PMID- 34869555
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20211207
IS  - 2296-875X (Print)
IS  - 2296-875X (Electronic)
IS  - 2296-875X (Linking)
VI  - 8
DP  - 2021
TI  - Effects of Preoperative Carbohydrate Intake on Inflammatory Markers and Clinical 
      Outcomes in Elderly Patients Undergoing Radical Prostatectomy: A Single-Centre, 
      Double-Blind Randomised Controlled Trial.
PG  - 744091
LID - 10.3389/fsurg.2021.744091 [doi]
LID - 744091
AB  - Background: This study aimed to analyse the effects of carbohydrate (CHO) intake 
      on inflammatory markers, comfort, and clinical outcomes in elderly patients 
      undergoing open radical prostatectomy. Methods: Patients aged >/=65 years who 
      underwent open radical prostatectomy were randomly divided into CHO, drinking 
      water, and fasting groups. A total of 90 patients were enrolled in this study 
      (CHO group, n = 28; placebo group, n = 30 and fasting group, n = 32). Patients in 
      the CHO group were given 800 and 400 ml of carbohydrates 8 and 2-3 h before 
      surgery, respectively. Patients in the placebo group were given 800 and 400 ml of 
      water 8 and 2-3 h before surgery, respectively. Patients in the fasting group did 
      not consume any liquids. The main result is levels of inflammation markers. 
      Secondary results included cellular immunity, comfort, body weight, grip index, 
      and clinical results. Results: Compared with the fasting group, the CHO group 
      exhibited a decrease in interleukin 6 (IL-6) levels on days 1 and 7 (75.47 and 
      7.06 pg/mL, respectively), IL-8 levels on day 1 (274.61 pg/mL) and tumour 
      necrosis factor (TNF) levels on days 1, 3, and 7 (11.16, 9.55, and 9.67 pg/mL, 
      respectively). The placebo group exhibited a decrease in IL-8 (390.26 pg/mL) and 
      TNF levels (13.99 pg/mL) on day 1. Compared with the placebo group, the CHO group 
      exhibited a decrease in IL-6 levels on day 1 and TNF levels on day 3. In the CHO 
      and placebo groups, the thirst and hunger scores decreased on the morning of 
      surgery. Conclusion: Preoperative CHO and drinking water are associated with 
      decreased levels of IL-6, IL-8, and TNF. CHO and water can also reduce thirst and 
      hunger scores. Therefore, we recommend that patients without contraindications 
      should be given 200-400 ml of fluid 2-3 h before surgery, preferably CHO. 
      Clinical Trial Registration: http://www.chictr.org.cn/edit.aspx?pid=21783&htm=4; 
      ChiCTR-INR-17012867.
CI  - Copyright (c) 2021 Hu, Liu and Wang.
FAU - Hu, Zhen
AU  - Hu Z
AD  - Shanghai Tenth People's Hospital, Tongji University, Shanghai, China.
FAU - Liu, Ji
AU  - Liu J
AD  - Shanghai Tenth People's Hospital, Tongji University, Shanghai, China.
FAU - Wang, Fen
AU  - Wang F
AD  - Shanghai Tenth People's Hospital, Tongji University, Shanghai, China.
LA  - eng
PT  - Case Reports
DEP - 20211118
PL  - Switzerland
TA  - Front Surg
JT  - Frontiers in surgery
JID - 101645127
PMC - PMC8636719
OTO - NOTNLM
OT  - carbohydrate
OT  - clinical outcomes
OT  - enhanced recovery after surgery (ERAS)
OT  - inflammatory markers
OT  - radical prostatectomy
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2021/12/07 06:00
MHDA- 2021/12/07 06:01
PMCR- 2021/11/18
CRDT- 2021/12/06 09:21
PHST- 2021/07/19 00:00 [received]
PHST- 2021/10/08 00:00 [accepted]
PHST- 2021/12/06 09:21 [entrez]
PHST- 2021/12/07 06:00 [pubmed]
PHST- 2021/12/07 06:01 [medline]
PHST- 2021/11/18 00:00 [pmc-release]
AID - 10.3389/fsurg.2021.744091 [doi]
PST - epublish
SO  - Front Surg. 2021 Nov 18;8:744091. doi: 10.3389/fsurg.2021.744091. eCollection 
      2021.