PMID- 34877820
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220319
IS  - 2578-5745 (Electronic)
IS  - 2578-5745 (Linking)
VI  - 4
IP  - 3
DP  - 2022 Mar
TI  - Cancer in Anti-Neutrophil Cytoplasm Antibody-Associated Vasculitis and 
      Polyarteritis Nodosa in Australia: A Population-Based Study.
PG  - 223-230
LID - 10.1002/acr2.11378 [doi]
AB  - OBJECTIVE: The study objective was to compare incident cancer rates among 
      patients with anti-neutrophil cytoplasm antibody-associated vasculitis (AAV) and 
      polyarteritis nodosa (PAN) in Western Australia (WA) with the general population 
      and perform time-varying analyses to identify periods with greatest excess 
      cancers. METHODS: Administrative health data from patients hospitalized with 
      incident AAV/PAN from 1980 to 2014 were linked to the WA cancer registry, which 
      holds compulsorily reported cancer data (excluding skin squamous cell and basal 
      cell carcinomas). Incident cancer rates in patients with AAV/PAN were compared 
      with age-, sex-, and calendar-year-matched WA population rates. RESULTS: Patients 
      with AAV/PAN had higher overall rates of incident cancer compared with the 
      matched population (standardized incidence ratio [SIR], 1.74; 95% confidence 
      interval [CI], 1.42-2.10). In subgroup analyses, incident cancer rates in 
      patients with granulomatosis with polyangiitis/eosinophilic granulomatosis with 
      polyangiitis were approximately double the general population (SIR, 2.21; 95% CI, 
      1.73-2.78) but similar to the general population in patients with microscopic 
      polyangiitis/PAN (SIR, 1.21; 95% CI, 0.85-1.68). Patients with AAV/PAN had higher 
      rates of genitourinary, skin, hematological, and lung cancers. Excess rates of 
      hematological and lung cancers peaked early after diagnosis, whereas excess skin 
      and genitourinary cancer rates peaked at 5 and 10 years, respectively. 
      CONCLUSION: This study highlights the importance of long-term cancer surveillance 
      in patients with AAV/PAN and defines time frames of excess risk for specific 
      cancers, which may help inform guidance on cancer screening. Furthermore, it 
      indicates the need for skin surveillance for melanoma in addition to nonmelanoma 
      skin cancers in patients who have greater environmental ultraviolet exposure, 
      such as in Australia.
CI  - (c) 2021 The Authors. ACR Open Rheumatology published by Wiley Periodicals LLC on 
      behalf of American College of Rheumatology.
FAU - Tieu, Joanna
AU  - Tieu J
AUID- ORCID: 0000-0002-2975-176X
AD  - Faculty of Health and Medical Sciences, University of Adelaide, Adelaide, 
      Australia.
AD  - Rheumatology Research Group, Basil Hetzel Institute, Adelaide, Australia.
AD  - Rheumatology Unit, The Queen Elizabeth Hospital, Adelaide, Australia.
AD  - Rheumatology Unit, Lyell McEwin Hospital, Adelaide, Australia.
FAU - Lester, Susan
AU  - Lester S
AUID- ORCID: 0000-0003-3013-2701
AD  - Faculty of Health and Medical Sciences, University of Adelaide, Adelaide, 
      Australia.
AD  - Rheumatology Research Group, Basil Hetzel Institute, Adelaide, Australia.
AD  - Rheumatology Unit, The Queen Elizabeth Hospital, Adelaide, Australia.
FAU - Raymond, Warren
AU  - Raymond W
AUID- ORCID: 0000-0002-2537-0070
AD  - Rheumatology Section, School of Medicine, University of Western Australia, Perth, 
      Australia.
FAU - Keen, Helen
AU  - Keen H
AUID- ORCID: 0000-0002-8469-2424
AD  - Rheumatology Section, School of Medicine, University of Western Australia, Perth, 
      Australia.
AD  - Rheumatology Department, Fiona Stanley Hospital, Perth, Australia.
FAU - Hill, Catherine L
AU  - Hill CL
AUID- ORCID: 0000-0001-8289-4922
AD  - Faculty of Health and Medical Sciences, University of Adelaide, Adelaide, 
      Australia.
AD  - Rheumatology Research Group, Basil Hetzel Institute, Adelaide, Australia.
AD  - Rheumatology Unit, The Queen Elizabeth Hospital, Adelaide, Australia.
AD  - Rheumatology Unit, Royal Adelaide Hospital, Adelaide, Australia.
FAU - Nossent, Johannes
AU  - Nossent J
AUID- ORCID: 0000-0002-2833-7997
AD  - Rheumatology Section, School of Medicine, University of Western Australia, Perth, 
      Australia.
AD  - Rheumatology Department, Sir Charles Gairdner Hospital, Perth, Australia.
LA  - eng
GR  - Arthritis Foundation of Western Australia/
GR  - Postgraduate scholarship/National Health and Medical Research Council/
PT  - Journal Article
DEP - 20211207
PL  - United States
TA  - ACR Open Rheumatol
JT  - ACR open rheumatology
JID - 101740025
PMC - PMC8916546
EDAT- 2021/12/09 06:00
MHDA- 2021/12/09 06:01
PMCR- 2021/12/07
CRDT- 2021/12/08 06:53
PHST- 2021/07/22 00:00 [revised]
PHST- 2021/03/10 00:00 [received]
PHST- 2021/06/10 00:00 [accepted]
PHST- 2021/12/09 06:00 [pubmed]
PHST- 2021/12/09 06:01 [medline]
PHST- 2021/12/08 06:53 [entrez]
PHST- 2021/12/07 00:00 [pmc-release]
AID - ACR211378 [pii]
AID - 10.1002/acr2.11378 [doi]
PST - ppublish
SO  - ACR Open Rheumatol. 2022 Mar;4(3):223-230. doi: 10.1002/acr2.11378. Epub 2021 Dec 
      7.