PMID- 34873110
OWN - NLM
STAT- MEDLINE
DCOM- 20220316
LR  - 20220316
IS  - 1473-558X (Electronic)
IS  - 0959-4965 (Linking)
VI  - 33
IP  - 2
DP  - 2022 Jan 19
TI  - Disrupted functional connectivity between the nucleus accumbens and posterior 
      cingulate cortex in autism spectrum disorder.
PG  - 43-47
LID - 10.1097/WNR.0000000000001742 [doi]
AB  - OBJECTIVES: Dysfunctions in the basal ganglia have been repeatedly found in 
      autism spectrum disorder (ASD). The nucleus accumbens (NAcc) is known for its 
      central role in social functions and also in its abnormality in ASD. In this 
      study, whole-brain functional connectivity of the NAcc was examined to isolate 
      brain regions that are differently connected to the NAcc in autism, using 
      resting-state functional MRI (rs-fMRI) data. METHODS: In the initial dataset, 68 
      individuals with ASD (13.13 +/- 2.41 years old) and 77 typically developing 
      individuals (14.79 +/- 3.57 years old) were compared. RESULTS: The precuneus 
      cortex, lingual gyrus, thalamus, dorsal striatum, anterior cingulate cortex and 
      posterior cingulate cortex showed weaker connectivity to the NAcc in the group 
      with ASD. Among these regions, dysconnectivity of the posterior cingulate cortex 
      (PCC) was replicated in the replication dataset, with 78 individuals with ASD and 
      105 without ASD. CONCLUSIONS: This study suggests that the dysconnectivity 
      between the NAcc and PCC may account for social dysfunctions in ASD.
CI  - Copyright (c) 2021 Wolters Kluwer Health, Inc. All rights reserved.
FAU - Polk, MaryScott
AU  - Polk M
AD  - School of Law, University of Mississippi.
FAU - Ikuta, Toshikazu
AU  - Ikuta T
AD  - Department of Communication Sciences and Disorders, School of Applied Sciences, 
      University of Mississippi, Mississippi, USA.
LA  - eng
GR  - U19 HD035482/HD/NICHD NIH HHS/United States
GR  - R21 MH079871/MH/NIMH NIH HHS/United States
GR  - UL1 RR024986/RR/NCRR NIH HHS/United States
GR  - K23 MH087770/MH/NIMH NIH HHS/United States
GR  - R21 MH084126/MH/NIMH NIH HHS/United States
GR  - R01 MH081218/MH/NIMH NIH HHS/United States
GR  - R01 HD065282/HD/NICHD NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Neuroreport
JT  - Neuroreport
JID - 9100935
SB  - IM
MH  - Adolescent
MH  - *Autism Spectrum Disorder/diagnostic imaging
MH  - Brain
MH  - Brain Mapping
MH  - Child
MH  - *Gyrus Cinguli/diagnostic imaging
MH  - Humans
MH  - Magnetic Resonance Imaging
MH  - Neural Pathways/diagnostic imaging
MH  - Nucleus Accumbens/diagnostic imaging
EDAT- 2021/12/08 06:00
MHDA- 2022/03/17 06:00
CRDT- 2021/12/07 06:00
PHST- 2021/12/08 06:00 [pubmed]
PHST- 2022/03/17 06:00 [medline]
PHST- 2021/12/07 06:00 [entrez]
AID - 00001756-202201020-00007 [pii]
AID - 10.1097/WNR.0000000000001742 [doi]
PST - ppublish
SO  - Neuroreport. 2022 Jan 19;33(2):43-47. doi: 10.1097/WNR.0000000000001742.