PMID- 34864668
OWN - NLM
STAT- MEDLINE
DCOM- 20220228
LR  - 20220304
IS  - 1875-8908 (Electronic)
IS  - 1387-2877 (Print)
IS  - 1387-2877 (Linking)
VI  - 85
IP  - 2
DP  - 2022
TI  - A Comparison of Behavioral and Psychological Symptoms of Dementia (BPSD) and BPSD 
      Sub-Syndromes in Early-Onset and Late-Onset Alzheimer's Disease.
PG  - 691-699
LID - 10.3233/JAD-215061 [doi]
AB  - BACKGROUND: Behavioral and psychological symptoms of dementia (BPSD) have a large 
      impact on the quality of life of patients with Alzheimer's disease (AD). Few 
      studies have compared BPSD between early-onset (EOAD) and late-onset (LOAD) 
      patients, finding conflicting results. OBJECTIVE: The aims of this study were to: 
      1) characterize the presence, overall prevalence, and time of occurrence of BPSD 
      in EOAD versus LOAD; 2) estimate the prevalence over time and severity of each 
      BPSD in EOAD versus LOAD in three stages: pre-T0 (before the onset of the 
      disease), T0 (from onset to 5 years), and T1 (from 5 years onwards); 3) track the 
      manifestation of BPSD sub-syndromes (i.e., hyperactivity, psychosis, affective, 
      and apathy) in EOAD versus LOAD at T0 and T1. METHODS: The sample includes 1,538 
      LOAD and 387 EOAD diagnosed from 1996 to 2018. Comprehensive assessment 
      batteries, including the Neuropsychiatric Inventory (NPI), were administered at 
      the first medical assessment and at different follow-up period. RESULTS: The 
      overall prevalence for the most of BPSD was significantly higher in EOAD compared 
      to LOAD whereas most BPSD appeared significantly later in EOAD patients. Between 
      the two groups, from pre-T0 to T1 we recorded a different pattern of BPSD 
      prevalence over time as well as for BPSD sub-syndromes at T0 and T1. Results on 
      severity of BPSD did not show significant differences. CONCLUSION: EOAD and LOAD 
      represent two different forms of a single entity not only from a 
      neuropathological, cognitive, and functional level but also from a psychiatric 
      point of view.
FAU - Altomari, Natalia
AU  - Altomari N
AD  - Department of Mathematics and Computer Science, University of Calabria, Rende 
      (CS), Italy.
FAU - Bruno, Francesco
AU  - Bruno F
AD  - Regional Neurogenetic Centre (CRN), Department of Primary Care, ASP Catanzaro, 
      Lamezia Terme (CZ), Italy.
FAU - Lagana, Valentina
AU  - Lagana V
AD  - Regional Neurogenetic Centre (CRN), Department of Primary Care, ASP Catanzaro, 
      Lamezia Terme (CZ), Italy.
FAU - Smirne, Nicoletta
AU  - Smirne N
AD  - Regional Neurogenetic Centre (CRN), Department of Primary Care, ASP Catanzaro, 
      Lamezia Terme (CZ), Italy.
FAU - Colao, Rosanna
AU  - Colao R
AD  - Regional Neurogenetic Centre (CRN), Department of Primary Care, ASP Catanzaro, 
      Lamezia Terme (CZ), Italy.
FAU - Curcio, Sabrina
AU  - Curcio S
AD  - Regional Neurogenetic Centre (CRN), Department of Primary Care, ASP Catanzaro, 
      Lamezia Terme (CZ), Italy.
FAU - Di Lorenzo, Raffaele
AU  - Di Lorenzo R
AD  - Regional Neurogenetic Centre (CRN), Department of Primary Care, ASP Catanzaro, 
      Lamezia Terme (CZ), Italy.
FAU - Frangipane, Francesca
AU  - Frangipane F
AD  - Regional Neurogenetic Centre (CRN), Department of Primary Care, ASP Catanzaro, 
      Lamezia Terme (CZ), Italy.
FAU - Maletta, Raffaele
AU  - Maletta R
AD  - Regional Neurogenetic Centre (CRN), Department of Primary Care, ASP Catanzaro, 
      Lamezia Terme (CZ), Italy.
FAU - Puccio, Gianfranco
AU  - Puccio G
AD  - Regional Neurogenetic Centre (CRN), Department of Primary Care, ASP Catanzaro, 
      Lamezia Terme (CZ), Italy.
FAU - Bruni, Amalia Cecilia
AU  - Bruni AC
AD  - Regional Neurogenetic Centre (CRN), Department of Primary Care, ASP Catanzaro, 
      Lamezia Terme (CZ), Italy.
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - Netherlands
TA  - J Alzheimers Dis
JT  - Journal of Alzheimer's disease : JAD
JID - 9814863
SB  - IM
MH  - Affective Symptoms/psychology
MH  - Age of Onset
MH  - Aged
MH  - Aged, 80 and over
MH  - Alzheimer Disease/*psychology
MH  - Apathy
MH  - Behavioral Symptoms/*psychology
MH  - Dementia/complications/diagnosis/psychology
MH  - Female
MH  - Humans
MH  - Italy
MH  - Male
MH  - Middle Aged
MH  - Neuropsychological Tests/*statistics & numerical data
MH  - Psychiatric Status Rating Scales
MH  - Psychomotor Agitation/psychology
MH  - Psychotic Disorders/psychology
MH  - Severity of Illness Index
PMC - PMC8842787
OTO - NOTNLM
OT  - Alzheimer's disease
OT  - BPSD sub-syndromes
OT  - Neuropsychiatric Inventory
OT  - behavioral and psychological symptoms of dementia (BPSD)
OT  - early-onset Alzheimer's disease
OT  - late-onset Alzheimer's disease
OT  - prevalence
OT  - prevalence over time
OT  - time of occurrence
COIS- Authors' disclosures available online 
      (https://www.j-alz.com/manuscript-disclosures/21-5061r1).
EDAT- 2021/12/06 06:00
MHDA- 2022/03/01 06:00
PMCR- 2022/02/14
CRDT- 2021/12/05 21:31
PHST- 2021/12/06 06:00 [pubmed]
PHST- 2022/03/01 06:00 [medline]
PHST- 2021/12/05 21:31 [entrez]
PHST- 2022/02/14 00:00 [pmc-release]
AID - JAD215061 [pii]
AID - 10.3233/JAD-215061 [doi]
PST - ppublish
SO  - J Alzheimers Dis. 2022;85(2):691-699. doi: 10.3233/JAD-215061.