PMID- 34858347
OWN - NLM
STAT- MEDLINE
DCOM- 20220215
LR  - 20220215
IS  - 1664-2392 (Print)
IS  - 1664-2392 (Electronic)
IS  - 1664-2392 (Linking)
VI  - 12
DP  - 2021
TI  - Life-Time Environmental Chemical Exposure and Obesity: Review of Epidemiological 
      Studies Using Human Biomonitoring Methods.
PG  - 778737
LID - 10.3389/fendo.2021.778737 [doi]
LID - 778737
AB  - The exponential global increase in the incidence of obesity may be partly 
      attributable to environmental chemical (EC) exposure. Humans are constantly 
      exposed to ECs, primarily through environmental components. This review compiled 
      human epidemiological study findings of associations between blood and/or urinary 
      exposure levels of ECs and anthropometric overweight and obesity indices. The 
      findings reveal research gaps that should be addressed. We searched MEDLINE 
      (PubMed) for full text English articles published in 2006-2020 using the keywords 
      "environmental exposure" and "obesity". A total of 821 articles were retrieved; 
      102 reported relationships between environmental exposure and obesity indices. 
      ECs were the predominantly studied environmental exposure compounds. The ECs were 
      grouped into phenols, phthalates, and persistent organic pollutants (POPs) to 
      evaluate obesogenic roles. In total, 106 articles meeting the inclusion criteria 
      were summarized after an additional search by each group of EC combined with 
      obesity in the PubMed and Scopus databases. Dose-dependent positive associations 
      between bisphenol A (BPA) and various obesity indices were revealed. Both 
      individual and summed di(2-ethylhexyl) phthalate (DEHP) and non-DEHP metabolites 
      showed inconsistent associations with overweight and obesity indices, although 
      mono-butyl phthalate (MBP), mono-ethyl phthalate (MEP), and mono-benzyl phthalate 
      (MBzP) seem to have obesogenic roles in adolescents, adults, and the elderly. 
      Maternal exposure levels of individual POP metabolites or congeners showed 
      inconsistent associations, whereas dichlorodiphenyldichloroethylene (DDE) and 
      perfluorooctanoic acid (PFOA) were positively associated with obesity indices. 
      There was insufficient evidence of associations between early childhood EC 
      exposure and the subsequent development of overweight and obesity in late 
      childhood. Overall, human evidence explicitly reveals the consistent obesogenic 
      roles of BPA, DDE, and PFOA, but inconsistent roles of phthalate metabolites and 
      other POPs. Further prospective studies may yield deeper insights into the 
      overall scenario.
CI  - Copyright (c) 2021 Mohanto, Ito, Kato and Kamijima.
FAU - Mohanto, Nayan Chandra
AU  - Mohanto NC
AD  - Department of Occupational and Environmental Health, Nagoya City University 
      Graduate School of Medical Sciences, Nagoya, Japan.
FAU - Ito, Yuki
AU  - Ito Y
AD  - Department of Occupational and Environmental Health, Nagoya City University 
      Graduate School of Medical Sciences, Nagoya, Japan.
FAU - Kato, Sayaka
AU  - Kato S
AD  - Department of Occupational and Environmental Health, Nagoya City University 
      Graduate School of Medical Sciences, Nagoya, Japan.
FAU - Kamijima, Michihiro
AU  - Kamijima M
AD  - Department of Occupational and Environmental Health, Nagoya City University 
      Graduate School of Medical Sciences, Nagoya, Japan.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20211111
PL  - Switzerland
TA  - Front Endocrinol (Lausanne)
JT  - Frontiers in endocrinology
JID - 101555782
RN  - 0 (Environmental Pollutants)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Age Factors
MH  - Aged
MH  - Aging/drug effects/physiology
MH  - Child
MH  - Environmental Exposure/adverse effects/statistics & numerical data
MH  - Environmental Pollutants/*toxicity
MH  - Epidemiologic Studies
MH  - Female
MH  - Growth and Development/*drug effects
MH  - Humans
MH  - Male
MH  - Obesity/*epidemiology/etiology
MH  - Pregnancy
PMC - PMC8632231
OTO - NOTNLM
OT  - bisphenols
OT  - environmental chemicals
OT  - environmental obesogens
OT  - human biomonitoring
OT  - obesity
OT  - overweight
OT  - persistent organic pollutants
OT  - phthalates
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2021/12/04 06:00
MHDA- 2022/02/16 06:00
PMCR- 2021/01/01
CRDT- 2021/12/03 07:02
PHST- 2021/09/17 00:00 [received]
PHST- 2021/10/23 00:00 [accepted]
PHST- 2021/12/03 07:02 [entrez]
PHST- 2021/12/04 06:00 [pubmed]
PHST- 2022/02/16 06:00 [medline]
PHST- 2021/01/01 00:00 [pmc-release]
AID - 10.3389/fendo.2021.778737 [doi]
PST - epublish
SO  - Front Endocrinol (Lausanne). 2021 Nov 11;12:778737. doi: 
      10.3389/fendo.2021.778737. eCollection 2021.