PMID- 34864016 OWN - NLM STAT- MEDLINE DCOM- 20220111 LR - 20220111 IS - 1879-1298 (Electronic) IS - 0045-6535 (Linking) VI - 289 DP - 2022 Feb TI - Associations of blood and urinary heavy metals with rheumatoid arthritis risk among adults in NHANES, 1999-2018. PG - 133147 LID - S0045-6535(21)03619-5 [pii] LID - 10.1016/j.chemosphere.2021.133147 [doi] AB - Heavy metals exposure has been widely recognized as a risk factor for human health. However, limited information is available about the impacts of heavy metals on rheumatoid arthritis (RA). Herein, we estimated the associations of 3 blood and 11 urinary metals with the risk of RA among 49830 U.S. adults from the National Health and Nutrition Examination Survey (NHANES), 1999-2018. In the single-exposure model, blood cadmium (Cd) and lead (Pb), urinary Cd, Pb, antimony (Sb), tungsten (Tu), and uranium (Ur) were identified to be positively associated with RA risk. Furthermore, weighted quantile sum (WQS) regression, quantile-based g computation (qgcomp), and Bayesian kernel machine regression (BKMR) analyses consistently showed that both blood and urinary metals-mixed exposure were positively correlated with the risk of RA, and highlighted that Cd and Pb were responsible for the outcomes. Such associations were more evident in the young and middle-aged population. These findings indicated that exposure to heavy metals increased RA risk, and advanced the identification of risk factors for RA. CI - Copyright (c) 2021 Elsevier Ltd. All rights reserved. FAU - Chen, Li AU - Chen L AD - Department of Nutrition and Food Hygiene, Hubei Key Laboratory of Food Nutrition and Safety, Ministry of Education Key Laboratory of Environment and Health and MOE Key Lab of Environment and Health, Key Laboratory of Environment and Health (Wuhan), Ministry of Environmental Protection, State Key Laboratory of Environment Health (Incubation), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China. FAU - Sun, Qiuzi AU - Sun Q AD - Yancheng Center for Disease Control and Prevention, Yancheng, China. FAU - Peng, Shufen AU - Peng S AD - Department of Nutrition and Food Hygiene, Hubei Key Laboratory of Food Nutrition and Safety, Ministry of Education Key Laboratory of Environment and Health and MOE Key Lab of Environment and Health, Key Laboratory of Environment and Health (Wuhan), Ministry of Environmental Protection, State Key Laboratory of Environment Health (Incubation), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China. FAU - Tan, Tianqi AU - Tan T AD - Department of Nutrition and Food Hygiene, Hubei Key Laboratory of Food Nutrition and Safety, Ministry of Education Key Laboratory of Environment and Health and MOE Key Lab of Environment and Health, Key Laboratory of Environment and Health (Wuhan), Ministry of Environmental Protection, State Key Laboratory of Environment Health (Incubation), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China. FAU - Mei, Guibin AU - Mei G AD - Department of Nutrition and Food Hygiene, Hubei Key Laboratory of Food Nutrition and Safety, Ministry of Education Key Laboratory of Environment and Health and MOE Key Lab of Environment and Health, Key Laboratory of Environment and Health (Wuhan), Ministry of Environmental Protection, State Key Laboratory of Environment Health (Incubation), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China. FAU - Chen, Huimin AU - Chen H AD - Department of Nutrition and Food Hygiene, Hubei Key Laboratory of Food Nutrition and Safety, Ministry of Education Key Laboratory of Environment and Health and MOE Key Lab of Environment and Health, Key Laboratory of Environment and Health (Wuhan), Ministry of Environmental Protection, State Key Laboratory of Environment Health (Incubation), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China. FAU - Zhao, Ying AU - Zhao Y AD - Department of Nutrition and Food Hygiene, Hubei Key Laboratory of Food Nutrition and Safety, Ministry of Education Key Laboratory of Environment and Health and MOE Key Lab of Environment and Health, Key Laboratory of Environment and Health (Wuhan), Ministry of Environmental Protection, State Key Laboratory of Environment Health (Incubation), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China. FAU - Yao, Ping AU - Yao P AD - Department of Nutrition and Food Hygiene, Hubei Key Laboratory of Food Nutrition and Safety, Ministry of Education Key Laboratory of Environment and Health and MOE Key Lab of Environment and Health, Key Laboratory of Environment and Health (Wuhan), Ministry of Environmental Protection, State Key Laboratory of Environment Health (Incubation), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China. FAU - Tang, Yuhan AU - Tang Y AD - Department of Nutrition and Food Hygiene, Hubei Key Laboratory of Food Nutrition and Safety, Ministry of Education Key Laboratory of Environment and Health and MOE Key Lab of Environment and Health, Key Laboratory of Environment and Health (Wuhan), Ministry of Environmental Protection, State Key Laboratory of Environment Health (Incubation), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China. Electronic address: 2015220157@hust.edu.cn. LA - eng PT - Journal Article DEP - 20211202 PL - England TA - Chemosphere JT - Chemosphere JID - 0320657 RN - 0 (Metals, Heavy) RN - 00BH33GNGH (Cadmium) RN - 4OC371KSTK (Uranium) SB - IM MH - Adult MH - *Arthritis, Rheumatoid/chemically induced/epidemiology MH - Bayes Theorem MH - Cadmium MH - Humans MH - *Metals, Heavy MH - Middle Aged MH - Nutrition Surveys MH - *Uranium OTO - NOTNLM OT - Heavy metals OT - Joint exposure OT - NHANES OT - Rheumatoid arthritis EDAT- 2021/12/06 06:00 MHDA- 2022/01/12 06:00 CRDT- 2021/12/05 21:03 PHST- 2021/08/23 00:00 [received] PHST- 2021/11/07 00:00 [revised] PHST- 2021/11/30 00:00 [accepted] PHST- 2021/12/06 06:00 [pubmed] PHST- 2022/01/12 06:00 [medline] PHST- 2021/12/05 21:03 [entrez] AID - S0045-6535(21)03619-5 [pii] AID - 10.1016/j.chemosphere.2021.133147 [doi] PST - ppublish SO - Chemosphere. 2022 Feb;289:133147. doi: 10.1016/j.chemosphere.2021.133147. Epub 2021 Dec 2.