PMID- 34873177
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230210
IS  - 2058-7716 (Print)
IS  - 2058-7716 (Electronic)
IS  - 2058-7716 (Linking)
VI  - 7
IP  - 1
DP  - 2021 Dec 7
TI  - Corticotropin releasing hormone promotes inflammatory bowel disease via inducing 
      intestinal macrophage autophagy.
PG  - 377
LID - 10.1038/s41420-021-00767-8 [doi]
LID - 377
AB  - Psychosocial stress is a vital factor contributing to the pathogenesis and 
      progression of inflammatory bowel disease (IBD). The contribution of intestinal 
      macrophage autophagy to the onset and development of IBD has been widely studied. 
      Herein, we investigated the underlying mechanism of psychosocial stress in an IBD 
      mouse model pertaining to macrophage autophagy. Corticotropin releasing hormone 
      (CRH) was peripherally administrated to induce psychosocial stress. For in vivo 
      studies, dextran sulfate sodium (DSS) was used for the creation of our IBD mouse 
      model. For in vitro studies, lipopolysaccharide (LPS) was applied on murine bone 
      marrow-derived macrophages (BMDMs) as a cellular IBD-related challenge. 
      Chloroquine was applied to inhibit autophagy. We found that CRH aggravated the 
      severity of DSS-induced IBD, increasing overall and local inflammatory reactions 
      and infiltration. The levels of autophagy in intestinal macrophages and murine 
      BMDMs were increased under these IBD-related inflammatory challenges and CRH 
      further enhanced these effects. Subsequent administration of chloroquine markedly 
      attenuated the detrimental effects of CRH on IBD severity and inflammatory 
      reactions via inhibition of autophagy. These findings illustrate the effects of 
      peripheral administration of CRH on DSS-induced IBD via the enhancement of 
      intestinal macrophage autophagy, thus providing a novel understanding as well as 
      therapeutic target for the treatment of IBD.
CI  - (c) 2021. The Author(s).
FAU - Zhao, Sheng-Bing
AU  - Zhao SB
AUID- ORCID: 0000-0002-1922-451X
AD  - Department of Gastroenterology, Changhai Hospital, Second Military Medical 
      University/Naval Medical University, Shanghai, China.
FAU - Wu, Jia-Yi
AU  - Wu JY
AD  - Department of Gastroenterology, Changhai Hospital, Second Military Medical 
      University/Naval Medical University, Shanghai, China.
FAU - He, Zi-Xuan
AU  - He ZX
AD  - Department of Gastroenterology, Changhai Hospital, Second Military Medical 
      University/Naval Medical University, Shanghai, China.
FAU - Song, Yi-Hang
AU  - Song YH
AD  - Department of Gastroenterology, Changhai Hospital, Second Military Medical 
      University/Naval Medical University, Shanghai, China.
FAU - Chang, Xin
AU  - Chang X
AD  - Department of Gastroenterology, Changhai Hospital, Second Military Medical 
      University/Naval Medical University, Shanghai, China.
AD  - Department of Gastroenterology, General Hospital of Central Theater Command, 
      Wuhan, China.
FAU - Xia, Tian
AU  - Xia T
AD  - Department of Gastroenterology, Changhai Hospital, Second Military Medical 
      University/Naval Medical University, Shanghai, China.
FAU - Fang, Xue
AU  - Fang X
AD  - Department of Gastroenterology, Changhai Hospital, Second Military Medical 
      University/Naval Medical University, Shanghai, China.
FAU - Li, Zhao-Shen
AU  - Li ZS
AUID- ORCID: 0000-0003-0404-242X
AD  - Department of Gastroenterology, Changhai Hospital, Second Military Medical 
      University/Naval Medical University, Shanghai, China. li.zhaoshen@hotmail.com.
FAU - Xu, Can
AU  - Xu C
AUID- ORCID: 0000-0002-4544-7151
AD  - Department of Gastroenterology, Changhai Hospital, Second Military Medical 
      University/Naval Medical University, Shanghai, China. xxcc211@126.com.
FAU - Wang, Shu-Ling
AU  - Wang SL
AUID- ORCID: 0000-0001-9428-5569
AD  - Department of Gastroenterology, Changhai Hospital, Second Military Medical 
      University/Naval Medical University, Shanghai, China. wangshuling0000@126.com.
FAU - Bai, Yu
AU  - Bai Y
AUID- ORCID: 0000-0002-7577-6001
AD  - Department of Gastroenterology, Changhai Hospital, Second Military Medical 
      University/Naval Medical University, Shanghai, China. baiyu1998@hotmail.com.
LA  - eng
PT  - Journal Article
DEP - 20211207
PL  - United States
TA  - Cell Death Discov
JT  - Cell death discovery
JID - 101665035
PMC - PMC8648763
COIS- The authors declare no competing interests.
EDAT- 2021/12/08 06:00
MHDA- 2021/12/08 06:01
PMCR- 2021/12/07
CRDT- 2021/12/07 06:05
PHST- 2021/05/26 00:00 [received]
PHST- 2021/11/15 00:00 [accepted]
PHST- 2021/11/07 00:00 [revised]
PHST- 2021/12/07 06:05 [entrez]
PHST- 2021/12/08 06:00 [pubmed]
PHST- 2021/12/08 06:01 [medline]
PHST- 2021/12/07 00:00 [pmc-release]
AID - 10.1038/s41420-021-00767-8 [pii]
AID - 767 [pii]
AID - 10.1038/s41420-021-00767-8 [doi]
PST - epublish
SO  - Cell Death Discov. 2021 Dec 7;7(1):377. doi: 10.1038/s41420-021-00767-8.