PMID- 34861232
OWN - NLM
STAT- MEDLINE
DCOM- 20220329
LR  - 20220531
IS  - 1096-0953 (Electronic)
IS  - 0013-9351 (Linking)
VI  - 205
DP  - 2022 Apr 1
TI  - Association of both prenatal and early childhood multiple metals exposure with 
      neurodevelopment in infant: A prospective cohort study.
PG  - 112450
LID - S0013-9351(21)01751-5 [pii]
LID - 10.1016/j.envres.2021.112450 [doi]
AB  - BACKGROUND: Impaired neurodevelopment of children has become a growing public 
      concern; however, the associations between metals exposure and neurocognitive 
      function have remained largely unknown. OBJECTIVES: We systematically evaluated 
      the associations of multiple metals exposure during pregnancy and childhood on 
      the neurodevelopment of children aged 2-3 years. METHODS: We measured 22 metals 
      in the serum and urine among703 mother-child pairs from the Guangxi Birth Cohort 
      Study. The neurocognitive development of children was assessed by the Gesell 
      Development Diagnosis Scale (GDDS; Chinese version). Multiple linear regression 
      models were used to evaluate the relationship between the metals (selected by 
      elastic net regression) and the outcomes. The Bayesian kernel machine regression 
      (BKMR) was used to evaluate the possible joint effect between the multiple metal 
      mixture and the outcomes. RESULTS: Prenatal aluminum (Al) exposure was negatively 
      associated with the fine motor developmental quotient (DQ) (beta = -1.545, 95%CI: 
      2.231, -0.859), adaption DQ (beta = -1.182, 95%CI: 1.632, -0.732), language DQ 
      (beta = -1.284, 95% CI: 1.758, -0.809), and social DQ (beta = -1.729, 95% CI: 2.406, 
      -1.052) in the multi-metal model. Prenatal cadmium (Cd) exposure was negatively 
      associated with gross motor DQ (beta = -2.524, 95% CI: 4.060, -0.988), while 
      postpartum Cd exposure was negatively associated with language DQ (beta = -1.678, 
      95% CI: 3.227, -0.129). In stratified analyses, infants of different sexes had 
      different sensitivities to metal exposure, and neurobehavioral development was 
      more significantly affected by metal exposure in the first and second trimester. 
      BKMR analysis revealed a negative joint effect of the Al, Cd, and selenium (Se) 
      on the language DQ score; postpartum Cd exposure played a major role in this 
      relationship. CONCLUSION: Prenatal exposure to Al, Ba, Cd, molybdenum (Mo), lead 
      (Pb), antimony (Sb), and strontium (Sr), and postpartum exposure to cobalt (Co), 
      Cd, stannum (Sn), iron (Fe), nickel (Ni), and Se are associated with neurological 
      development of infants. The first and second trimester might be the most 
      sensitive period when metal exposure affects neurodevelopment.
CI  - Copyright (c) 2021. Published by Elsevier Inc.
FAU - Liu, Chaoqun
AU  - Liu C
AD  - Center for Genomic and Personalized Medicine, Guangxi Key Laboratory for Genomic 
      and Personalized Medicine, Guangxi Collaborative Innovation Center for Genomic 
      and Personalized Medicine, Guangxi Medical University, 530021, Nanning, Guangxi, 
      China; Department of Nutrition and Food Hygiene, School of Public Health, Guangxi 
      Medical University, 530021, Nanning, Guangxi, China; Department of Public Health, 
      School of Medicine, Guangxi University of Science and Technology, Liuzhou, 
      545006, Guangxi, China.
FAU - Huang, Lulu
AU  - Huang L
AD  - Center for Genomic and Personalized Medicine, Guangxi Key Laboratory for Genomic 
      and Personalized Medicine, Guangxi Collaborative Innovation Center for Genomic 
      and Personalized Medicine, Guangxi Medical University, 530021, Nanning, Guangxi, 
      China; Department of Public Health, School of Medicine, Guangxi University of 
      Science and Technology, Liuzhou, 545006, Guangxi, China; Department of 
      Occupational Health and Environmental Health, School of Public Health, Guangxi 
      Medical University, 530021, Nanning, Guangxi, China.
FAU - Huang, Shengzhu
AU  - Huang S
AD  - Center for Genomic and Personalized Medicine, Guangxi Key Laboratory for Genomic 
      and Personalized Medicine, Guangxi Collaborative Innovation Center for Genomic 
      and Personalized Medicine, Guangxi Medical University, 530021, Nanning, Guangxi, 
      China.
FAU - Wei, Luyun
AU  - Wei L
AD  - Center for Genomic and Personalized Medicine, Guangxi Key Laboratory for Genomic 
      and Personalized Medicine, Guangxi Collaborative Innovation Center for Genomic 
      and Personalized Medicine, Guangxi Medical University, 530021, Nanning, Guangxi, 
      China.
FAU - Cao, Dehao
AU  - Cao D
AD  - Center for Genomic and Personalized Medicine, Guangxi Key Laboratory for Genomic 
      and Personalized Medicine, Guangxi Collaborative Innovation Center for Genomic 
      and Personalized Medicine, Guangxi Medical University, 530021, Nanning, Guangxi, 
      China.
FAU - Zan, Gaohui
AU  - Zan G
AD  - Center for Genomic and Personalized Medicine, Guangxi Key Laboratory for Genomic 
      and Personalized Medicine, Guangxi Collaborative Innovation Center for Genomic 
      and Personalized Medicine, Guangxi Medical University, 530021, Nanning, Guangxi, 
      China; Department of Occupational Health and Environmental Health, School of 
      Public Health, Guangxi Medical University, 530021, Nanning, Guangxi, China.
FAU - Tan, Yanli
AU  - Tan Y
AD  - Center for Genomic and Personalized Medicine, Guangxi Key Laboratory for Genomic 
      and Personalized Medicine, Guangxi Collaborative Innovation Center for Genomic 
      and Personalized Medicine, Guangxi Medical University, 530021, Nanning, Guangxi, 
      China; Department of Occupational Health and Environmental Health, School of 
      Public Health, Guangxi Medical University, 530021, Nanning, Guangxi, China.
FAU - Wang, Sida
AU  - Wang S
AD  - Department of Medical Ultrasonics, The First Affiliated Hospital of Guangxi 
      Medical University, Nanning, 530021, Guangxi Province, China.
FAU - Yang, Minjing
AU  - Yang M
AD  - Department of Pediatrics, The First Affiliated Hospital of Guangxi Medical 
      University, Nanning, 530021, Guangxi Province, China.
FAU - Tian, Long
AU  - Tian L
AD  - Department of Science and Education, Maternal & Child Health Hospital of Qinzhou, 
      Qinzhou, Guangxi, China.
FAU - Tang, Weijun
AU  - Tang W
AD  - Center for Translational Medicine, Maternal & Child Health Hospital of Qinzhou, 
      Qinzhou, Guangxi, China.
FAU - He, Caitong
AU  - He C
AD  - Department of Science and Education, Maternal & Child Health Hospital of Yulin, 
      Yulin, Guangxi, China.
FAU - Shen, Chunhua
AU  - Shen C
AD  - Liuzhou Maternity and Child Healthcare Hospital, Liuzhou Institute of 
      Reproduction and Genetics, Affiliated Maternity Hospital and Affiliated 
      Children's Hospital of Guangxi University of Science and Technology, Liuzhou, 
      Guangxi, China.
FAU - Luo, Bangzhu
AU  - Luo B
AD  - Department of Medical Services Section, Maternal & Child Health Hospital of 
      Guigang, Guigang, Guangxi, China.
FAU - Zhu, Maoling
AU  - Zhu M
AD  - Department of Obstetrics, Maternal & Child Health Hospital of Nanning, Nanning, 
      Guangxi, China.
FAU - Liang, Tao
AU  - Liang T
AD  - Department of Pediatrics, Maternal & Child Health Hospital of Wuzhou, Wuzhou, 
      Guangxi, China.
FAU - Pang, Baohong
AU  - Pang B
AD  - Department of Women Health Care, Maternal & Child Health Hospital of Yuzhou, 
      Yulin, Guangxi, China.
FAU - Li, Mujun
AU  - Li M
AD  - Department of Reproductive Center, First Affiliated Hospital of Guangxi Medical 
      University, Nanning, China.
FAU - Mo, Zengnan
AU  - Mo Z
AD  - Center for Genomic and Personalized Medicine, Guangxi Key Laboratory for Genomic 
      and Personalized Medicine, Guangxi Collaborative Innovation Center for Genomic 
      and Personalized Medicine, Guangxi Medical University, 530021, Nanning, Guangxi, 
      China; Department of Urology and Nephrology, First Affiliated Hospital of Guangxi 
      Medical University, Nanning, China.
FAU - Yang, Xiaobo
AU  - Yang X
AD  - Center for Genomic and Personalized Medicine, Guangxi Key Laboratory for Genomic 
      and Personalized Medicine, Guangxi Collaborative Innovation Center for Genomic 
      and Personalized Medicine, Guangxi Medical University, 530021, Nanning, Guangxi, 
      China; Department of Public Health, School of Medicine, Guangxi University of 
      Science and Technology, Liuzhou, 545006, Guangxi, China; Department of 
      Occupational Health and Environmental Health, School of Public Health, Guangxi 
      Medical University, 530021, Nanning, Guangxi, China. Electronic address: 
      yangx@gxmu.edu.cn.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20211130
PL  - Netherlands
TA  - Environ Res
JT  - Environmental research
JID - 0147621
RN  - 0 (Metals)
SB  - IM
MH  - Bayes Theorem
MH  - Child, Preschool
MH  - China
MH  - Cohort Studies
MH  - Female
MH  - Humans
MH  - Infant
MH  - *Metals/toxicity
MH  - Pregnancy
MH  - Prospective Studies
OTO - NOTNLM
OT  - Compound exposure
OT  - Gesell
OT  - Metal
OT  - Neurodevelopment
EDAT- 2021/12/04 06:00
MHDA- 2022/03/30 06:00
CRDT- 2021/12/03 20:12
PHST- 2021/04/27 00:00 [received]
PHST- 2021/10/15 00:00 [revised]
PHST- 2021/11/24 00:00 [accepted]
PHST- 2021/12/04 06:00 [pubmed]
PHST- 2022/03/30 06:00 [medline]
PHST- 2021/12/03 20:12 [entrez]
AID - S0013-9351(21)01751-5 [pii]
AID - 10.1016/j.envres.2021.112450 [doi]
PST - ppublish
SO  - Environ Res. 2022 Apr 1;205:112450. doi: 10.1016/j.envres.2021.112450. Epub 2021 
      Nov 30.