PMID- 34869719
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20240228
IS  - 2297-1769 (Print)
IS  - 2297-1769 (Electronic)
IS  - 2297-1769 (Linking)
VI  - 8
DP  - 2021
TI  - Animal-Based Factors Prior to Infection Predict Histological Disease Outcome in 
      Porcine Reproductive and Respiratory Syndrome Virus- and Actinobacillus 
      pleuropneumoniae-Infected Pigs.
PG  - 742877
LID - 10.3389/fvets.2021.742877 [doi]
LID - 742877
AB  - A large variety of clinical manifestation in individual pigs occurs after 
      infection with pathogens involved in porcine respiratory disease complex (PRDC). 
      Some pigs are less prone to develop respiratory disease symptoms. The variation 
      in clinical impact after infection and the recovery capacity of an individual 
      animal are measures of its resilience. In this paper, we examined which ones of a 
      range of animal-based factors (rectal temperature, body weight, skin lesion 
      scores, behavior, natural antibody serum levels, serum levels of white blood 
      cells, and type of T and granulocyte subsets) when measured prior to infection 
      are related to disease severity. These animal-based factors and the interaction 
      with housing regimen of the piglets (conventional or enriched) were modeled using 
      linear regression to predict disease severity using a dataset acquired from a 
      previous study using a well-established experimental coinfection model of porcine 
      reproductive and respiratory syndrome virus (PRRSV) and Actinobacillus 
      pleuropneumoniae. Both PRRSV and A. pleuropneumoniae are often involved in PRDC. 
      Histological lung lesion score of each animal was used as a measure for PRDC 
      severity after infection. Prior to infection, higher serum levels of lymphocytes 
      (CD3(+)), naive T helper (CD3(+)CD4(+)CD8(-)), CD8(+) (as well as higher relative 
      levels of CD8(+)), and memory T helper (CD3(+)CD4(+)CD8(+)) cells and higher 
      relative levels of granulocytes (CD172(a)) were related to reduced disease 
      severity in both housing systems. Raised serum concentrations of natural IgM 
      antibodies binding to keyhole limpet hemocyanin (KLH) were also related to 
      reduced disease severity after infection. Increased levels of skin lesions at the 
      central body part (after weaning and before infection) were related to increased 
      disease severity in conventional housing systems only. High resisters showed a 
      lower histological lung lesion score, which appeared unrelated to sex. Body 
      temperature, behavior, and growth prior to infections were influenced by housing 
      regimen but could not explain the variation in lung lesion scores after 
      infection. Raised basal lymphocyte counts and lower skin lesion scores are 
      related to reduced disease severity independent of or dependent on housing 
      system, respectively. In conclusion, our study identifies intrinsic animal-based 
      measures using linear regression analysis that predicts resilience to infections 
      in pigs.
CI  - Copyright (c) 2021 van Dixhoorn, te Beest, Bolhuis, Parmentier, Kemp, van Mourik, 
      Stockhofe-Zurwieden, van Reenen and Rebel.
FAU - van Dixhoorn, Ingrid D E
AU  - van Dixhoorn IDE
AD  - Wageningen Livestock Research, Department of Animal Health and Welfare, 
      Wageningen, Netherlands.
FAU - Te Beest, Dennis E
AU  - Te Beest DE
AD  - Biometris, Wageningen University & Research, Wageningen, Netherlands.
FAU - Bolhuis, Jantina E
AU  - Bolhuis JE
AD  - Adaptation Physiology Group, Wageningen University & Research, Wageningen, 
      Netherlands.
FAU - Parmentier, Hendrik K
AU  - Parmentier HK
AD  - Adaptation Physiology Group, Wageningen University & Research, Wageningen, 
      Netherlands.
FAU - Kemp, Bas
AU  - Kemp B
AD  - Adaptation Physiology Group, Wageningen University & Research, Wageningen, 
      Netherlands.
FAU - van Mourik, Simon
AU  - van Mourik S
AD  - Farm Technology Group, Wageningen University & Research, Wageningen, Netherlands.
FAU - Stockhofe-Zurwieden, Norbert
AU  - Stockhofe-Zurwieden N
AD  - Wageningen Bio-Veterinary Research, Lelystad, Netherlands.
FAU - van Reenen, Cornelis G
AU  - van Reenen CG
AD  - Wageningen Livestock Research, Department of Animal Health and Welfare, 
      Wageningen, Netherlands.
FAU - Rebel, Johanna M J
AU  - Rebel JMJ
AD  - Wageningen Livestock Research, Department of Animal Health and Welfare, 
      Wageningen, Netherlands.
LA  - eng
PT  - Journal Article
DEP - 20211117
PL  - Switzerland
TA  - Front Vet Sci
JT  - Frontiers in veterinary science
JID - 101666658
EIN - Front Vet Sci. 2024 Feb 13;11:1350387. PMID: 38414652
PMC - PMC8635501
OTO - NOTNLM
OT  - Actinobacillus pleuropneumoniae
OT  - PRRSV
OT  - animal-based factors
OT  - coping strategy
OT  - disease severity
OT  - enriched housing
OT  - porcine respiratory disease
OT  - resilience indicators
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2021/12/07 06:00
MHDA- 2021/12/07 06:01
PMCR- 2021/01/01
CRDT- 2021/12/06 09:22
PHST- 2021/07/16 00:00 [received]
PHST- 2021/10/12 00:00 [accepted]
PHST- 2021/12/06 09:22 [entrez]
PHST- 2021/12/07 06:00 [pubmed]
PHST- 2021/12/07 06:01 [medline]
PHST- 2021/01/01 00:00 [pmc-release]
AID - 10.3389/fvets.2021.742877 [doi]
PST - epublish
SO  - Front Vet Sci. 2021 Nov 17;8:742877. doi: 10.3389/fvets.2021.742877. eCollection 
      2021.