Razak, 50400, Kuala Lumpur, Malaysia. Electronic address: 
      vatana@ijn.com.my.
FAU - Ong, Shu Hwa
AU  - Ong SH
AD  - Department of Nutrition and Dietetics, School of Health Sciences, International 
      Medical University, No.126, Jalan Jalil Perkasa 19, Bukit Jalil, 57000, Kuala 
      Lumpur, Malaysia. Electronic address: ongshuhwa@imu.edu.my.
FAU - Easaw, Mary Easaw P M
AU  - Easaw MEPM
AD  - Department of Nutrition and Dietetics, School of Health Sciences, International 
      Medical University, No.126, Jalan Jalil Perkasa 19, Bukit Jalil, 57000, Kuala 
      Lumpur, Malaysia. Electronic address: maryeasaw@imu.edu.my.
FAU - Chee, Winnie Siew Swee
AU  - Chee WSS
AD  - Department of Nutrition and Dietetics, School of Health Sciences, International 
      Medical University, No.126, Jalan Jalil Perkasa 19, Bukit Jalil, 57000, Kuala 
      Lumpur, Malaysia. Electronic address: winnie_chee@imu.edu.my.
LA  - eng
PT  - Journal Article
PT  - Observational Study
PT  - Research Support, Non-U.S. Gov't
DEP - 20210929
PL  - England
TA  - Clin Nutr ESPEN
JT  - Clinical nutrition ESPEN
JID - 101654592
SB  - IM
MH  - *Diabetes Mellitus, Type 2/complications/epidemiology
MH  - Hand Strength
MH  - Humans
MH  - Patient Readmission
MH  - Quality of Life
MH  - *Sarcopenia/diagnosis/epidemiology
OTO - NOTNLM
OT  - Cardiac
OT  - Clinical outcomes
OT  - Hospitalised
OT  - Sarcopenia
OT  - Type 2 diabetes mellitus
COIS- Declaration of competing interest The authors declare that they have no conflict 
      of interest.
EDAT- 2021/12/04 06:00
MHDA- 2022/02/03 06:00
CRDT- 2021/12/03 05:49
PHST- 2021/05/08 00:00 [received]
PHST- 2021/08/11 00:00 [revised]
PHST- 2021/08/30 00:00 [accepted]
PHST- 2021/12/03 05:49 [entrez]
PHST- 2021/12/04 06:00 [pubmed]
PHST- 2022/02/03 06:00 [medline]
AID - S2405-4577(21)01056-1 [pii]
AID - 10.1016/j.clnesp.2021.08.039 [doi]
PST - ppublish
SO  - Clin Nutr ESPEN. 2021 Dec;46:380-385. doi: 10.1016/j.clnesp.2021.08.039. Epub 
      2021 Sep 29.