PMID- 34875255
OWN - NLM
STAT- MEDLINE
DCOM- 20220228
LR  - 20220531
IS  - 2213-3763 (Electronic)
IS  - 0019-4832 (Print)
IS  - 0019-4832 (Linking)
VI  - 74
IP  - 1
DP  - 2022 Jan-Feb
TI  - Association between serum netrin-1, netrin-4 and risk of the acute coronary 
      syndrome in patients with type 2 diabetes mellitus-A pilot study.
PG  - 72-75
LID - S0019-4832(21)00448-X [pii]
LID - 10.1016/j.ihj.2021.11.186 [doi]
AB  - The present study was done to assess the diagnostic utility of serum netrin-1 and 
      netrin-4 for recognising the acute coronary syndrome (ACS) in type 2 diabetes 
      mellitus (T2DM) patients. Forty-two T2DM patients with ACS (Cases) and forty-two 
      T2DM patients without ACS (Controls) were compared. Cases had lower serum 
      netrin-1 and netrin-4 levels than controls and were negatively associated with 
      creatinine kinase-total, creatinine kinase-MB, troponin-T and H-FABP. ROC 
      analysis showed that netrin-1 and netrin-4 had good sensitivity and specificity 
      for ACS prediction in T2DM patients. Serum netrin-1 and netrin-4 levels might be 
      considered complementary markers for ACS diagnosis in T2DM patients.
CI  - Copyright (c) 2021 Cardiological Society of India. Published by Elsevier, a 
      division of RELX India, Pvt. Ltd. All rights reserved.
FAU - Inderjeet, Kumar
AU  - Inderjeet K
AD  - Department of Biochemistry, Jawaharlal Institute of Postgraduate Medical 
      Education and Research, Pondicherry, India.
FAU - Adole, Prashant Shankarrao
AU  - Adole PS
AD  - Department of Biochemistry, Jawaharlal Institute of Postgraduate Medical 
      Education and Research, Pondicherry, India. Electronic address: 
      prashant.s@jipmer.edu.in.
FAU - Vinod, K V
AU  - Vinod KV
AD  - Department of Medicine, Jawaharlal Institute of Postgraduate Medical Education 
      and Research, Pondicherry, India.
FAU - Pillai, Ajith Ananthakrishna
AU  - Pillai AA
AD  - Department of Cardiology, Jawaharlal Institute of Postgraduate Medical Education 
      and Research, Pondicherry, India.
LA  - eng
PT  - Journal Article
DEP - 20211204
PL  - India
TA  - Indian Heart J
JT  - Indian heart journal
JID - 0374675
RN  - 0 (Biomarkers)
RN  - 0 (NTN1 protein, human)
RN  - 158651-98-0 (Netrin-1)
SB  - IM
MH  - *Acute Coronary Syndrome
MH  - Biomarkers
MH  - *Diabetes Mellitus, Type 2/complications/diagnosis
MH  - Humans
MH  - Netrin-1
MH  - Pilot Projects
MH  - ROC Curve
PMC - PMC8891007
OTO - NOTNLM
OT  - Acute coronary syndrome
OT  - Netrin-1
OT  - Netrin-4
OT  - Type 2 diabetes mellitus
EDAT- 2021/12/08 06:00
MHDA- 2022/03/01 06:00
PMCR- 2022/01/01
CRDT- 2021/12/07 20:12
PHST- 2021/06/04 00:00 [received]
PHST- 2021/09/28 00:00 [revised]
PHST- 2021/11/30 00:00 [accepted]
PHST- 2021/12/08 06:00 [pubmed]
PHST- 2022/03/01 06:00 [medline]
PHST- 2021/12/07 20:12 [entrez]
PHST- 2022/01/01 00:00 [pmc-release]
AID - S0019-4832(21)00448-X [pii]
AID - 10.1016/j.ihj.2021.11.186 [doi]
PST - ppublish
SO  - Indian Heart J. 2022 Jan-Feb;74(1):72-75. doi: 10.1016/j.ihj.2021.11.186. Epub 
      2021 Dec 4.