PMID- 34871429
OWN - NLM
STAT- MEDLINE
DCOM- 20220426
LR  - 20240109
IS  - 1541-6100 (Electronic)
IS  - 0022-3166 (Print)
IS  - 0022-3166 (Linking)
VI  - 152
IP  - 3
DP  - 2022 Mar 3
TI  - Habitual Intake of Marine-Derived n-3 PUFAs is Inversely Associated with a 
      Cardiometabolic Inflammatory Profile in Yup'ik Alaska Native People.
PG  - 844-855
LID - 10.1093/jn/nxab412 [doi]
AB  - BACKGROUND: The relationship between dietary n-3 PUFAs and the prevention of 
      cardiometabolic diseases, including type 2 diabetes, is unresolved. Examination 
      of the association between n-3 PUFAs and chronic low-grade inflammation in a 
      population where many individuals have had an extremely high intake of marine 
      mammals and fish throughout their lifespan may provide important clues regarding 
      the impact of n-3 PUFAs on health. OBJECTIVES: The aim of this study was to 
      explore associations between concentrations of n-3 PUFAs resulting from habitual 
      intake of natural food sources high in fish and marine mammals with immune 
      biomarkers of metabolic inflammation and parameters of glucose regulation. 
      METHODS: A total of 569 Yup'ik Alaska Native adults (18-87 years old) were 
      enrolled in this cross-sectional study between December 2016 and November 2019. 
      The RBC nitrogen isotope ratio (NIR; 15N/14N) was used as a validated measure of 
      n-3 PUFA intake to select 165 participant samples from the first and fourth 
      quartiles of n-3 PUFA intakes. Outcomes included 38 pro- and anti-inflammatory 
      cytokines and 8 measures of glucose homeostasis associated with type 2 diabetes 
      risks. These outcomes were evaluated for their associations with direct 
      measurements of EPA, DHA, and arachidonic acid in RBCs. ANALYSIS: Linear 
      regression was used to detect significant relationships with cytokines and n-3 
      PUFAs, adiposity, and glucose-related variables. RESULTS: The DHA concentration 
      in RBC membranes was inversely associated with IL-6 (beta = -0.0066; P < 0.001); EPA 
      was inversely associated with TNFalpha (beta = -0.4925; P < 0.001); and the NIR was 
      inversely associated with Monocyte chemoattractant protein-1 (MCP-1) (beta = 
      -0.8345; P < 0.001) and IL-10 (beta = -1.2868; P < 0.001). CONCLUSIONS: Habitual 
      intake of marine mammals and fish rich in n-3 PUFAs in this study population of 
      Yup'ik Alaska Native adults is associated with reduced systemic inflammation, 
      which may contribute to the low prevalence of diseases in which inflammation 
      plays an important role.
CI  - (c) The Author(s) 2021. Published by Oxford University Press on behalf of the 
      American Society for Nutrition.
FAU - Boyer, Bert B
AU  - Boyer BB
AD  - Department of Obstetrics and Gynecology, Oregon Health & Science University, 
      Portland, OR, USA.
FAU - Hopkins, Scarlett E
AU  - Hopkins SE
AD  - Department of Obstetrics and Gynecology, Oregon Health & Science University, 
      Portland, OR, USA.
FAU - Wiener, Howard W
AU  - Wiener HW
AD  - Department of Statistics, University of Alabama at Birmingham, Birmingham, AL, 
      USA.
FAU - Purnell, Jonathan Q
AU  - Purnell JQ
AUID- ORCID: 0000-0001-5505-6333
AD  - Department of Medicine, Oregon Health & Science University, Portland, OR, USA.
FAU - O'Brien, Diane M
AU  - O'Brien DM
AUID- ORCID: 0000-0001-5807-9661
AD  - Department of Biology and Wildlife, University of Alaska Fairbanks, Fairbanks, 
      AK, USA.
FAU - Zhang, Cindy X
AU  - Zhang CX
AD  - Department of Pharmaceutics, University of Washington, Seattle, WA, USA.
FAU - Aslan, Joseph E
AU  - Aslan JE
AD  - Department of Medicine, Oregon Health & Science University, Portland, OR, USA.
FAU - Aliwarga, Theresa
AU  - Aliwarga T
AD  - Department of Pharmaceutics, University of Washington, Seattle, WA, USA.
FAU - Pomeroy, Jeremy J
AU  - Pomeroy JJ
AD  - Clinical Research Center, Marshfield Clinic, Marshfield, WI, USA.
FAU - Thummel, Kenneth E
AU  - Thummel KE
AUID- ORCID: 0000-0002-7799-3739
AD  - Department of Pharmaceutics, University of Washington, Seattle, WA, USA.
FAU - Tiwari, Hemant K
AU  - Tiwari HK
AD  - Department of Statistics, University of Alabama at Birmingham, Birmingham, AL, 
      USA.
LA  - eng
GR  - P51 OD011092/OD/NIH HHS/United States
GR  - R01 HL146549/HL/NHLBI NIH HHS/United States
GR  - R01 DK104347/DK/NIDDK NIH HHS/United States
GR  - P30 GM103325/GM/NIGMS NIH HHS/United States
GR  - R01 DK112358/DK/NIDDK NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PL  - United States
TA  - J Nutr
JT  - The Journal of nutrition
JID - 0404243
RN  - 0 (Cytokines)
RN  - 0 (Fatty Acids, Omega-3)
RN  - IY9XDZ35W2 (Glucose)
SB  - IM
EIN - J Nutr. 2023 Jun;153(6):1834-1836. PMID: 37084772
MH  - *Alaska Natives
MH  - Animals
MH  - *Cardiovascular Diseases
MH  - Cross-Sectional Studies
MH  - Cytokines
MH  - *Diabetes Mellitus, Type 2/prevention & control
MH  - *Fatty Acids, Omega-3/metabolism/pharmacology
MH  - Fishes/metabolism
MH  - Glucose
MH  - Humans
MH  - Inflammation
MH  - Mammals
PMC - PMC8891177
OTO - NOTNLM
OT  - chemokines
OT  - cytokines
OT  - fish oil
OT  - immune biomarkers
OT  - omega fatty acids
EDAT- 2021/12/07 06:00
MHDA- 2022/04/27 06:00
PMCR- 2022/12/06
CRDT- 2021/12/06 17:30
PHST- 2021/09/13 00:00 [received]
PHST- 2021/11/17 00:00 [revised]
PHST- 2021/12/01 00:00 [accepted]
PHST- 2021/12/07 06:00 [pubmed]
PHST- 2022/04/27 06:00 [medline]
PHST- 2021/12/06 17:30 [entrez]
PHST- 2022/12/06 00:00 [pmc-release]
AID - S0022-3166(22)00566-1 [pii]
AID - nxab412 [pii]
AID - 10.1093/jn/nxab412 [doi]
PST - ppublish
SO  - J Nutr. 2022 Mar 3;152(3):844-855. doi: 10.1093/jn/nxab412.