PMID- 34869629
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20211207
IS  - 2297-055X (Print)
IS  - 2297-055X (Electronic)
IS  - 2297-055X (Linking)
VI  - 8
DP  - 2021
TI  - Associations of Insomnia With Hypertension and Coronary Artery Disease Among 
      Patients With Type 2 Diabetes Mellitus.
PG  - 730654
LID - 10.3389/fcvm.2021.730654 [doi]
LID - 730654
AB  - Purpose: This study aimed to determine whether insomnia is associated with 
      hypertension (HBP) and coronary artery disease (CAD) in a hospital-based sample 
      of patients with type 2 diabetes mellitus (T2DM). Methods: Our present study 
      included 354 patients with T2DM. According to the diagnostic criteria of 
      insomnia, the participants were assigned to three groups based on the duration of 
      T2DM and insomnia diagnosis. Patients with T2DM alone were placed in group A; 
      patients with T2DM longer than insomnia were placed in group B; and patients with 
      insomnia longer than T2DM were placed in group C. Medical history was collected 
      from all the patients in detail. Besides, the participants underwent thorough 
      physical examinations and laboratory measurements. Propensity score matching 
      (PSM) was applied to evaluate the associations of insomnia with HBP and CAD. The 
      univariate and multivariate logistic regression analysis was used to explore 
      whether insomnia was a risk factor for HBP and CAD in patients with T2DM. 
      Results: Of 354 patients, 225 patients were included in group A, 62 patients were 
      included in group B, and 67 patients were included in group C. Compared with 
      groups B and C, group A showed a lower prevalence of HBP and CAD (p < 0.05). In 
      addition, compared with group B, group C showed no difference in the prevalence 
      of HBP and CAD (p > 0.05). After PSM was performed, groups B and C had a higher 
      prevalence of HBP and CAD (p < 0.05) than group A with no significant difference 
      between groups B and C (p > 0.05). In the univariate and multivariate logistic 
      regression analysis, insomnia was a risk factor for HBP [univariate: odds ratio 
      (OR) = 3.376, 95% CI 2.290-6.093, p < 0.001; multivariate: OR = 2.832, 95% CI 
      1.373-5.841, p = 0.005] and CAD (univariate: OR = 5.019, 95% CI 3.148-8.001, p < 
      0.001; multivariate: OR = 5.289, 95% CI 2.579-10.850, p < 0.001). Conclusion: 
      T2DM combined with insomnia was related to HBP and CAD and insomnia was a risk 
      factor for HBP and CAD in patients with T2DM. However, larger, prospective 
      studies are required to confirm our findings.
CI  - Copyright (c) 2021 Hu, Yan, Fu and Pan.
FAU - Hu, Yonghui
AU  - Hu Y
AD  - National Health Commission (NHC), Key Laboratory of Hormones and Development, 
      Tianjin Key Laboratory of Metabolic Diseases, Chu Hsien-I Memorial Hospital & 
      Tianjin Institute of Endocrinology, Tianjin Medical University, Tianjin, China.
FAU - Yan, Zhiyue
AU  - Yan Z
AD  - National Health Commission (NHC), Key Laboratory of Hormones and Development, 
      Tianjin Key Laboratory of Metabolic Diseases, Chu Hsien-I Memorial Hospital & 
      Tianjin Institute of Endocrinology, Tianjin Medical University, Tianjin, China.
FAU - Fu, Zhenrui
AU  - Fu Z
AD  - Department of Urology, Affiliated Zhongda Hospital of Southeast University, 
      Southeast University, Nanjing, China.
FAU - Pan, Congqing
AU  - Pan C
AD  - National Health Commission (NHC), Key Laboratory of Hormones and Development, 
      Tianjin Key Laboratory of Metabolic Diseases, Chu Hsien-I Memorial Hospital & 
      Tianjin Institute of Endocrinology, Tianjin Medical University, Tianjin, China.
LA  - eng
PT  - Journal Article
DEP - 20211119
PL  - Switzerland
TA  - Front Cardiovasc Med
JT  - Frontiers in cardiovascular medicine
JID - 101653388
PMC - PMC8639702
OTO - NOTNLM
OT  - coronary artery disease
OT  - hypertension
OT  - insomnia
OT  - propensity score matching
OT  - type 2 diabetes mellitus
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2021/12/07 06:00
MHDA- 2021/12/07 06:01
PMCR- 2021/01/01
CRDT- 2021/12/06 09:22
PHST- 2021/06/25 00:00 [received]
PHST- 2021/10/18 00:00 [accepted]
PHST- 2021/12/06 09:22 [entrez]
PHST- 2021/12/07 06:00 [pubmed]
PHST- 2021/12/07 06:01 [medline]
PHST- 2021/01/01 00:00 [pmc-release]
AID - 10.3389/fcvm.2021.730654 [doi]
PST - epublish
SO  - Front Cardiovasc Med. 2021 Nov 19;8:730654. doi: 10.3389/fcvm.2021.730654. 
      eCollection 2021.