PMID- 34871160
OWN - NLM
STAT- MEDLINE
DCOM- 20211217
LR  - 20220104
IS  - 1539-6304 (Electronic)
IS  - 1088-5412 (Print)
IS  - 1088-5412 (Linking)
VI  - 42
IP  - 6
DP  - 2021 Nov 1
TI  - Does aeroallergen sensitivity and allergic rhinitis in children cause milder 
      COVID-19 infection?
PG  - 522-529
LID - 10.2500/aap.2021.42.210087 [doi]
AB  - Background: There are conflicting data with regard to the impact of respiratory 
      and allergic comorbidities on the course of novel coronavirus disease 2019 
      (COVID-19) in children. Objective: This study aimed to investigate the 
      relationship between allergic diseases and COVID-19 severity in pediatric 
      patients. Methods: Seventy-five pediatric patients with COVID-19 were classified 
      according to clinical severity and evaluated in the allergy/immunology and 
      pulmonology departments 1 to 3 months after the infection resolved. Blood was 
      collected from the patients for a complete blood cell count and assessment of 
      immunoglobulin and total immunoglobulin E (IgE) levels, and skin-prick tests and 
      spirometry tests were performed. Results: A total of 75 patients ages 5-18 years 
      were evaluated. COVID-19 was asymptomatic/mild in 44 patients and 
      moderate/severe/critical in 31 patients. Based on allergy evaluation, allergic 
      rhinitis was diagnosed in 19 patients (25.3%), asthma in 10 patients (13%), and 
      atopic dermatitis in 3 patients (4%). Aeroallergen sensitivity was detected in 26 
      patients (34.7%). COVID-19 infection was asymptomatic/mild in 15 patients with 
      allergic rhinitis (78.9%) and in 21 with aeroallergen sensitivity (80.8%) (p = 
      0.038 and p = 0.005, respectively). There was no difference in severity between 
      the patients with and without asthma (p = 0.550). The median (interquartile 
      range) total IgE level was significantly higher in the asymptomatic/mild group 
      (71.8 [30.7-211.2]) (p = 0.015). There were no differences in terms of spirometry 
      parameters. Conclusion: Aeroallergen sensitization and allergic rhinitis in 
      children may be associated with a milder course of COVID-19. The knowledge that 
      atopy is associated with less-severe COVID-19 outcomes in children may guide 
      clinical risk classification.
FAU - Vezir, Emine
AU  - Vezir E
AD  - From the Department of Pediatric Allergy and Clinical Immunology, University of 
      Health Sciences, Ankara Training and Research Hospital, Ankara, Turkey.
FAU - Hizal, Mina
AU  - Hizal M
AD  - Department of Pediatric Pulmonology, University of Health Sciences, Ankara 
      Training and Research Hospital, Ankara, Turkey.
FAU - Cura Yayla, Burcu
AU  - Cura Yayla B
AD  - Department of Pediatric Infectious Disease, University of Health Sciences, Ankara 
      Training and Research Hospital, Ankara, Turkey.
FAU - Aykac, Kubra
AU  - Aykac K
AD  - Department of Pediatric Infectious Disease, University of Health Sciences, Ankara 
      Training and Research Hospital, Ankara, Turkey.
FAU - Yilmaz, Arzu
AU  - Yilmaz A
AD  - Department of Pediatrics, University of Health Sciences, Ankara Training and 
      Research Hospital, Ankara, Turkey, and.
FAU - Kaya, Gamze
AU  - Kaya G
AD  - Department of Pediatrics, University of Health Sciences, Ankara Training and 
      Research Hospital, Ankara, Turkey, and.
FAU - Oygar, Pembe Derin
AU  - Oygar PD
AD  - Department of Pediatric Infectious Disease, Faculty of Medicine, Hacettepe 
      University, Ankara, Turkey.
FAU - Ozsurekci, Yasemin
AU  - Ozsurekci Y
AD  - Department of Pediatric Infectious Disease, Faculty of Medicine, Hacettepe 
      University, Ankara, Turkey.
FAU - Ceyhan, Mehmet
AU  - Ceyhan M
AD  - Department of Pediatric Infectious Disease, Faculty of Medicine, Hacettepe 
      University, Ankara, Turkey.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Allergy Asthma Proc
JT  - Allergy and asthma proceedings
JID - 9603640
RN  - 0 (Allergens)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Adolescent
MH  - Allergens/*adverse effects
MH  - Asthma/*diagnosis/epidemiology/immunology
MH  - COVID-19/*complications/diagnosis/epidemiology
MH  - Child
MH  - Child, Preschool
MH  - Dermatitis, Atopic/*diagnosis/epidemiology/immunology
MH  - Female
MH  - Humans
MH  - Hypersensitivity/*diagnosis/epidemiology/immunology
MH  - Immunoglobulin E/blood
MH  - Male
MH  - Respiratory Function Tests
MH  - Rhinitis, Allergic/*diagnosis/epidemiology/immunology
MH  - SARS-CoV-2
MH  - Severity of Illness Index
MH  - Skin Tests/*statistics & numerical data
MH  - Turkey/epidemiology
PMC - PMC8654388
COIS- The authors have no conflicts of interest to declare pertaining to this article.
EDAT- 2021/12/07 06:00
MHDA- 2021/12/18 06:00
PMCR- 2021/11/01
CRDT- 2021/12/06 17:18
PHST- 2021/12/06 17:18 [entrez]
PHST- 2021/12/07 06:00 [pubmed]
PHST- 2021/12/18 06:00 [medline]
PHST- 2021/11/01 00:00 [pmc-release]
AID - AAP230-21 [pii]
AID - 10.2500/aap.2021.42.210087 [doi]
PST - ppublish
SO  - Allergy Asthma Proc. 2021 Nov 1;42(6):522-529. doi: 10.2500/aap.2021.42.210087.