PMID- 34868769
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20211207
IS  - 2168-8184 (Print)
IS  - 2168-8184 (Electronic)
IS  - 2168-8184 (Linking)
VI  - 13
IP  - 10
DP  - 2021 Oct
TI  - Adult Nodal Burkitt Lymphoma Forming Nodular Architectures.
PG  - e19130
LID - 10.7759/cureus.19130 [doi]
LID - e19130
AB  - In this report, we discuss a case of nodal Burkitt lymphoma seen in a 60-year-old 
      Japanese male patient. Microscopic features of the biopsied 30 mm-sized cervical 
      lymph node revealed nodular architectures with starry sky appearance surrounded 
      by small mantle zone B-lymphocytes. Immunohistochemical and molecular studies 
      demonstrated typical features of sporadic Burkitt lymphoma: the atypical cells 
      were positive for CD20, CD79a, CD10, CD23, HLA-DR, bcl-6, PAX5, c-myc, and 
      cytoplasmic IgM, but negative for CD3, CD5, CD15, CD30, CD34, TdT, bcl-2, and 
      MUM1. The mantle zone B-cells were clearly positive for bcl-2 and IgD. In 
      situhybridization (ISH) analysis for immunoglobulin light chains showed 
      kappa-type monoclonality. A few nuclei were labeled for Epstein-Barr 
      virus-encoded small nuclear RNA (EBER). Ki-67 labeling index was nearly 100%. 
      Within the nodule, CD21, CD23, and CD35-positive follicular dendritic cells were 
      scattered with a small number of CD3/CD5-positive small T-lymphocytes, indicating 
      that the nodular architecture represented follicular colonization of Burkitt 
      lymphoma cells. Karyotypic analysis revealed t(8;14)(q24;q32), and IGH-MYC 
      fluorescence in situ hybridization (FISH) demonstrated IGH-MYC fusion signals. 
      The presentation of follicular colonization was quite unique in Burkitt lymphoma 
      in the present case. Differential diagnosis is also discussed.
CI  - Copyright (c) 2021, Tsutsumi et al.
FAU - Tsutsumi, Yutaka
AU  - Tsutsumi Y
AD  - Diagnostic Pathology Clinic, Pathos Tsutsumi, Inazawa, JPN.
AD  - Department of Diagnostic Pathology, Shimada City General Medical Center, Shimada, 
      JPN.
FAU - Yanagita, Soshi
AU  - Yanagita S
AD  - Department of Hematology, Shimada City General Medical Center, Shimada, JPN.
FAU - Ohshima, Kouichi
AU  - Ohshima K
AD  - Department of Pathology, Kurume University School of Medicine, Kurume, JPN.
FAU - Tachibana, Mitsuhiro
AU  - Tachibana M
AD  - Department of Diagnostic Pathology, Shimada City General Medical Center, Shimada, 
      JPN.
LA  - eng
PT  - Case Reports
DEP - 20211029
PL  - United States
TA  - Cureus
JT  - Cureus
JID - 101596737
PMC - PMC8627692
OTO - NOTNLM
OT  - follicular colonization
OT  - immunohistochemistry
OT  - molecular analysis
OT  - nodal burkitt lymphoma
OT  - nodular architectures
COIS- The authors have declared that no competing interests exist.
EDAT- 2021/12/07 06:00
MHDA- 2021/12/07 06:01
PMCR- 2021/10/29
CRDT- 2021/12/06 09:16
PHST- 2021/10/29 00:00 [accepted]
PHST- 2021/12/06 09:16 [entrez]
PHST- 2021/12/07 06:00 [pubmed]
PHST- 2021/12/07 06:01 [medline]
PHST- 2021/10/29 00:00 [pmc-release]
AID - 10.7759/cureus.19130 [doi]
PST - epublish
SO  - Cureus. 2021 Oct 29;13(10):e19130. doi: 10.7759/cureus.19130. eCollection 2021 
      Oct.