PMID- 34867297
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20211207
IS  - 1663-4365 (Print)
IS  - 1663-4365 (Electronic)
IS  - 1663-4365 (Linking)
VI  - 13
DP  - 2021
TI  - Region-Specific Neurovascular Decoupling Associated With Cognitive Decline in 
      Parkinson's Disease.
PG  - 770528
LID - 10.3389/fnagi.2021.770528 [doi]
LID - 770528
AB  - Background: Cognitive deficits are prominent non-motor symptoms in Parkinson's 
      disease (PD) and have been shown to involve the neurovascular unit (NVU). 
      However, there is a lack of sufficient neuroimaging research on the associated 
      modulating mechanisms. The objective of this study was to identify the 
      contribution of neurovascular decoupling to the pathogenesis of cognitive decline 
      in PD. Methods: Regional homogeneity (ReHo), a measure of neuronal activity, and 
      cerebral blood flow (CBF), a measure of vascular responses, were obtained from 
      patients with PD with mild cognitive impairment (MCI) and normal cognition (NC) 
      as well as matched healthy controls (HCs). Imaging metrics of neurovascular 
      coupling (global and regional CBF-ReHo correlation coefficients and CBF-ReHo 
      ratios) were compared among the groups. Results: Neurovascular coupling was 
      impaired in patients with PD-MCI with a decreased global CBF-ReHo correlation 
      coefficient relative to HC subjects (P < 0.05). Regional dysregulation was 
      specific to the PD-MCI group and localized to the right middle frontal gyrus, 
      right middle cingulate cortex, right middle occipital gyrus, right inferior 
      parietal gyrus, right supramarginal gyrus, and right angular gyrus (P < 0.05). 
      Compared with HC subjects, patients with PD-MCI showed higher CBF-ReHo ratios in 
      the bilateral lingual gyri (LG), bilateral putamen, and left postcentral gyrus 
      and lower CBF-ReHo ratios in the right superior temporal gyrus, bilateral middle 
      temporal gyri, bilateral parahippocampal gyri, and right inferior frontal gyrus. 
      Relative to the HC and PD-NC groups, the PD-MCI group showed an increased 
      CBF-ReHo ratio in the left LG, which was correlated with poor visual-spatial 
      performance (r = -0.36 and P = 0.014). Conclusion: The involvement of 
      neurovascular decoupling in cognitive impairment in PD is regionally specific and 
      most prominent in the visual-spatial cortices, which could potentially provide a 
      complementary understanding of the pathophysiological mechanisms underlying 
      cognitive deficits in PD.
CI  - Copyright (c) 2021 Shang, Zhang, Feng, Wu, Dou, Chen and Yin.
FAU - Shang, Song'an
AU  - Shang S
AD  - Department of Radiology, Nanjing First Hospital, Nanjing Medical University, 
      Nanjing, China.
FAU - Zhang, Hongying
AU  - Zhang H
AD  - Department of Radiology, Clinical Medical College, Yangzhou University, Yangzhou, 
      China.
FAU - Feng, Yuan
AU  - Feng Y
AD  - Department of Radiology, Nanjing First Hospital, Nanjing Medical University, 
      Nanjing, China.
FAU - Wu, Jingtao
AU  - Wu J
AD  - Department of Radiology, Clinical Medical College, Yangzhou University, Yangzhou, 
      China.
FAU - Dou, Weiqiang
AU  - Dou W
AD  - MR Research China, GE Healthcare, Beijing, China.
FAU - Chen, Yu-Chen
AU  - Chen YC
AD  - Department of Radiology, Nanjing First Hospital, Nanjing Medical University, 
      Nanjing, China.
FAU - Yin, Xindao
AU  - Yin X
AD  - Department of Radiology, Nanjing First Hospital, Nanjing Medical University, 
      Nanjing, China.
LA  - eng
PT  - Journal Article
DEP - 20211115
PL  - Switzerland
TA  - Front Aging Neurosci
JT  - Frontiers in aging neuroscience
JID - 101525824
PMC - PMC8636132
OTO - NOTNLM
OT  - Parkinson's disease
OT  - cerebral blood flow
OT  - cognitive impairment
OT  - magnetic resonance imaging
OT  - neurovascular coupling
OT  - regional homogeneity
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2021/12/07 06:00
MHDA- 2021/12/07 06:01
PMCR- 2021/01/01
CRDT- 2021/12/06 09:04
PHST- 2021/09/04 00:00 [received]
PHST- 2021/10/11 00:00 [accepted]
PHST- 2021/12/06 09:04 [entrez]
PHST- 2021/12/07 06:00 [pubmed]
PHST- 2021/12/07 06:01 [medline]
PHST- 2021/01/01 00:00 [pmc-release]
AID - 10.3389/fnagi.2021.770528 [doi]
PST - epublish
SO  - Front Aging Neurosci. 2021 Nov 15;13:770528. doi: 10.3389/fnagi.2021.770528. 
      eCollection 2021.