PMID- 34862421
OWN - NLM
STAT- MEDLINE
DCOM- 20220126
LR  - 20230209
IS  - 2055-5008 (Electronic)
IS  - 2055-5008 (Linking)
VI  - 7
IP  - 1
DP  - 2021 Dec 3
TI  - Time-restricted feeding induces Lactobacillus- and Akkermansia-specific 
      functional changes in the rat fecal microbiota.
PG  - 85
LID - 10.1038/s41522-021-00256-x [doi]
LID - 85
AB  - Diet is a key factor influencing gut microbiota (GM) composition and functions, 
      which in turn affect host health. Among dietary regimens, time-restricted (TR) 
      feeding has been associated to numerous health benefits. The impact of TR feeding 
      on the GM composition has been mostly explored by means of metagenomic 
      sequencing. To date, however, little is known about the modulation of GM 
      functions by this dietary regimen. Here, we analyzed the effects of TR feeding on 
      GM functions by evaluating protein expression changes in a rat model through a 
      metaproteomic approach. We observed that TR feeding has a relevant impact on GM 
      functions, specifically leading to an increased abundance of several enzymes 
      involved in carbohydrate and protein metabolism and expressed by Lactobacillus 
      spp. and Akkermansia muciniphila. Taken together, these results contribute to 
      deepening our knowledge about the key relationship between diet, GM, and health.
CI  - (c) 2021. The Author(s).
FAU - Palomba, Antonio
AU  - Palomba A
AUID- ORCID: 0000-0001-7380-2934
AD  - Porto Conte Ricerche Srl, Science and Technology Park of Sardinia, Alghero, 
      Italy.
FAU - Tanca, Alessandro
AU  - Tanca A
AUID- ORCID: 0000-0002-6066-7048
AD  - Porto Conte Ricerche Srl, Science and Technology Park of Sardinia, Alghero, 
      Italy.
AD  - Department of Biomedical Sciences, University of Sassari, Sassari, Italy.
FAU - Abbondio, Marcello
AU  - Abbondio M
AUID- ORCID: 0000-0003-2126-4817
AD  - Department of Biomedical Sciences, University of Sassari, Sassari, Italy.
FAU - Sau, Rosangela
AU  - Sau R
AD  - Department of Biomedical Sciences, University of Sassari, Sassari, Italy.
FAU - Serra, Monica
AU  - Serra M
AD  - Department of Biomedical Sciences, University of Cagliari, Cagliari, Italy.
FAU - Marongiu, Fabio
AU  - Marongiu F
AD  - Department of Biomedical Sciences, University of Cagliari, Cagliari, Italy.
FAU - Fraumene, Cristina
AU  - Fraumene C
AD  - Porto Conte Ricerche Srl, Science and Technology Park of Sardinia, Alghero, 
      Italy.
FAU - Pagnozzi, Daniela
AU  - Pagnozzi D
AD  - Porto Conte Ricerche Srl, Science and Technology Park of Sardinia, Alghero, 
      Italy.
FAU - Laconi, Ezio
AU  - Laconi E
AD  - Department of Biomedical Sciences, University of Cagliari, Cagliari, Italy.
FAU - Uzzau, Sergio
AU  - Uzzau S
AUID- ORCID: 0000-0001-6246-2794
AD  - Porto Conte Ricerche Srl, Science and Technology Park of Sardinia, Alghero, 
      Italy. uzzau@uniss.it.
AD  - Department of Biomedical Sciences, University of Sassari, Sassari, Italy. 
      uzzau@uniss.it.
LA  - eng
GR  - FAR 2019/2020/Universita degli Studi di Sassari (University of Sassari)/
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20211203
PL  - United States
TA  - NPJ Biofilms Microbiomes
JT  - NPJ biofilms and microbiomes
JID - 101666944
SB  - IM
MH  - Akkermansia
MH  - Animals
MH  - *Gastrointestinal Microbiome
MH  - Lactobacillus
MH  - *Microbiota
MH  - Rats
MH  - Verrucomicrobia
PMC - PMC8642412
COIS- The authors declare no competing interests.
EDAT- 2021/12/05 06:00
MHDA- 2022/01/27 06:00
PMCR- 2021/12/03
CRDT- 2021/12/04 05:52
PHST- 2021/03/10 00:00 [received]
PHST- 2021/11/03 00:00 [accepted]
PHST- 2021/12/04 05:52 [entrez]
PHST- 2021/12/05 06:00 [pubmed]
PHST- 2022/01/27 06:00 [medline]
PHST- 2021/12/03 00:00 [pmc-release]
AID - 10.1038/s41522-021-00256-x [pii]
AID - 256 [pii]
AID - 10.1038/s41522-021-00256-x [doi]
PST - epublish
SO  - NPJ Biofilms Microbiomes. 2021 Dec 3;7(1):85. doi: 10.1038/s41522-021-00256-x.