PMID- 34859763 OWN - NLM STAT- MEDLINE DCOM- 20220908 LR - 20221020 IS - 2040-1752 (Electronic) IS - 2040-1744 (Linking) VI - 13 IP - 5 DP - 2022 Oct TI - Sex specific associations between in utero exposure to persistent organic pollutants and allergy-related outcomes in childhood: The Rhea Mother-Child Cohort (Crete, Greece). PG - 566-574 LID - 10.1017/S2040174421000660 [doi] AB - Accumulating evidence suggests that in utero exposures can influence the development of the immune system. Few studies have investigated whether prenatal exposure to persistent organic pollutants (POPs) is associated with allergy-related phenotypes in childhood, nor explored sex differences. We examined the association between prenatal exposure to POPs and offspring allergic outcomes in early and mid-childhood. We included 682 mother-child pairs from the prospective birth cohort Rhea. We measured dichlorodiphenyldichloroethylene (DDE), hexachlorobenzene (HCB) and 6 polychlorinated biphenyl (PCB) congeners in maternal first trimester serum. Parents completed the questionnaires adapted from the International Study on Asthma and Allergy in Childhood (ISAAC) for allergy-related phenotypes when their children were 4 and 6 years old. We used Poisson regression models to estimate Risk Ratios. Prenatal HCB was associated with increased risk for rhinoconjunctivitis at 6 years (RR (95% CI): 2.5; (1.3, 4.8) for a doubling in the exposure). Among girls, prenatal DDE was associated with increased risk for current wheeze, current asthma and current rhinoconjunctivitis at 4 years (RR (95%CI): 1.4 (0.8, 2.6), 1.6 (1.1, 2.4) and 1.8 (1.0, 3.3) and p-interaction = 0.035, 0.027 and 0.059, respectively), with increased risk for current rhinoconjunctivitis at 6 years (RR (95%CI): 1.7 (0.7, 3.8) and p-interaction = 0.028) and total PCBs were associated with increased risk for current eczema at 4 years (RR (95%CI): 2.1 (1.1, 4.2) and p-interaction = 0.028). In boys, prenatal DDE was associated with decreased risk for current wheeze and current asthma at 4 years. Our findings suggest that even low levels of exposure to POPs prenatally may affect the development of childhood allergy-related outcomes in a sex and age-specific manner. FAU - Margetaki, Katerina AU - Margetaki K AD - Department of Social Medicine, Faculty of Medicine, University of Crete, Heraklion, Greece. FAU - Alexaki, Maria AU - Alexaki M AD - Department of Social Medicine, Faculty of Medicine, University of Crete, Heraklion, Greece. FAU - Vittorakis, Evangelos AU - Vittorakis E AD - Department of Social Medicine, Faculty of Medicine, University of Crete, Heraklion, Greece. FAU - Roumeliotaki, Theano AU - Roumeliotaki T AD - Department of Social Medicine, Faculty of Medicine, University of Crete, Heraklion, Greece. FAU - Leventakou, Vasiliki AU - Leventakou V AD - Department of Social Medicine, Faculty of Medicine, University of Crete, Heraklion, Greece. AD - Department of Health Research Governance, Ministry of Public Health, AL Rumaila, Doha, Qatar. FAU - Bempi, Vicky AU - Bempi V AD - Department of Social Medicine, Faculty of Medicine, University of Crete, Heraklion, Greece. FAU - Chalkiadaki, Georgia AU - Chalkiadaki G AD - Department of Social Medicine, Faculty of Medicine, University of Crete, Heraklion, Greece. FAU - Kyrtopoulos, Soterios A AU - Kyrtopoulos SA AD - Institute of Biology, Institute of Chemical Biology, National Hellenic Research Foundation, Athens, Greece. FAU - Rantakokko, Panu AU - Rantakokko P AD - Department of Health Security, Finnish Institute for Health and Welfare, Kuopio, Finland. FAU - Kiviranta, Hannu AU - Kiviranta H AD - Department of Health Security, Finnish Institute for Health and Welfare, Kuopio, Finland. FAU - Stephanou, Euripides G AU - Stephanou EG AD - Environmental Chemical Processes Laboratory, Department of Chemistry, University of Crete, Heraklion, Greece. FAU - Kogevinas, Manolis AU - Kogevinas M AD - ISGlobal, Barcelona, Spain. AD - Universitat Pompeu Fabra, Barcelona, Spain. AD - CIBER Epidemiologia y Salud Publica, Barcelona, Spain. FAU - Chatzi, Leda AU - Chatzi L AD - Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA. FAU - Vafeiadi, Marina AU - Vafeiadi M AUID- ORCID: 0000-0002-6143-7172 AD - Department of Social Medicine, Faculty of Medicine, University of Crete, Heraklion, Greece. LA - eng GR - R01 ES030691/ES/NIEHS NIH HHS/United States GR - R01 ES029944/ES/NIEHS NIH HHS/United States GR - R01 ES030364/ES/NIEHS NIH HHS/United States GR - R21 ES028903/ES/NIEHS NIH HHS/United States GR - R21 ES029681/ES/NIEHS NIH HHS/United States GR - P30 ES007048/ES/NIEHS NIH HHS/United States PT - Journal Article PT - Research Support, N.I.H., Extramural PT - Research Support, Non-U.S. Gov't DEP - 20211203 PL - England TA - J Dev Orig Health Dis JT - Journal of developmental origins of health and disease JID - 101517692 RN - 0 (Environmental Pollutants) RN - 4M7FS82U08 (Dichlorodiphenyl Dichloroethylene) RN - 4Z87H0LKUY (Hexachlorobenzene) RN - DFC2HB4I0K (Polychlorinated Biphenyls) SB - IM MH - Animals MH - *Asthma/epidemiology/etiology MH - Dichlorodiphenyl Dichloroethylene/adverse effects MH - Environmental Exposure/adverse effects MH - *Environmental Pollutants/adverse effects MH - Female MH - Greece/epidemiology MH - Hexachlorobenzene/adverse effects MH - Humans MH - *Hypersensitivity/epidemiology/etiology MH - Male MH - Mother-Child Relations MH - Persistent Organic Pollutants MH - *Polychlorinated Biphenyls/adverse effects MH - Pregnancy MH - *Prenatal Exposure Delayed Effects/chemically induced/epidemiology MH - Prospective Studies MH - Respiratory Sounds/etiology MH - *Rheiformes OTO - NOTNLM OT - DDE OT - HCB OT - PCB OT - allergic disease EDAT- 2021/12/04 06:00 MHDA- 2022/09/09 06:00 CRDT- 2021/12/03 08:42 PHST- 2021/12/04 06:00 [pubmed] PHST- 2022/09/09 06:00 [medline] PHST- 2021/12/03 08:42 [entrez] AID - S2040174421000660 [pii] AID - 10.1017/S2040174421000660 [doi] PST - ppublish SO - J Dev Orig Health Dis. 2022 Oct;13(5):566-574. doi: 10.1017/S2040174421000660. Epub 2021 Dec 3.