PMID- 34871718
OWN - NLM
STAT- MEDLINE
DCOM- 20220502
LR  - 20220502
IS  - 1873-1899 (Electronic)
IS  - 0734-9750 (Linking)
VI  - 55
DP  - 2022 Mar-Apr
TI  - Biological production of medium-chain carboxylates through chain elongation: An 
      overview.
PG  - 107882
LID - S0734-9750(21)00188-9 [pii]
LID - 10.1016/j.biotechadv.2021.107882 [doi]
AB  - Medium chain carboxylates (MCCs) have wide applications in various industries, 
      but the traditional MCCs production methods are costly and unsustainable. 
      Anaerobic fermentation offers a more scalable, economical and eco-friendly 
      platform for producing MCCs through chain elongation which converts short chain 
      carboxylates and electron donor into more valuable MCCs. However, the underlying 
      microbial pathways are not well understood. In this review, biological production 
      of MCCs through chain elongation is introduced elaborately, including the 
      metabolic pathways, electron donor and substrates, microorganisms and influencing 
      factors. Then, the strategies for enhancing MCCs production are extensively 
      analyzed and summarized, along with the technologies for MCCs separation from the 
      fermentation broth. Finally, challenges and perspectives concerning the 
      large-scale MCCs production are proposed, providing suggestions for the future 
      research. Extensive review demonstrated that anaerobic fermentation has great 
      potential in achieving economical and sustainable MCCs production from complex 
      organic substrates, including organic waste streams, which would significantly 
      broaden the application of MCCs, especially in the renewable energy field. An 
      interdisciplinary approach with knowledge from microbiology and biochemistry to 
      chemical separations and environmental engineering is required to use this 
      promising technology as a valorization method for converting organic biomass or 
      organic wastes into valuable MCCs.
CI  - Copyright (c) 2021 Elsevier Inc. All rights reserved.
FAU - Wang, Jianlong
AU  - Wang J
AD  - Laboratory of Environmental Technology, INET, Tsinghua University, Beijing 
      100084, PR China; Beijing Key Laboratory of Radioactive Waste Treatment, Tsinghua 
      University, Beijing 100084, PR China. Electronic address: wangjl@tsinghua.edu.cn.
FAU - Yin, Yanan
AU  - Yin Y
AD  - Laboratory of Environmental Technology, INET, Tsinghua University, Beijing 
      100084, PR China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20211203
PL  - England
TA  - Biotechnol Adv
JT  - Biotechnology advances
JID - 8403708
RN  - 0 (Carboxylic Acids)
RN  - 0 (Culture Media)
SB  - IM
MH  - *Carboxylic Acids
MH  - Culture Media
MH  - Fermentation
MH  - *Metabolic Networks and Pathways
OTO - NOTNLM
OT  - Anaerobic fermentation
OT  - Chain elongation
OT  - Electron donor
OT  - Medium chain carboxylates
OT  - Metabolic pathway
OT  - Renewable energy
EDAT- 2021/12/07 06:00
MHDA- 2022/05/03 06:00
CRDT- 2021/12/06 20:14
PHST- 2021/08/26 00:00 [received]
PHST- 2021/11/01 00:00 [revised]
PHST- 2021/11/28 00:00 [accepted]
PHST- 2021/12/07 06:00 [pubmed]
PHST- 2022/05/03 06:00 [medline]
PHST- 2021/12/06 20:14 [entrez]
AID - S0734-9750(21)00188-9 [pii]
AID - 10.1016/j.biotechadv.2021.107882 [doi]
PST - ppublish
SO  - Biotechnol Adv. 2022 Mar-Apr;55:107882. doi: 10.1016/j.biotechadv.2021.107882. 
      Epub 2021 Dec 3.