PMID- 34866567
OWN - NLM
STAT- MEDLINE
DCOM- 20230810
LR  - 20230810
IS  - 1469-2198 (Electronic)
IS  - 0954-5794 (Linking)
VI  - 35
IP  - 3
DP  - 2023 Aug
TI  - Empirically-identified subgroups of children with autism spectrum disorder and 
      their response to two types of cognitive behavioral therapy.
PG  - 1188-1202
LID - 10.1017/S0954579421001115 [doi]
AB  - Autism spectrum disorder (ASD) is heterogeneous and likely entails distinct 
      phenotypes with varying etiologies. Identifying these subgroups may contribute to 
      hypotheses about differential treatment responses. The present study aimed to 
      discern subgroups among children with ASD and anxiety in context of the 
      five-factor model of personality (FFM) and evaluate treatment response 
      differences to two cognitive-behavioral therapy treatments. The present study is 
      a secondary data analysis of children with ASD and anxiety (N=202; ages 7-13; 
      20.8% female) in a cognitive behavioral therapy (CBT) randomized controlled trial 
      (Wood et al., 2020). Subgroups were identified via latent profile analysis of 
      parent-reported FFM data. Treatment groups included standard-of-practice CBT 
      (CC), designed for children with anxiety, and adapted CBT (BIACA), designed for 
      children with ASD and comorbid anxiety. Five subgroups with distinct profiles 
      were extracted. Analysis of covariance revealed CBT response was contingent on 
      subgroup membership. Two subgroups responded better to BIACA on the primary 
      outcome measure and a third responded better to BIACA on a peer-social adaptation 
      measure, while a fourth subgroup responded better to CC on a school-related 
      adaptation measure. These findings suggest that the FFM may be useful in 
      empirically identifying subgroups of children with ASD, which could inform 
      intervention selection decisions for children with ASD and anxiety.
FAU - Cho, Anchuen
AU  - Cho A
AUID- ORCID: 0000-0001-9848-8689
AD  - University of California, Los Angeles, 405 Hilgard Ave., 3132A Moore Hall, Los 
      Angeles, CA90095, USA.
FAU - Wood, Jeffrey J
AU  - Wood JJ
AD  - University of California, Los Angeles, 405 Hilgard Ave., 3132A Moore Hall, Los 
      Angeles, CA90095, USA.
FAU - Ferrer, Emilio
AU  - Ferrer E
AD  - University of California, Davis, 1 Shields Ave., 135 Young Hall, Davis, CA95616, 
      USA.
FAU - Rosenau, Kashia
AU  - Rosenau K
AD  - University of California, Los Angeles, 405 Hilgard Ave., 3132A Moore Hall, Los 
      Angeles, CA90095, USA.
FAU - Storch, Eric A
AU  - Storch EA
AD  - Baylor College of Medicine, 7200 Cambridge St, Houston, TX77030, USA.
FAU - Kendall, Philip C
AU  - Kendall PC
AD  - Temple University, 1701 North 13th St., Weiss Hall, Philadelphia, PA19122, USA.
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
DEP - 20211206
PL  - United States
TA  - Dev Psychopathol
JT  - Development and psychopathology
JID - 8910645
SB  - IM
MH  - Child
MH  - Humans
MH  - Female
MH  - Male
MH  - *Autism Spectrum Disorder/therapy/psychology
MH  - *Cognitive Behavioral Therapy
MH  - Anxiety Disorders/psychology
MH  - Anxiety
MH  - Comorbidity
MH  - Treatment Outcome
OTO - NOTNLM
OT  - autism spectrum disorder
OT  - cognitive behavioral therapy
OT  - five-factor model of personality
OT  - latent profile analysis
OT  - treatment response
EDAT- 2021/12/07 06:00
MHDA- 2023/08/10 06:43
CRDT- 2021/12/06 08:52
PHST- 2023/08/10 06:43 [medline]
PHST- 2021/12/07 06:00 [pubmed]
PHST- 2021/12/06 08:52 [entrez]
AID - S0954579421001115 [pii]
AID - 10.1017/S0954579421001115 [doi]
PST - ppublish
SO  - Dev Psychopathol. 2023 Aug;35(3):1188-1202. doi: 10.1017/S0954579421001115. Epub 
      2021 Dec 6.