PMID- 34879788 OWN - NLM STAT- MEDLINE DCOM- 20220222 LR - 20220222 IS - 1477-0962 (Electronic) IS - 0961-2033 (Linking) VI - 30 IP - 14 DP - 2021 Dec TI - Air pollution influence on serum inflammatory interleukins: A prospective study in childhood-onset systemic lupus erythematous patients. PG - 2268-2275 LID - 10.1177/09612033211061479 [doi] AB - OBJECTIVE: To assess the effect of individual exposure, in real-time, to traffic-related pollutants on serum interleukin levels of childhood-onset lupus erythematous systemic (c-SLE) patients. METHODS: A longitudinal and observational design was conducted in 12 repeated measures of serum samples and clinical evaluations (totaling 108 measurements) of c-SLE patients over 30 consecutive months. Real-time, individual exposure to fine particles (PM(2.5)) and nitrogen dioxide (NO(2)) was measured with portable monitors. Generalized estimating equation was used to evaluate the association between exposure to PM(2.5) and NO(2) and the following serum cytokine levels on the 7 days preceding clinical assessment and serum collection: MCP1, IL-6, IL-8, IL-10, IL-17, IFN-alpha, and TNF-alpha. Disease activity and other risk factors were also controlled. RESULTS: An interquartile range (IQR) increase in PM(2.5) daily concentration was significantly associated with increased levels of TNF-alpha on the third, fourth, and seventh day after exposure; IL-10 on the third and fourth day after exposure; IL-17 on the third and seventh day after exposure; and INF-alpha on the third day after exposure (p < 0.05). An IQR increase in 7-day moving average of PM(2.5) was associated with a 6.2 pg/mL (95% CI: 0.5; 11.8; p = 0.04) increase in serum IFN-alpha level. An unexpected significant association was observed between an IQR increase in NO(2)7-day cumulative concentration and a decrease of 1.6 pg/mL (95% CI: -2.6; -0.7; p < 0.001) in serum IL-17. CONCLUSION: Real-time exposure to PM(2.5) prospectively associated with increased serum TNF-alpha, INF-alpha, IL-10, and IL-17 levels in c-SLE patients. FAU - Farhat, Sylvia Costa Lima AU - Farhat SCL AUID- ORCID: 0000-0003-4036-5226 AD - Environmental Epidemiology Study Group, Laboratory of Experimental Air Pollution, 37884Faculdade de Medicina da Universidade de Sao Paulo, Sao Paulo, Brazil. AD - Laboratory of Experimental Air Pollution, LIM05, Faculdade de Medicina FMUSP, 37884Universidade de Sao Paulo, Sao Paulo, Brazil. AD - Pediatric Department Hospital das Clinicas HCFMUSP, Faculdade de Medicina, 37884Universidade de Sao Paulo, Sao Paulo, Brazil. FAU - Ejnisman, Carolina AU - Ejnisman C AD - Environmental Epidemiology Study Group, Laboratory of Experimental Air Pollution, 37884Faculdade de Medicina da Universidade de Sao Paulo, Sao Paulo, Brazil. AD - 428062Universidade de Santo Amaro, Sao Paulo, Brazil. FAU - Alves, Andressa Guariento Ferreira AU - Alves AGF AD - Environmental Epidemiology Study Group, Laboratory of Experimental Air Pollution, 37884Faculdade de Medicina da Universidade de Sao Paulo, Sao Paulo, Brazil. FAU - Goulart, Maria Fernanda Giacomin AU - Goulart MFG AD - Environmental Epidemiology Study Group, Laboratory of Experimental Air Pollution, 37884Faculdade de Medicina da Universidade de Sao Paulo, Sao Paulo, Brazil. FAU - Lichtenfels, Ana Julia de Faria Coimbra AU - Lichtenfels AJFC AD - Laboratory of Experimental Air Pollution, LIM05, Faculdade de Medicina FMUSP, 37884Universidade de Sao Paulo, Sao Paulo, Brazil. FAU - Braga, Alfesio Luis Ferreira AU - Braga ALF AD - Environmental Epidemiology Study Group, Laboratory of Experimental Air Pollution, 37884Faculdade de Medicina da Universidade de Sao Paulo, Sao Paulo, Brazil. AD - Laboratory of Experimental Air Pollution, LIM05, Faculdade de Medicina FMUSP, 37884Universidade de Sao Paulo, Sao Paulo, Brazil. AD - Environmental Exposure and Risk Assessment Group, Collective Health Post-graduation Program, 67888Universidade Catolica de Santos, Santos, Brazil. FAU - Pereira, Luiz Alberto Amador AU - Pereira LAA AD - Environmental Epidemiology Study Group, Laboratory of Experimental Air Pollution, 37884Faculdade de Medicina da Universidade de Sao Paulo, Sao Paulo, Brazil. AD - Laboratory of Experimental Air Pollution, LIM05, Faculdade de Medicina FMUSP, 37884Universidade de Sao Paulo, Sao Paulo, Brazil. FAU - Maluf Elias, Adriana AU - Maluf Elias A AD - Pediatric Department Hospital das Clinicas HCFMUSP, Faculdade de Medicina, 37884Universidade de Sao Paulo, Sao Paulo, Brazil. AD - Pediatric Rheumatology Unit, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, 28133Universidade de Sao Paulo, Sao Paulo, Brazil. FAU - Silva, Clovis A AU - Silva CA AUID- ORCID: 0000-0001-9250-6508 AD - Pediatric Department Hospital das Clinicas HCFMUSP, Faculdade de Medicina, 37884Universidade de Sao Paulo, Sao Paulo, Brazil. AD - Pediatric Rheumatology Unit, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, 28133Universidade de Sao Paulo, Sao Paulo, Brazil. AD - Division of Rheumatology, Faculdade de Medicina FMUSP, 37884Universidade de Sao Paulo, Sao Paulo, Brazil. LA - eng PT - Journal Article DEP - 20211209 PL - England TA - Lupus JT - Lupus JID - 9204265 RN - 0 (Interferon-alpha) RN - 0 (Interleukin-17) RN - 0 (Particulate Matter) RN - 0 (Tumor Necrosis Factor-alpha) RN - 130068-27-8 (Interleukin-10) RN - S7G510RUBH (Nitrogen Dioxide) SB - IM MH - *Air Pollution/analysis MH - Humans MH - Interferon-alpha/immunology MH - Interleukin-10/immunology MH - Interleukin-17/immunology MH - *Lupus Erythematosus, Discoid MH - *Lupus Erythematosus, Systemic MH - Nitrogen Dioxide MH - Particulate Matter/adverse effects MH - Prospective Studies MH - Tumor Necrosis Factor-alpha OTO - NOTNLM OT - Childhood-systemic lupus erythematosus OT - air pollution OT - inhalable fine particles OT - real-time exposure OT - serum cytokines OT - traffic-related-pollution EDAT- 2021/12/10 06:00 MHDA- 2022/02/23 06:00 CRDT- 2021/12/09 05:28 PHST- 2021/12/10 06:00 [pubmed] PHST- 2022/02/23 06:00 [medline] PHST- 2021/12/09 05:28 [entrez] AID - 10.1177/09612033211061479 [doi] PST - ppublish SO - Lupus. 2021 Dec;30(14):2268-2275. doi: 10.1177/09612033211061479. Epub 2021 Dec 9.