PMID- 34866992
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220428
IS  - 1319-562X (Print)
IS  - 2213-7106 (Electronic)
IS  - 2213-7106 (Linking)
VI  - 28
IP  - 12
DP  - 2021 Dec
TI  - Multivalent cations interactions with fluoroquinolones or tetracyclines: A 
      cross-sectional study.
PG  - 6929-6932
LID - 10.1016/j.sjbs.2021.07.065 [doi]
AB  - INTRODUCTION: Oral fluoroquinolones and tetracyclines are known to interact with 
      divalent or trivalent cation-containing compounds (DTCCs) via chelation. The 
      objective of this study is to describe the prevalence of these drug-drug 
      interactions (DDIs) in an inpatient setting. METHODS: A cross-sectional study of 
      prospectively collected data were conducted at an academic tertiary care 
      hospital. We included hospitalized adults who were receiving oral 
      fluoroquinolones or tetracyclines with DTCCs in 2019. Our hospital uses 
      electronic health records for medication ordering and handwritten medication 
      administration records (MARs). The primary study outcome was the percentage of 
      simultaneous administration of fluoroquinolones or tetracyclines with DTCCs, and 
      the secondary outcome was the percentage of inappropriate separation time. 
      RESULTS: Among patients who received oral fluoroquinolones or tetracyclines, 47 
      patients (26.6%) were co-administered DTCCs and included in this study. 
      Ciprofloxacin (n = 29; 61.7%) was the most commonly interacting antibiotic, 
      followed by moxifloxacin (n = 12; 25.5%) and doxycycline (n = 6; 12.8%). The 
      interacting DTCCs included iron-containing products and calcium-containing 
      products, and half of the patients (n = 24; 51%) received DTCCs once daily. Most 
      patients (n = 35; 74.5%) were found to receive oral fluoroquinolones or 
      tetracyclines at the same time as DTCCs, while one (2.1%) received 
      inappropriately separated DTCCs. CONCLUSIONS: Despite being a very known 
      contraindicated DDI, the prevalence of simultaneous co-administration of oral 
      fluoroquinolones or tetracyclines with polyvalent cations was extremely high in a 
      hospital with handwritten MARs. Antimicrobial stewardship programs should target 
      this DDI, and future studies should evaluate the impact of different practical 
      solutions to this problem in different clinical settings.
CI  - (c) 2021 The Authors.
FAU - Eljaaly, Khalid
AU  - Eljaaly K
AD  - Faculty of Pharmacy, King Abdulaziz University, Jeddah, Saudi Arabia.
FAU - Helal, Asalah
AU  - Helal A
AD  - Faculty of Pharmacy, King Abdulaziz University, Jeddah, Saudi Arabia.
FAU - Almandeel, Tamather
AU  - Almandeel T
AD  - Faculty of Pharmacy, King Abdulaziz University, Jeddah, Saudi Arabia.
FAU - Algarni, Rawan
AU  - Algarni R
AD  - Faculty of Pharmacy, King Abdulaziz University, Jeddah, Saudi Arabia.
FAU - Alshehri, Samah
AU  - Alshehri S
AD  - Faculty of Pharmacy, King Abdulaziz University, Jeddah, Saudi Arabia.
LA  - eng
PT  - Journal Article
DEP - 20210730
PL  - Saudi Arabia
TA  - Saudi J Biol Sci
JT  - Saudi journal of biological sciences
JID - 101543796
PMC - PMC8626210
OTO - NOTNLM
OT  - Complexation
OT  - Fluoroquinolone
OT  - Interaction
OT  - Mineral
OT  - Quinolone
OT  - Tetracycline
COIS- The authors declare that they have no known competing financial interests or 
      personal relationships that could have appeared to influence the work reported in 
      this paper.
EDAT- 2021/12/07 06:00
MHDA- 2021/12/07 06:01
PMCR- 2021/07/30
CRDT- 2021/12/06 09:01
PHST- 2021/06/12 00:00 [received]
PHST- 2021/07/15 00:00 [revised]
PHST- 2021/07/25 00:00 [accepted]
PHST- 2021/12/06 09:01 [entrez]
PHST- 2021/12/07 06:00 [pubmed]
PHST- 2021/12/07 06:01 [medline]
PHST- 2021/07/30 00:00 [pmc-release]
AID - S1319-562X(21)00646-X [pii]
AID - 10.1016/j.sjbs.2021.07.065 [doi]
PST - ppublish
SO  - Saudi J Biol Sci. 2021 Dec;28(12):6929-6932. doi: 10.1016/j.sjbs.2021.07.065. 
      Epub 2021 Jul 30.