PMID- 34868462
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20211207
IS  - 1944-8171 (Print)
IS  - 1944-8171 (Electronic)
IS  - 1944-8171 (Linking)
VI  - 13
IP  - 5
DP  - 2021
TI  - Comparison of the triglyceride-waist circumference and the C-reactive 
      protein-waist circumference indices in nascent metabolic syndrome.
PG  - 126-131
AB  - The Hypertriglyceridemia waist (HTGW) appears to be a valid measure of visceral 
      adiposity, metabolic syndrome (MetS), type 2 diabetes mellitus (T2DM) and 
      atherosclerotic cardiovascular disease (ASCVD). Since the cut points differ for 
      different race groups recent studies have instead used the simplified product of 
      triglycerides and waist circumference (TG.WC). In our patients with nascent MetS 
      (without the confounding of T2DM, ASCVD, smoking and macro-inflammation) we found 
      that only 41% had an increased HTGW. Since MetS is a pro-inflammatory disorder we 
      compared the product of CRP to WC (CRP.WC) to TG.WC in our patients with nascent 
      MetS as biomarkers. Patients with MetS (n=58) and matched controls (n=44) were 
      recruited. Fasting blood samples were obtained for routine laboratories including 
      the lipid profile, insulin, and adipokines. Both the TG.WC and CRP.WC indices 
      were significantly increased in MetS and both increased with increasing severity 
      of MetS. Whilst both correlated with cardio-metabolic features and insulin 
      resistance, only the CRP.WC correlated significantly with adiponectin, an 
      adipokine largely deriving from visceral adipose tissue. The TG.WC correlated 
      with LDL-cholesterol which was not increased in this group. Receiver Operating 
      Characteristic (ROC) curve analysis showed that both ratios showed good 
      discrimination for MetS with no significant differences between ratios. Thus both 
      the TG.WC and CRP.WC indices are significantly increased in patients with nascent 
      MetS and appear to be valid biomarkers of MetS.
CI  - IJPPP Copyright (c) 2021.
FAU - Jialal, Ishwarlal
AU  - Jialal I
AD  - Veterans Affairs Medical Center Mather 95655, CA, USA.
FAU - Adams-Huet, Beverley
AU  - Adams-Huet B
AD  - UT Southwestern Medical Center Dallas 75390, TX, USA.
LA  - eng
PT  - Journal Article
DEP - 20211015
PL  - United States
TA  - Int J Physiol Pathophysiol Pharmacol
JT  - International journal of physiology, pathophysiology and pharmacology
JID - 101521074
PMC - PMC8611242
OTO - NOTNLM
OT  - C-reactive protein
OT  - Metabolic syndrome
OT  - adiposity
OT  - inflammation
OT  - triglycerides
OT  - visceral fat
OT  - waist circumference
COIS- None.
EDAT- 2021/12/07 06:00
MHDA- 2021/12/07 06:01
PMCR- 2021/10/15
CRDT- 2021/12/06 09:12
PHST- 2021/07/16 00:00 [received]
PHST- 2021/08/23 00:00 [accepted]
PHST- 2021/12/06 09:12 [entrez]
PHST- 2021/12/07 06:00 [pubmed]
PHST- 2021/12/07 06:01 [medline]
PHST- 2021/10/15 00:00 [pmc-release]
PST - epublish
SO  - Int J Physiol Pathophysiol Pharmacol. 2021 Oct 15;13(5):126-131. eCollection 
      2021.