PMID- 34867389
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20211207
IS  - 1663-9812 (Print)
IS  - 1663-9812 (Electronic)
IS  - 1663-9812 (Linking)
VI  - 12
DP  - 2021
TI  - Long Non-Coding RNA-Mediated Competing Endogenous RNA Networks in Ischemic 
      Stroke: Molecular Mechanisms, Therapeutic Implications, and Challenges.
PG  - 765075
LID - 10.3389/fphar.2021.765075 [doi]
LID - 765075
AB  - Ischemic stroke (IS) is a disease that is characterized by high mortality and 
      disability. Recent studies have shown that LncRNA-mediated competing endogenous 
      RNA (ceRNA) networks play roles in the occurrence and development of cerebral I/R 
      injury by regulating different signaling pathways. However, no systematic 
      analysis of ceRNA mechanisms in IS has been reported. In this review, we discuss 
      molecular mechanisms of LncRNA-mediated ceRNA networks under I/R injury. The 
      expression levels of LncRNAs, microRNAs (miRNAs), and messenger RNAs (mRNAs) and 
      their effects in four major cell types of the neurovascular unit (NVU) are also 
      involved. We further summarize studies of LncRNAs as biomarkers and therapeutic 
      targets. Finally, we analyze the advantages and limitations of using LncRNAs as 
      therapeutics for IS.
CI  - Copyright (c) 2021 Zhang, Zhu, Li, Sun and Sun.
FAU - Zhang, Shuxia
AU  - Zhang S
AD  - Beijing Key Laboratory of Innovative Drug Discovery of Traditional Chinese 
      Medicine (Natural Medicine) and Translational Medicine, Institute of Medicinal 
      Plant Development, Peking Union Medical College and Chinese Academy of Medical 
      Sciences, Beijing, China.
AD  - Key Laboratory of Bioactive Substances and Resources Utilization of Chinese 
      Herbal Medicine, Ministry of Education, Institute of Medicinal Plant Development, 
      Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 
      China.
AD  - Key Laboratory of Efficacy Evaluation of Chinese Medicine Against Glycolipid 
      Metabolic Disorders, State Administration of Traditional Chinese Medicine, 
      Institute of Medicinal Plant Development, Peking Union Medical College and 
      Chinese Academy of Medical Sciences, Beijing, China.
AD  - Zhongguancun Open Laboratory of the Research and Development of Natural Medicine 
      and Health Products, Institute of Medicinal Plant Development, Chinese Academy of 
      Medical Sciences and Peking Union Medical College, Beijing, China.
AD  - Key Laboratory of New Drug Discovery Based on Classic Chinese Medicine 
      Prescription, Chinese Academy of Medical Sciences, Beijing, China.
FAU - Zhu, Ting
AU  - Zhu T
AD  - Institute of Neuroregeneration and Neurorehabilitation, Qingdao University, 
      Qingdao, China.
FAU - Li, Qiaoyu
AU  - Li Q
AD  - Beijing Key Laboratory of Innovative Drug Discovery of Traditional Chinese 
      Medicine (Natural Medicine) and Translational Medicine, Institute of Medicinal 
      Plant Development, Peking Union Medical College and Chinese Academy of Medical 
      Sciences, Beijing, China.
AD  - Key Laboratory of Bioactive Substances and Resources Utilization of Chinese 
      Herbal Medicine, Ministry of Education, Institute of Medicinal Plant Development, 
      Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 
      China.
AD  - Key Laboratory of Efficacy Evaluation of Chinese Medicine Against Glycolipid 
      Metabolic Disorders, State Administration of Traditional Chinese Medicine, 
      Institute of Medicinal Plant Development, Peking Union Medical College and 
      Chinese Academy of Medical Sciences, Beijing, China.
AD  - Zhongguancun Open Laboratory of the Research and Development of Natural Medicine 
      and Health Products, Institute of Medicinal Plant Development, Chinese Academy of 
      Medical Sciences and Peking Union Medical College, Beijing, China.
AD  - Key Laboratory of New Drug Discovery Based on Classic Chinese Medicine 
      Prescription, Chinese Academy of Medical Sciences, Beijing, China.
FAU - Sun, Guibo
AU  - Sun G
AD  - Beijing Key Laboratory of Innovative Drug Discovery of Traditional Chinese 
      Medicine (Natural Medicine) and Translational Medicine, Institute of Medicinal 
      Plant Development, Peking Union Medical College and Chinese Academy of Medical 
      Sciences, Beijing, China.
AD  - Key Laboratory of Bioactive Substances and Resources Utilization of Chinese 
      Herbal Medicine, Ministry of Education, Institute of Medicinal Plant Development, 
      Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 
      China.
AD  - Key Laboratory of Efficacy Evaluation of Chinese Medicine Against Glycolipid 
      Metabolic Disorders, State Administration of Traditional Chinese Medicine, 
      Institute of Medicinal Plant Development, Peking Union Medical College and 
      Chinese Academy of Medical Sciences, Beijing, China.
AD  - Zhongguancun Open Laboratory of the Research and Development of Natural Medicine 
      and Health Products, Institute of Medicinal Plant Development, Chinese Academy of 
      Medical Sciences and Peking Union Medical College, Beijing, China.
AD  - Key Laboratory of New Drug Discovery Based on Classic Chinese Medicine 
      Prescription, Chinese Academy of Medical Sciences, Beijing, China.
FAU - Sun, Xiaobo
AU  - Sun X
AD  - Beijing Key Laboratory of Innovative Drug Discovery of Traditional Chinese 
      Medicine (Natural Medicine) and Translational Medicine, Institute of Medicinal 
      Plant Development, Peking Union Medical College and Chinese Academy of Medical 
      Sciences, Beijing, China.
AD  - Key Laboratory of Bioactive Substances and Resources Utilization of Chinese 
      Herbal Medicine, Ministry of Education, Institute of Medicinal Plant Development, 
      Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 
      China.
AD  - Key Laboratory of Efficacy Evaluation of Chinese Medicine Against Glycolipid 
      Metabolic Disorders, State Administration of Traditional Chinese Medicine, 
      Institute of Medicinal Plant Development, Peking Union Medical College and 
      Chinese Academy of Medical Sciences, Beijing, China.
AD  - Zhongguancun Open Laboratory of the Research and Development of Natural Medicine 
      and Health Products, Institute of Medicinal Plant Development, Chinese Academy of 
      Medical Sciences and Peking Union Medical College, Beijing, China.
AD  - Key Laboratory of New Drug Discovery Based on Classic Chinese Medicine 
      Prescription, Chinese Academy of Medical Sciences, Beijing, China.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20211117
PL  - Switzerland
TA  - Front Pharmacol
JT  - Frontiers in pharmacology
JID - 101548923
PMC - PMC8635732
OTO - NOTNLM
OT  - competing endogenous RNA network
OT  - ischemia-reperfusion injury
OT  - ischemic stroke
OT  - long non-coding RNA
OT  - therapeutic target
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest. The Reviewer M.P declared a shared affiliation with one of 
      the Authors T.Z to the Handling Editor at the time of review.
EDAT- 2021/12/07 06:00
MHDA- 2021/12/07 06:01
PMCR- 2021/11/17
CRDT- 2021/12/06 09:04
PHST- 2021/08/26 00:00 [received]
PHST- 2021/10/20 00:00 [accepted]
PHST- 2021/12/06 09:04 [entrez]
PHST- 2021/12/07 06:00 [pubmed]
PHST- 2021/12/07 06:01 [medline]
PHST- 2021/11/17 00:00 [pmc-release]
AID - 765075 [pii]
AID - 10.3389/fphar.2021.765075 [doi]
PST - epublish
SO  - Front Pharmacol. 2021 Nov 17;12:765075. doi: 10.3389/fphar.2021.765075. 
      eCollection 2021.