PMID- 34867283 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20211207 IS - 1663-4365 (Print) IS - 1663-4365 (Electronic) IS - 1663-4365 (Linking) VI - 13 DP - 2021 TI - Lateralized Contributions of Medial Prefrontal Cortex Network to Episodic Memory Deficits in Subjects With Amnestic Mild Cognitive Impairment. PG - 756241 LID - 10.3389/fnagi.2021.756241 [doi] LID - 756241 AB - Both episodic memory and executive function are impaired in amnestic mild cognitive impairment (aMCI) subjects, but it is unclear if these impairments are independent or interactive. The present study aimed to explore the relationship between episodic memory deficits and executive function deficits, and the underlying functional mechanisms in aMCI subjects. Thirty-one aMCI subjects and 27 healthy subjects underwent neuropsychological tests and multimodal magnetic resonance imaging (MRI) scans. Hippocampal networks and medial prefrontal cortex (MPFC) networks were identified based on resting-sate functional MRI (fMRI) data. AMCI subjects displayed lower episodic memory scores and executive function scores than control subjects, and the episodic memory scores were positively correlated with the executive function scores in aMCI subjects. Brain network analyses showed an interaction between the hippocampal networks and the MPFC networks, and the interaction was significantly associated with the episodic memory scores and the executive function scores. Notably, aMCI subjects displayed higher functional connectivity (FC) of the right hippocampal network with the right prefrontal cortex than did control subjects, but this difference disappeared when controlling for the MPFC networks. Furthermore, the effects of the MPFC networks on the hippocampal networks were significantly associated with the episodic memory scores in aMCI subjects. The present findings suggested that the episodic memory deficits in aMCI subjects could be partially underpinned by the modulation of the MPFC networks on the hippocampal networks. CI - Copyright (c) 2021 Ye, Chen, Liu, Qin, Luo, Li, Xu, Zhao and Bai. FAU - Ye, Qing AU - Ye Q AD - Department of Neurology, Nanjing Drum Tower Hospital, Nanjing University Medical School, Nanjing, China. AD - The State Key Laboratory of Pharmaceutical Biotechnology, Institute of Brain Science, Nanjing University, Nanjing, China. AD - Jiangsu Province Stroke Center for Diagnosis and Therapy, Nanjing, China. AD - Nanjing Neuropsychiatry Clinic Medical Center, Nanjing, China. FAU - Chen, Haifeng AU - Chen H AD - Department of Neurology, Nanjing Drum Tower Hospital, Nanjing University Medical School, Nanjing, China. AD - The State Key Laboratory of Pharmaceutical Biotechnology, Institute of Brain Science, Nanjing University, Nanjing, China. AD - Jiangsu Province Stroke Center for Diagnosis and Therapy, Nanjing, China. AD - Nanjing Neuropsychiatry Clinic Medical Center, Nanjing, China. FAU - Liu, Renyuan AU - Liu R AD - Department of Neurology, Nanjing Drum Tower Hospital, Nanjing University Medical School, Nanjing, China. AD - Department of Radiology, Nanjing Drum Tower Hospital, Nanjing University Medical School, Nanjing, China. FAU - Qin, Ruomeng AU - Qin R AD - Department of Neurology, Nanjing Drum Tower Hospital, Nanjing University Medical School, Nanjing, China. AD - The State Key Laboratory of Pharmaceutical Biotechnology, Institute of Brain Science, Nanjing University, Nanjing, China. AD - Jiangsu Province Stroke Center for Diagnosis and Therapy, Nanjing, China. AD - Nanjing Neuropsychiatry Clinic Medical Center, Nanjing, China. FAU - Luo, Caimei AU - Luo C AD - Department of Neurology, Nanjing Drum Tower Hospital, Nanjing University Medical School, Nanjing, China. AD - The State Key Laboratory of Pharmaceutical Biotechnology, Institute of Brain Science, Nanjing University, Nanjing, China. AD - Jiangsu Province Stroke Center for Diagnosis and Therapy, Nanjing, China. AD - Nanjing Neuropsychiatry Clinic Medical Center, Nanjing, China. FAU - Li, Mengchun AU - Li M AD - Department of Neurology, Nanjing Drum Tower Hospital, Nanjing University Medical School, Nanjing, China. AD - The State Key Laboratory of Pharmaceutical Biotechnology, Institute of Brain Science, Nanjing University, Nanjing, China. AD - Jiangsu Province Stroke Center for Diagnosis and Therapy, Nanjing, China. AD - Nanjing Neuropsychiatry Clinic Medical Center, Nanjing, China. FAU - Xu, Yun AU - Xu Y AD - Department of Neurology, Nanjing Drum Tower Hospital, Nanjing University Medical School, Nanjing, China. AD - The State Key Laboratory of Pharmaceutical Biotechnology, Institute of Brain Science, Nanjing University, Nanjing, China. AD - Jiangsu Province Stroke Center for Diagnosis and Therapy, Nanjing, China. AD - Nanjing Neuropsychiatry Clinic Medical Center, Nanjing, China. FAU - Zhao, Hui AU - Zhao H AD - Department of Neurology, Nanjing Drum Tower Hospital, Nanjing University Medical School, Nanjing, China. AD - The State Key Laboratory of Pharmaceutical Biotechnology, Institute of Brain Science, Nanjing University, Nanjing, China. AD - Jiangsu Province Stroke Center for Diagnosis and Therapy, Nanjing, China. AD - Nanjing Neuropsychiatry Clinic Medical Center, Nanjing, China. FAU - Bai, Feng AU - Bai F AD - Department of Neurology, Nanjing Drum Tower Hospital, Nanjing University Medical School, Nanjing, China. AD - The State Key Laboratory of Pharmaceutical Biotechnology, Institute of Brain Science, Nanjing University, Nanjing, China. AD - Jiangsu Province Stroke Center for Diagnosis and Therapy, Nanjing, China. AD - Nanjing Neuropsychiatry Clinic Medical Center, Nanjing, China. LA - eng PT - Journal Article DEP - 20211117 PL - Switzerland TA - Front Aging Neurosci JT - Frontiers in aging neuroscience JID - 101525824 PMC - PMC8635729 OTO - NOTNLM OT - episodic memory OT - executive function OT - functional magnetic resonance imaging OT - hippocampal network OT - medial prefrontal cortex network OT - mild cognitive impairment COIS- The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2021/12/07 06:00 MHDA- 2021/12/07 06:01 PMCR- 2021/01/01 CRDT- 2021/12/06 09:04 PHST- 2021/08/10 00:00 [received] PHST- 2021/10/27 00:00 [accepted] PHST- 2021/12/06 09:04 [entrez] PHST- 2021/12/07 06:00 [pubmed] PHST- 2021/12/07 06:01 [medline] PHST- 2021/01/01 00:00 [pmc-release] AID - 10.3389/fnagi.2021.756241 [doi] PST - epublish SO - Front Aging Neurosci. 2021 Nov 17;13:756241. doi: 10.3389/fnagi.2021.756241. eCollection 2021.