PMID- 3486025
OWN - NLM
STAT- MEDLINE
DCOM- 19860613
LR  - 20190614
IS  - 0006-8993 (Print)
IS  - 0006-8993 (Linking)
VI  - 369
IP  - 1-2
DP  - 1986 Mar 26
TI  - Vasoactive intestinal polypeptide nullifies cytochrome reduction response to 
      afferent activation of the perfused bullfrog brain.
PG  - 275-84
AB  - Redox states of cytochromes a(a3), b and c+c1 were continuously measured on the 
      surface of the cerebral hemisphere of the perfused bullfrog brain with the aid of 
      a scanning organ spectrophotometer. To correlate with changes of the redox state, 
      electrical activity of the brain was simultaneously recorded in the vicinity of 
      the tip of the light guide of the spectrophotometer. Electrical stimulation of 
      the third dorsal root of the spinal cord induced parallel reduction of the 
      cytochromes and burst activity in the brain. Intracerebroventricular (i.c.v.) 
      infusion of vasoactive intestinal polypeptide (VIP; 30 pmol/100 g body weight) 
      nullified the cytochrome reduction induced by the electrical stimulation of the 
      dorsal root, but did not attenuate the burst activity. The i.c.v. infusion of VIP 
      (30 pmol/100 g b.wt.) per se had little if any influence upon both redox state 
      and burst activity. The infusion of 1 nM VIP into the internal carotid arteries 
      also nullified the cytochrome reduction response to the afferent electrical 
      activation. The present results provide evidence that one of the physiological 
      roles of the VIPergic neurons in the brain may be to balance the redox states of 
      electron transfer systems in neurons.
FAU - Kanno, T
AU  - Kanno T
FAU - Saito, T
AU  - Saito T
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - Brain Res
JT  - Brain research
JID - 0045503
RN  - 0 (Cytochromes)
RN  - 0U46U6E8UK (NAD)
RN  - 37221-79-7 (Vasoactive Intestinal Peptide)
SB  - IM
MH  - Animals
MH  - Blood-Brain Barrier
MH  - Brain/*drug effects/metabolism
MH  - Cytochromes/*metabolism
MH  - Female
MH  - Injections, Intraventricular
MH  - Male
MH  - NAD/metabolism
MH  - Oxidation-Reduction/drug effects
MH  - Rana catesbeiana
MH  - Spectrophotometry
MH  - Vasoactive Intestinal Peptide/*pharmacology
EDAT- 1986/03/26 00:00
MHDA- 1986/03/26 00:01
CRDT- 1986/03/26 00:00
PHST- 1986/03/26 00:00 [pubmed]
PHST- 1986/03/26 00:01 [medline]
PHST- 1986/03/26 00:00 [entrez]
AID - 0006-8993(86)90536-6 [pii]
AID - 10.1016/0006-8993(86)90536-6 [doi]
PST - ppublish
SO  - Brain Res. 1986 Mar 26;369(1-2):275-84. doi: 10.1016/0006-8993(86)90536-6.