PMID- 34874960
OWN - NLM
STAT- MEDLINE
DCOM- 20220106
LR  - 20220106
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 16
IP  - 12
DP  - 2021
TI  - ECMO use in Germany: An analysis of 29,929 ECMO runs.
PG  - e0260324
LID - 10.1371/journal.pone.0260324 [doi]
LID - e0260324
AB  - BACKGROUND: Extracorporeal Membrane Oxygenation (ECMO) use is increasing despite 
      limited evidence. The aim of this study was to demonstrate heterogeneity of ECMO 
      use and its association with hospital size and annual frequency in Germany. 
      METHODS: This is a database analysis of all ECMO cases in Germany from 2010 to 
      2016 using the German Diagnosis Related Groups (DRG) coding system for ECMO. 
      RESULTS: During the study period, 510 hospitals performed 29,929 ECMO runs 
      (12,572 vvECMO, 11,504 vaECMO, 1993 pECLA) with an increase over time. Mortality 
      ranged between 58% and 66% for vaECMO cases and 66% and 53% for vvECMO cases. 304 
      (61%) hospitals performed only one ECMO per year. 78%% of all ECMO runs were 
      performed in centres with more than 20 cases per year and more than half of all 
      ECMO runs were performed in hospitals with >1.000 beds. Mortality for vv and 
      vaECMO was highest in very small hospitals (< 200 beds; 70%; 74%) and very large 
      hospitals (>1000 beds; 60%; 62%). CONCLUSIONS: Use of ECMO is still increasing 
      and a substantial proportion of hospitals performs very few ECMO runs. Small 
      hospitals had a significantly higher mortality, but dependence on hospital size 
      and ECMO mortality was irregular.
FAU - Bercker, Sven
AU  - Bercker S
AD  - Department of Anesthesiology and Intensive Care Medicine, University of Leipzig 
      Medical Faculty, Leipzig, Germany.
FAU - Petroff, David
AU  - Petroff D
AUID- ORCID: 0000-0002-6916-1465
AD  - Clinical Trial Centre, University of Leipzig, Leipzig, Germany.
FAU - Polze, Nina
AU  - Polze N
AD  - Department of Anesthesiology and Intensive Care Medicine, University of Leipzig 
      Medical Faculty, Leipzig, Germany.
FAU - Karagianidis, Christian
AU  - Karagianidis C
AD  - Department of Pneumology and Critical Care Medicine, Cologne-Merheim Hospital, 
      ARDS and ECMO Centre, Kliniken der Stadt Koln gGmbH, Witten/Herdecke University 
      Hospital, Cologne, Germany.
FAU - Bein, Thomas
AU  - Bein T
AD  - Department of Anesthesiology and Critical Care Medicine, Faculty of Medicine, 
      University of Regensburg, Regensburg, Germany.
FAU - Laudi, Sven
AU  - Laudi S
AD  - Department of Anesthesiology and Intensive Care Medicine, University of Leipzig 
      Medical Faculty, Leipzig, Germany.
FAU - Stehr, Sebastian N
AU  - Stehr SN
AD  - Department of Anesthesiology and Intensive Care Medicine, University of Leipzig 
      Medical Faculty, Leipzig, Germany.
FAU - Voelker, Maria Theresa
AU  - Voelker MT
AUID- ORCID: 0000-0002-5267-5064
AD  - Department of Anesthesiology and Intensive Care Medicine, University of Leipzig 
      Medical Faculty, Leipzig, Germany.
LA  - eng
PT  - Journal Article
PT  - Observational Study
DEP - 20211207
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Databases, Factual
MH  - Diagnosis-Related Groups
MH  - Extracorporeal Membrane Oxygenation/mortality/*statistics & numerical data
MH  - Female
MH  - Germany/epidemiology
MH  - Health Facility Size
MH  - Hospital Mortality
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Retrospective Studies
MH  - Young Adult
PMC - PMC8651096
COIS- The authors have declared that no competing interests exist.
EDAT- 2021/12/08 06:00
MHDA- 2022/01/07 06:00
PMCR- 2021/12/07
CRDT- 2021/12/07 17:21
PHST- 2021/06/10 00:00 [received]
PHST- 2021/11/06 00:00 [accepted]
PHST- 2021/12/07 17:21 [entrez]
PHST- 2021/12/08 06:00 [pubmed]
PHST- 2022/01/07 06:00 [medline]
PHST- 2021/12/07 00:00 [pmc-release]
AID - PONE-D-21-19126 [pii]
AID - 10.1371/journal.pone.0260324 [doi]
PST - epublish
SO  - PLoS One. 2021 Dec 7;16(12):e0260324. doi: 10.1371/journal.pone.0260324. 
      eCollection 2021.