PMID- 34870139
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220428
IS  - 2589-9368 (Electronic)
IS  - 2589-9368 (Linking)
VI  - 12
DP  - 2021 Dec
TI  - Protective effects of cerium oxide nanoparticles in non-alcoholic fatty liver 
      disease (NAFLD) and carbon tetrachloride-induced liver damage in rats: Study on 
      intestine and liver.
PG  - 100151
LID - 10.1016/j.metop.2021.100151 [doi]
LID - 100151
AB  - BACKGROUND AND AIMS: Nanoparticles could represent a therapeutic approach for the 
      treatment of various diseases. It has been reported that cerium oxide 
      nanoparticles (CeO(2) NPs) have potential useful effects. Therefore, we aimed to 
      examine the protective effects of the CeO(2) NPs in two models of liver injury, 
      non-alcoholic fatty liver disease (NAFLD) and carbon tetrachloride 
      (CCl(4))-induced liver fibrosis, in rats. METHODS: In this experimental study, 
      male rats were randomly divided into different experimental groups including: 
      Experiment 1; group1: healthy rats received normal saline, 2: CCl(4) group, 3: 
      CCl(4) + nanoparticle. Experiment 2; group1: healthy rats received chow diet, 2: 
      NAFLD group, 3: NAFLD + nanoparticle. The oxidative stress markers were 
      determined in the liver and intestine. Tumor necrosis factor-alpha (TNF-alpha) levels 
      were measured by ELISA. Histopathological changes of liver and intestine were 
      evaluated by light microspore. RESULTS: Total antioxidant capacity (TAC) and 
      glutathione (GSH) levels significantly decreased, while malondialdehyde (MDA) and 
      total oxidant status (TOS) were significantly increased in the liver, and 
      intestine of the NAFLD and CCl(4) group compared with control rats. However, the 
      use of nanoparticles significantly normalized these markers. The levels of the 
      TNF-alpha were significantly reduced in the nanoparticle group as compared with NAFLD 
      model and CCl(4)-treated rats. CeO(2) NPs also normalized the liver and 
      intestinal histological changes. CONCLUSIONS: Our finding revealed that CeO(2) 
      NPs has potential protective effects by increasing antioxidant activity, and 
      reducing inflammation.
CI  - (c) 2021 The Authors. Published by Elsevier Inc.
FAU - Abbasi, Ebrahim
AU  - Abbasi E
AD  - Department of Biochemistry, School of Medicine, Hamadan University of Medical 
      Sciences, Hamadan, Iran.
FAU - Vafaei, Seyed Alireza
AU  - Vafaei SA
AD  - Department of Biology, Islamic Azad University, Sanandaj Branch, Sanandaj, Iran.
FAU - Naseri, Nima
AU  - Naseri N
AD  - Department of Biochemistry, School of Medicine, Hamadan University of Medical 
      Sciences, Hamadan, Iran.
FAU - Darini, Ali
AU  - Darini A
AD  - Department of Nanotechnology, Pharmaceutical Sciences Branch, Islamic Azad 
      University (IAUPS), Tehran, Iran.
FAU - Azandaryani, Masoumeh Taheri
AU  - Azandaryani MT
AD  - Department of Neurophysiology Research Center, Hamadan University of Medical 
      Sciences, Hamadan, Iran.
FAU - Ara, Farhad Kian
AU  - Ara FK
AD  - Medical Biology Research Center, Kermanshah University of Medical Sciences, 
      Kermanshah, Iran.
FAU - Mirzaei, Fatemeh
AU  - Mirzaei F
AD  - Department of Anatomy, School of Medicine, Hamadan University of Medical 
      Sciences, Hamadan, Iran.
LA  - eng
PT  - Journal Article
DEP - 20211118
PL  - England
TA  - Metabol Open
JT  - Metabolism open
JID - 101767753
PMC - PMC8626579
OTO - NOTNLM
OT  - Carbon tetrachloride
OT  - Cerium oxide nanoparticles
OT  - Inflammation
OT  - Liver injury
OT  - Rats
EDAT- 2021/12/07 06:00
MHDA- 2021/12/07 06:01
PMCR- 2021/11/18
CRDT- 2021/12/06 09:27
PHST- 2021/08/31 00:00 [received]
PHST- 2021/11/04 00:00 [revised]
PHST- 2021/11/05 00:00 [accepted]
PHST- 2021/12/06 09:27 [entrez]
PHST- 2021/12/07 06:00 [pubmed]
PHST- 2021/12/07 06:01 [medline]
PHST- 2021/11/18 00:00 [pmc-release]
AID - S2589-9368(21)00075-X [pii]
AID - 100151 [pii]
AID - 10.1016/j.metop.2021.100151 [doi]
PST - epublish
SO  - Metabol Open. 2021 Nov 18;12:100151. doi: 10.1016/j.metop.2021.100151. 
      eCollection 2021 Dec.