PMID- 34867331
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20211207
IS  - 1663-9812 (Print)
IS  - 1663-9812 (Electronic)
IS  - 1663-9812 (Linking)
VI  - 12
DP  - 2021
TI  - Low Molecular Weight Heparin Improves the Inflammatory State of Acute Sinusitis 
      Rats Through Inhibiting the TLR4-MyD88-NF-kappaB Signaling Pathway.
PG  - 726630
LID - 10.3389/fphar.2021.726630 [doi]
LID - 726630
AB  - Introduction: Low molecular weight heparin (LMWH), a natural sulfated 
      glycosaminoglycan with an affinity for proangiogenic factors, is produced by 
      chemical or enzymatic depolymerization of unfractionated heparin (UFH). Known for 
      its anticoagulant effects, LMWH has recently been reported to have a strong 
      anti-inflammatory effect on colitis, myocarditis, and airway inflammation. 
      However, as a newly-developed drug, its anti-inflammatory mechanism in upper 
      respiratory tract inflammation has not been well-studied. Methods: SD rats were 
      randomly divided into control and experimental groups. The experimental group was 
      established by building an acute nasal sinusitis model with expansion sponges 
      mixed with Streptococcus pneumoniae. Then the experimental group rats were 
      subcutaneously injected with different concentrations of LMWH. After seven 
      consecutive days of injection, some rats were sacrificed, and blood and nasal 
      mucosa samples were taken to determine their inflammation status. The remaining 
      acute sinusitis rats were randomly selected for a week of nasal irrigation with 
      normal saline or saline mixed with different concentrations of LMWH. One week 
      later, rats were sacrificed, and samples of blood and nasal mucosa were taken to 
      determine the inflammation status. Results: Rat nasal mucosa in the model group 
      had obvious inflammation. The degree of nasal mucosa inflammation damage in the 
      experimental group was lower than in the experimental control group, proving that 
      LMWH has a protective effect on the nasal mucosa and that the effect correlates 
      with dosage. Irrigation of the nose with saline mixed with LMWH can improve the 
      anti-inflammatory effect. Protein related to the TLR4-MyD88-NF-kappaB signaling 
      pathway was activated in the acute sinusitis rat model, and LMWH can 
      significantly inhibit its expression. Conclusion: This is the first report of the 
      anti-inflammatory effect of LMWH in acute upper respiratory tract inflammation, 
      together with an explanation of its anti-inflammatory mechanism. The findings 
      contribute a theoretical basis for its potential anti-tumor effect.
CI  - Copyright (c) 2021 Wu, He, Jiao, Liang, Chen, Liu, Zhang and He.
FAU - Wu, Tong
AU  - Wu T
AD  - Department of Otolaryngology-Head Neck Surgery, Third Xiangya Hospital, Central 
      South University, Changsha, China.
AD  - Department of Head and Neck Surgery, State Key Laboratory of Oncology in South 
      China, Collaborative Innovation Center of Cancer Medicine, Sun Yat-sen University 
      Cancer Center, Guangzhou, China.
FAU - He, Sihan
AU  - He S
AD  - Institute of Molecular Precision Medicine, Xiangya Hospital and Center for 
      Medical Genetics, Central South University, Changsha, China.
FAU - Jiao, Zan
AU  - Jiao Z
AD  - Department of Head and Neck Surgery, State Key Laboratory of Oncology in South 
      China, Collaborative Innovation Center of Cancer Medicine, Sun Yat-sen University 
      Cancer Center, Guangzhou, China.
FAU - Liang, Xiang
AU  - Liang X
AD  - Department of Otolaryngology-Head Neck Surgery, Third Xiangya Hospital, Central 
      South University, Changsha, China.
FAU - Chen, Yu
AU  - Chen Y
AD  - Department of Otolaryngology-Head Neck Surgery, Third Xiangya Hospital, Central 
      South University, Changsha, China.
FAU - Liu, Huow
AU  - Liu H
AD  - Department of Otolaryngology-Head Neck Surgery, Third Xiangya Hospital, Central 
      South University, Changsha, China.
FAU - Zhang, Yongq
AU  - Zhang Y
AD  - Department of Otolaryngology-Head Neck Surgery, Third Xiangya Hospital, Central 
      South University, Changsha, China.
FAU - He, GuangX
AU  - He G
AD  - Department of Otolaryngology-Head Neck Surgery, Third Xiangya Hospital, Central 
      South University, Changsha, China.
LA  - eng
PT  - Journal Article
DEP - 20211117
PL  - Switzerland
TA  - Front Pharmacol
JT  - Frontiers in pharmacology
JID - 101548923
PMC - PMC8635784
OTO - NOTNLM
OT  - acute sinusitis
OT  - anti-inflammation
OT  - low molecular weight heparin
OT  - natural sulfated glycosaminoglycan
OT  - nuclear factor kappa-B
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2021/12/07 06:00
MHDA- 2021/12/07 06:01
PMCR- 2021/11/17
CRDT- 2021/12/06 09:04
PHST- 2021/06/17 00:00 [received]
PHST- 2021/11/02 00:00 [accepted]
PHST- 2021/12/06 09:04 [entrez]
PHST- 2021/12/07 06:00 [pubmed]
PHST- 2021/12/07 06:01 [medline]
PHST- 2021/11/17 00:00 [pmc-release]
AID - 726630 [pii]
AID - 10.3389/fphar.2021.726630 [doi]
PST - epublish
SO  - Front Pharmacol. 2021 Nov 17;12:726630. doi: 10.3389/fphar.2021.726630. 
      eCollection 2021.