PMID- 34870166
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220429
IS  - 2618-6500 (Electronic)
IS  - 2148-5046 (Print)
IS  - 2148-5046 (Linking)
VI  - 36
IP  - 3
DP  - 2021 Sep
TI  - Evaluating various radiographic methods of shoulder joint damage in patients with 
      rheumatoid arthritis receiving biological disease-modifying antirheumatic drugs.
PG  - 349-359
LID - 10.46497/ArchRheumatol.2021.8236 [doi]
AB  - OBJECTIVES: This study aims to clarify shoulder joint damage in rheumatoid 
      arthritis patients receiving biological disease-modifying antirheumatic drugs 
      (bDMARDs) and the relationship between joint damage and clinical factors. 
      PATIENTS AND METHODS: In this retrospective study conducted between April 2005 
      and December 2008, 36 shoulders in 19 patients (2 males, 17 females; mean age: 
      58.9 years; range 42 to 75 years) were evaluated at baseline and two years after 
      the initiation of bDMARD therapy with infliximab (n=14) or etanercept (n=5). 
      Standard anteroposterior radiographs of the shoulder joints were taken at 
      baseline and two years after institution of biological therapy. Structural damage 
      in the shoulder joints was assessed using the Larsen scoring method, the medial 
      displacement index (MDI), and the upward migration index (UMI). RESULTS: There 
      was a significant correlation between MDI, UMI, and Larsen grade before 
      biological therapy. Univariate analysis revealed that the disease activity score 
      28-count erythrocyte sedimentation rate (ESR) at baseline (odds ratio [OR]: 
      4.298) was associated with progression of MDI. But multivariate logistic 
      regression revealed that there was no association with the progression of MDI. 
      Univariate analysis revealed that ESR at baseline (OR: 0.967) and matrix 
      metalloproteinase-3 (MMP-3) at baseline (OR: 0.996) were associated with the 
      progression of UMI. Multivariate logistic regression revealed that MMP-3 at 
      baseline (OR: 0.994) was independently associated with the progression of UMI. 
      CONCLUSION: Medial displacement index and UMI correlated with the Larsen grade of 
      the shoulder joint strongly and moderately, respectively. This study suggests 
      that MDI and UMI may help to evaluate radiographic progression of damage in 
      shoulder joints in patients on bDMARDs, which is difficult to detect using the 
      Larsen grade.
CI  - Copyright (c) 2021, Turkish League Against Rheumatism.
FAU - Sugimori, Kazuhito
AU  - Sugimori K
AUID- ORCID: 0000-0001-8826-9642
AD  - Department of Orthopaedic Surgery, Toyama Red Cross Hospital, Toyama, Japan.
FAU - Matsushita, Isao
AU  - Matsushita I
AUID- ORCID: 0000-0002-8210-7965
AD  - Department of Orthopaedic Surgery, Faculty of Medicine, University of Toyama, 
      Toyama, Japan.
FAU - Kimura, Tomoatsu
AU  - Kimura T
AUID- ORCID: 0000-0003-1417-8371
AD  - Department of Orthopaedic Surgery, Faculty of Medicine, University of Toyama, 
      Toyama, Japan.
LA  - eng
PT  - Journal Article
DEP - 20201212
PL  - Turkey
TA  - Arch Rheumatol
JT  - Archives of rheumatology
JID - 101639000
PMC - PMC8612484
OTO - NOTNLM
OT  - Rheumatoid arthritis
OT  - shoulder joint
OT  - tumor necrosis factor-alpha
COIS- Conflict of Interest: The authors declared no conflicts of interest with respect 
      to the authorship and/or publication of this article.
EDAT- 2021/12/07 06:00
MHDA- 2021/12/07 06:01
PMCR- 2020/12/12
CRDT- 2021/12/06 09:28
PHST- 2020/05/26 00:00 [received]
PHST- 2020/07/16 00:00 [accepted]
PHST- 2021/12/06 09:28 [entrez]
PHST- 2021/12/07 06:00 [pubmed]
PHST- 2021/12/07 06:01 [medline]
PHST- 2020/12/12 00:00 [pmc-release]
AID - 10.46497/ArchRheumatol.2021.8236 [doi]
PST - epublish
SO  - Arch Rheumatol. 2020 Dec 12;36(3):349-359. doi: 10.46497/ArchRheumatol.2021.8236. 
      eCollection 2021 Sep.