PMID- 3486441
OWN - NLM
STAT- MEDLINE
DCOM- 19860612
LR  - 20090129
IS  - 0161-8105 (Print)
IS  - 0161-8105 (Linking)
VI  - 9
IP  - 1 Pt 2
DP  - 1986
TI  - Immune factors in narcolepsy.
PG  - 143-8
AB  - Most but not all subjects with the narcoleptic syndrome have the human leukocyte 
      antigen (HLA) DR2 (and DQ1). The narcolepsy-DR2 association is the highest 
      disease-HLA linkage known, and occurs in nonfamilial as well as familial cases of 
      the narcoleptic syndrome. In other forms of daytime drowsiness, there is no 
      relationship with a specific HLA, although some subjects considered to have 
      "essential" hypersomnolence probably have the narcoleptic syndrome. The cause of 
      the narcoleptic syndrome remains unknown, although in a few instances the 
      condition follows infection. There is no evidence for a circulating sleep factor 
      in the blood or in the cerebrospinal fluid of narcoleptic subjects, and no 
      unequivocal marker of cellular immunity has yet been found. However, a few 
      subjects with the narcoleptic syndrome have oligoclonal bands or raised 
      immunoglobulin concentration in the cerebrospinal fluid. It is highly likely that 
      the narcoleptic syndrome is an immune-mediated disorder, occurring in a 
      genetically susceptible (DR2/DQ1-positive) subject.
FAU - Langdon, N
AU  - Langdon N
FAU - Lock, C
AU  - Lock C
FAU - Welsh, K
AU  - Welsh K
FAU - Vergani, D
AU  - Vergani D
FAU - Dorow, R
AU  - Dorow R
FAU - Wachtel, H
AU  - Wachtel H
FAU - Palenschat, D
AU  - Palenschat D
FAU - Parkes, J D
AU  - Parkes JD
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Sleep
JT  - Sleep
JID - 7809084
RN  - 0 (Glycopeptides)
RN  - 0 (HLA-DQ Antigens)
RN  - 0 (HLA-DR2 Antigen)
RN  - 0 (Histocompatibility Antigens Class II)
RN  - 0 (Immunoglobulins)
SB  - IM
MH  - Female
MH  - Glycopeptides/analysis
MH  - HLA-DQ Antigens
MH  - HLA-DR2 Antigen
MH  - Histocompatibility Antigens Class II/*analysis
MH  - Humans
MH  - Immunoglobulins/cerebrospinal fluid
MH  - Male
MH  - Middle Aged
MH  - Narcolepsy/genetics/*immunology
EDAT- 1986/01/01 00:00
MHDA- 1986/01/01 00:01
CRDT- 1986/01/01 00:00
PHST- 1986/01/01 00:00 [pubmed]
PHST- 1986/01/01 00:01 [medline]
PHST- 1986/01/01 00:00 [entrez]
PST - ppublish
SO  - Sleep. 1986;9(1 Pt 2):143-8.