PMID- 34870282
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20221102
IS  - 2699-9307 (Electronic)
IS  - 2699-9307 (Linking)
VI  - 1
IP  - 11
DP  - 2021 Nov
TI  - Esterase-activatable and GSH-responsive Triptolide Nano-prodrug for the 
      Eradication of Pancreatic Cancer.
LID - 2100040 [pii]
LID - 10.1002/anbr.202100040 [doi]
AB  - Triptolide (TPL) is a small molecule isolated from a traditional Chinese herb 
      Tripterygium wilfordii Hook F and shows excellent anticancer effect for 
      pancreatic cancer cells. However, the poor water solubility and severe liver 
      toxicity of TPL hindered its clinical application. In this study, TPL was 
      covalently conjugated to a polymer and entrapped inside the core of the TPL 
      nanogel (nTPL) to protect it from premature leakage during blood circulation. 
      With the help of lactobionic acid (LBA), nTPL-LBA could selectively target the 
      tumors in an orthotopic pancreatic cancer mouse model. TPL could be subsequently 
      released intracellularly in its original form due to the presence of elevated 
      intracellular esterase and GSH, and eventually kills cancer cells. nTPL-LBA 
      treatment reduced tumor burden by 99% while not introducing TPL associated liver 
      and kidney toxicities. Most importantly, more than half of the nTPL-LBA treated 
      animals were tumor-free, suggesting that nTPL-LBA is an effective approach in 
      eradicating pancreatic cancer.
FAU - Sui, Binglin
AU  - Sui B
AD  - Department of Drug Discovery and Biomedical Sciences, College of Pharmacy, 
      University of South Carolina, 715 Sumter St., Columbia, SC 29208, United States.
FAU - Cheng, Chen
AU  - Cheng C
AD  - Department of Drug Discovery and Biomedical Sciences, College of Pharmacy, 
      University of South Carolina, 715 Sumter St., Columbia, SC 29208, United States.
FAU - Shi, Shanshan
AU  - Shi S
AD  - Department of Drug Discovery and Biomedical Sciences, College of Pharmacy, 
      University of South Carolina, 715 Sumter St., Columbia, SC 29208, United States.
FAU - Wang, Mingming
AU  - Wang M
AD  - Department of Drug Discovery and Biomedical Sciences, College of Pharmacy, 
      University of South Carolina, 715 Sumter St., Columbia, SC 29208, United States.
FAU - Xu, Peisheng
AU  - Xu P
AD  - Department of Drug Discovery and Biomedical Sciences, College of Pharmacy, 
      University of South Carolina, 715 Sumter St., Columbia, SC 29208, United States.
LA  - eng
GR  - R01 AG054839/AG/NIA NIH HHS/United States
GR  - R21 CA252360/CA/NCI NIH HHS/United States
GR  - R41 CA254500/CA/NCI NIH HHS/United States
PT  - Journal Article
DEP - 20210802
PL  - Germany
TA  - Adv Nanobiomed Res
JT  - Advanced nanobiomed research
JID - 101773117
PMC - PMC8635305
MID - NIHMS1730449
OTO - NOTNLM
OT  - Triptolide
OT  - esterase-activatable
OT  - intracellular release
OT  - nano-prodrug
OT  - pancreatic cancer
EDAT- 2021/12/07 06:00
MHDA- 2021/12/07 06:01
PMCR- 2022/11/01
CRDT- 2021/12/06 09:30
PHST- 2021/12/06 09:30 [entrez]
PHST- 2021/12/07 06:00 [pubmed]
PHST- 2021/12/07 06:01 [medline]
PHST- 2022/11/01 00:00 [pmc-release]
AID - 2100040 [pii]
AID - 10.1002/anbr.202100040 [doi]
PST - ppublish
SO  - Adv Nanobiomed Res. 2021 Nov;1(11):2100040. doi: 10.1002/anbr.202100040. Epub 
      2021 Aug 2.