PMID- 34868804
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220902
IS  - 2192-8606 (Print)
IS  - 2192-8614 (Electronic)
VI  - 10
IP  - 12
DP  - 2021 Sep
TI  - Brief exposure of skin to near-infrared laser augments early vaccine responses.
PG  - 3187-3197
LID - 10.1515/nanoph-2021-0133 [doi]
AB  - Rapid establishment of herd immunity with vaccination is effective to combat 
      emerging infectious diseases. Although the incorporation of adjuvant and 
      intradermal (ID) injection could augment early responses to the vaccine, the 
      current chemical or biological adjuvants are inappropriate for this purpose with 
      their side effects and high reactogenicity in the skin. Recently, a near-infrared 
      (NIR) laser has been shown to augment the immune response to ID vaccination and 
      could be alternatively used for mass vaccination programs. Here, we determined 
      the effect of NIR laser as well as licensed chemical adjuvants on the 
      immunogenicity 1, 2, and 4 weeks after ID influenza vaccination in mice. The NIR 
      laser adjuvant augmented early antibody responses, while the widely used alum 
      adjuvant induced significantly delayed responses. In addition, the oil-in-water 
      and alum adjuvants, but not the NIR laser, elicited escalated T(H)2 responses 
      with allergenic immunoglobulin E (IgE) responses. The effect of the NIR laser was 
      significantly suppressed in the basic leucine zipper transcription factor 
      ATF-like 3 (Batf3) knockout mice, suggesting a critical role of the cluster of 
      differentiation 103(+) (CD103)(+) dendritic cells. The current preliminary study 
      suggests that NIR laser adjuvant is an alternative strategy to chemical and 
      biological agents to timely combat emerging infectious diseases. Moreover, its 
      immunomodulatory property could be used to enhance the efficacy of immunotherapy 
      for allergy and cancer.
FAU - Yokomizo, Shinya
AU  - Yokomizo S
AD  - Gordon Center for Medical Imaging, Department of Radiology, Massachusetts General 
      Hospital, 149 13th Street, Charlestown 02129, MA, USA.
FAU - Katagiri, Wataru
AU  - Katagiri W
AD  - Gordon Center for Medical Imaging, Department of Radiology, Massachusetts General 
      Hospital, 149 13th Street, Charlestown 02129, MA, USA.
FAU - Maki, Yohei
AU  - Maki Y
AD  - Division of Infectious Diseases and Respiratory Medicine, Department of Medicine, 
      National Defense Medical College, 3-2 Namiki, Tokorozawa, Saitama 359-8513, 
      Japan.
FAU - Sano, Tomoya
AU  - Sano T
AD  - Division of Infectious Diseases and Respiratory Medicine, Department of Medicine, 
      National Defense Medical College, 3-2 Namiki, Tokorozawa, Saitama 359-8513, 
      Japan.
FAU - Inoue, Kazumasa
AU  - Inoue K
AD  - Department of Radiological Sciences, Tokyo Metropolitan University, 7-2-10 
      Higashi-Ogu, Arakawa 116-8551, Tokyo, Japan.
FAU - Fukushi, Masahiro
AU  - Fukushi M
AD  - Department of Radiological Sciences, Tokyo Metropolitan University, 7-2-10 
      Higashi-Ogu, Arakawa 116-8551, Tokyo, Japan.
FAU - Atochin, Dmitriy N
AU  - Atochin DN
AD  - Cardiovascular Research Center, Department of Medicine, Massachusetts General 
      Hospital, 149 13th Street, Charlestown 02129, MA, USA.
FAU - Kushibiki, Toshihiro
AU  - Kushibiki T
AD  - Department of Medical Engineering, National Defense Medical College, 3-2 Namiki, 
      Tokorozawa, Saitama 359-8513, Japan.
FAU - Kawana, Akihiko
AU  - Kawana A
AD  - Division of Infectious Diseases and Respiratory Medicine, Department of Medicine, 
      National Defense Medical College, 3-2 Namiki, Tokorozawa, Saitama 359-8513, 
      Japan.
FAU - Kimizuka, Yoshifumi
AU  - Kimizuka Y
AD  - Division of Infectious Diseases and Respiratory Medicine, Department of Medicine, 
      National Defense Medical College, 3-2 Namiki, Tokorozawa, Saitama 359-8513, 
      Japan.
FAU - Kashiwagi, Satoshi
AU  - Kashiwagi S
AUID- ORCID: 0000-0001-8910-3257
AD  - Gordon Center for Medical Imaging, Department of Radiology, Massachusetts General 
      Hospital, 149 13th Street, Charlestown 02129, MA, USA.
LA  - eng
GR  - R01 AI105131/AI/NIAID NIH HHS/United States
GR  - R01 NS096237/NS/NINDS NIH HHS/United States
GR  - R21 AI144103/AI/NIAID NIH HHS/United States
PT  - Journal Article
DEP - 20210809
PL  - Germany
TA  - Nanophotonics
JT  - Nanophotonics
JID - 101607802
PMC - PMC8635068
MID - NIHMS1736805
OTO - NOTNLM
OT  - CD103+ dendritic cells
OT  - adjuvant
OT  - early antibody response
OT  - near-infrared laser
OT  - vaccine
COIS- Conflict of interest statement: The authors declare no conflicts of interest 
      regarding this article.
EDAT- 2021/12/07 06:00
MHDA- 2021/12/07 06:01
PMCR- 2022/09/01
CRDT- 2021/12/06 09:17
PHST- 2021/12/06 09:17 [entrez]
PHST- 2021/12/07 06:00 [pubmed]
PHST- 2021/12/07 06:01 [medline]
PHST- 2022/09/01 00:00 [pmc-release]
AID - 10.1515/nanoph-2021-0133 [doi]
PST - ppublish
SO  - Nanophotonics. 2021 Sep;10(12):3187-3197. doi: 10.1515/nanoph-2021-0133. Epub 
      2021 Aug 9.