PMID- 3486900
OWN - NLM
STAT- MEDLINE
DCOM- 19860707
LR  - 20061115
IS  - 0022-1767 (Print)
IS  - 0022-1767 (Linking)
VI  - 136
IP  - 12
DP  - 1986 Jun 15
TI  - Accessory cell competence of ovine oligodendrocytes in mitogenic activation of 
      human peripheral T cells.
PG  - 4460-3
AB  - The multiple sclerosis (MS) plaque is characterized by mononuclear inflammatory 
      cell infiltration, demyelination, loss of oligodendrocytes (OGC), and 
      proliferation of astrocytes. Although antigen-specific, Ia-dependent cellular 
      immune mechanisms have been sought in plaque pathogenesis, Ia-independent T cell 
      activation has not been actively investigated. We examined a potential role of 
      OGC in accessory cell-dependent T cell mitogenesis with the anti-T3 monoclonal 
      antibody OKT3. OGC isolated from ovine white matter on sucrose density gradients 
      were uniformly negative for esterase activity, unlike ovine monocytes. Purified 
      human T cells did not exhibit significant proliferation in 3-day cultures with 
      OKT3, autologous peripheral blood adherent cells (PBAC), or ovine OGC. When T 
      cells were cultured with either PABC or OGC in the presence of OKT3, brisk 
      mitogenesis was observed. Thus, OGC have the capacity to function as accessory 
      cells in the mitogen-induced proliferation of T cells.
FAU - Cashman, N R
AU  - Cashman NR
FAU - Noronha, A
AU  - Noronha A
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Immunol
JT  - Journal of immunology (Baltimore, Md. : 1950)
JID - 2985117R
RN  - 0 (Antibodies, Monoclonal)
RN  - 0 (Immunoglobulin G)
SB  - IM
MH  - Animals
MH  - Antibodies, Monoclonal/physiology
MH  - Antigen-Presenting Cells/*immunology
MH  - Binding, Competitive
MH  - Humans
MH  - Immunoglobulin G/physiology
MH  - *Lymphocyte Activation
MH  - Multiple Sclerosis/immunology
MH  - Neuroglia/*immunology
MH  - Oligodendroglia/*immunology
MH  - Sheep
MH  - T-Lymphocytes/*immunology
EDAT- 1986/06/15 00:00
MHDA- 1986/06/15 00:01
CRDT- 1986/06/15 00:00
PHST- 1986/06/15 00:00 [pubmed]
PHST- 1986/06/15 00:01 [medline]
PHST- 1986/06/15 00:00 [entrez]
PST - ppublish
SO  - J Immunol. 1986 Jun 15;136(12):4460-3.