PMID- 3486694
OWN - NLM
STAT- MEDLINE
DCOM- 19860707
LR  - 20190614
IS  - 0006-8993 (Print)
IS  - 0006-8993 (Linking)
VI  - 372
IP  - 2
DP  - 1986 May 7
TI  - CRF-induced seizures and behavior: interaction with amygdala kindling.
PG  - 345-51
AB  - Intracerebroventricular (i.c.v.) administration of ovine corticotropin-releasing 
      factor (CRF) in doses varying from 10 to 100 micrograms has been reported to 
      produce the late onset of seizures that resemble those observed during electrical 
      kindling of the amygdala. We assessed the effects of repeated CRF administration 
      on seizure development and on subsequent electrical kindling of the amygdala. 
      Rats were administered vehicle or CRF (100 micrograms in 10 microliter of sterile 
      water, i.c.v.) once daily for 5 consecutive days and were rated for seizures and 
      aggressive behavior. On days 1 or 2, all animals receiving CRF developed major 
      motor seizures of late onset (1-5 h post-injection), accompanied by spiking in 
      the amygdala. By day 5, however, no rats had seizures, suggesting the development 
      of tolerance. Defensive biting attacks were also observed following latencies of 
      several hours and tolerance appeared to develop to these as well. After the CRF 
      regimen, treated rats developed amygdala-kindled seizures following electrical 
      stimulation approximately twice as fast as vehicle-injected controls (P less than 
      0.03). In a second experiment, rats were electrically kindled or sham-kindled 
      prior to receiving i.c.v. CRF (100 micrograms). Kindled animals were 
      significantly less sensitive to the seizure-inducing effects of CRF (P less than 
      0.03), but were more intensely aggressive than sham-kindled animals or naive rats 
      receiving CRF for the first time.
FAU - Weiss, S R
AU  - Weiss SR
FAU - Post, R M
AU  - Post RM
FAU - Gold, P W
AU  - Gold PW
FAU - Chrousos, G
AU  - Chrousos G
FAU - Sullivan, T L
AU  - Sullivan TL
FAU - Walker, D
AU  - Walker D
FAU - Pert, A
AU  - Pert A
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - Brain Res
JT  - Brain research
JID - 0045503
RN  - 9015-71-8 (Corticotropin-Releasing Hormone)
SB  - IM
MH  - Amygdala/*physiology
MH  - Animals
MH  - Corticotropin-Releasing Hormone/*pharmacology
MH  - Electric Stimulation
MH  - Electroencephalography
MH  - Injections, Intraventricular
MH  - *Kindling, Neurologic
MH  - Male
MH  - Rats
MH  - Rats, Inbred Strains
MH  - Reaction Time/physiology
MH  - Seizures/*chemically induced
EDAT- 1986/05/07 00:00
MHDA- 1986/05/07 00:01
CRDT- 1986/05/07 00:00
PHST- 1986/05/07 00:00 [pubmed]
PHST- 1986/05/07 00:01 [medline]
PHST- 1986/05/07 00:00 [entrez]
AID - 0006-8993(86)91142-X [pii]
AID - 10.1016/0006-8993(86)91142-x [doi]
PST - ppublish
SO  - Brain Res. 1986 May 7;372(2):345-51. doi: 10.1016/0006-8993(86)91142-x.