PMID- 34867274
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20211207
IS  - 1663-4365 (Print)
IS  - 1663-4365 (Electronic)
IS  - 1663-4365 (Linking)
VI  - 13
DP  - 2021
TI  - Somatosensory Cortical Electrical Stimulation After Reperfusion Attenuates 
      Ischemia/Reperfusion Injury of Rat Brain.
PG  - 741168
LID - 10.3389/fnagi.2021.741168 [doi]
LID - 741168
AB  - Objective: Ischemic stroke is an important cause of death and disability 
      worldwide. Early reperfusion by thrombolysis or thrombectomy has improved the 
      outcome of acute ischemic stroke. However, the therapeutic window for reperfusion 
      therapy is narrow, and adjuvant therapy for neuroprotection is demanded. 
      Electrical stimulation (ES) has been reported to be neuroprotective in many 
      neurological diseases. In this study, the neuroprotective effect of early 
      somatosensory cortical ES in the acute stage of ischemia/reperfusion injury was 
      evaluated. Methods: In this study, the rat model of transient middle cerebral 
      artery occlusion was used to explore the neuroprotective effect and underlying 
      mechanisms of direct primary somatosensory (S1) cortex ES with an electric 
      current of 20 Hz, 2 ms biphasic pulse, 100 muA for 30 min, starting at 30 min 
      after reperfusion. Results: These results showed that S1 cortical ES after 
      reperfusion decreased infarction volume and improved functional outcome. The 
      number of activated microglia, astrocytes, and cleaved caspase-3 positive neurons 
      after ischemia/reperfusion injury were reduced, demonstrating that S1 cortical ES 
      alleviates inflammation and apoptosis. Brain-derived neurotrophic factor (BDNF) 
      and phosphoinositide 3-kinase (PI3K)/Akt/mammalian target of rapamycin (mTOR) 
      signaling pathway were upregulated in the penumbra area, suggesting that 
      BDNF/TrkB signals and their downstream PI3K/Akt signaling pathway play roles in 
      ES-related neuroprotection. Conclusion: This study demonstrates that 
      somatosensory cortical ES soon after reperfusion can attenuate 
      ischemia/reperfusion injury and is a promising adjuvant therapy for thrombolytic 
      treatment after acute ischemic stroke. Advanced techniques and devices for 
      high-definition transcranial direct current stimulation still deserve further 
      development in this regard.
CI  - Copyright (c) 2021 Wang, Wei, Ho, Wu, Chu and Tsai.
FAU - Wang, Liang-Chao
AU  - Wang LC
AD  - Division of Neurosurgery, Department of Surgery, National Cheng Kung University 
      Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
AD  - Institute of Clinical Medicine, College of Medicine, National Cheng Kung 
      University, Tainan, Taiwan.
FAU - Wei, Wei-Yen
AU  - Wei WY
AD  - Institute of Clinical Medicine, College of Medicine, National Cheng Kung 
      University, Tainan, Taiwan.
FAU - Ho, Pei-Chuan
AU  - Ho PC
AD  - Institute of Clinical Medicine, College of Medicine, National Cheng Kung 
      University, Tainan, Taiwan.
FAU - Wu, Pei-Yi
AU  - Wu PY
AD  - Institute of Clinical Medicine, College of Medicine, National Cheng Kung 
      University, Tainan, Taiwan.
FAU - Chu, Yuan-Ping
AU  - Chu YP
AD  - Institute of Clinical Medicine, College of Medicine, National Cheng Kung 
      University, Tainan, Taiwan.
FAU - Tsai, Kuen-Jer
AU  - Tsai KJ
AD  - Institute of Clinical Medicine, College of Medicine, National Cheng Kung 
      University, Tainan, Taiwan.
AD  - Research Center of Clinical Medicine, National Cheng Kung University Hospital, 
      College of Medicine, National Cheng Kung University, Tainan, Taiwan.
AD  - Center of Cell Therapy, National Cheng Kung University Hospital, College of 
      Medicine, National Cheng Kung University, Tainan, Taiwan.
LA  - eng
PT  - Journal Article
DEP - 20211112
PL  - Switzerland
TA  - Front Aging Neurosci
JT  - Frontiers in aging neuroscience
JID - 101525824
PMC - PMC8632773
OTO - NOTNLM
OT  - BDNF
OT  - PI3K - PKB/Akt signaling pathway
OT  - cortical electrical stimulation
OT  - ischemic stroke
OT  - neuromodulation
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2021/12/07 06:00
MHDA- 2021/12/07 06:01
PMCR- 2021/01/01
CRDT- 2021/12/06 09:04
PHST- 2021/07/14 00:00 [received]
PHST- 2021/10/11 00:00 [accepted]
PHST- 2021/12/06 09:04 [entrez]
PHST- 2021/12/07 06:00 [pubmed]
PHST- 2021/12/07 06:01 [medline]
PHST- 2021/01/01 00:00 [pmc-release]
AID - 10.3389/fnagi.2021.741168 [doi]
PST - epublish
SO  - Front Aging Neurosci. 2021 Nov 12;13:741168. doi: 10.3389/fnagi.2021.741168. 
      eCollection 2021.