PMID- 34880411
OWN - NLM
STAT- MEDLINE
DCOM- 20220427
LR  - 20230210
IS  - 1759-5053 (Electronic)
IS  - 1759-5045 (Linking)
VI  - 19
IP  - 3
DP  - 2022 Mar
TI  - Intra-pancreatic fat deposition: bringing hidden fat to the fore.
PG  - 153-168
LID - 10.1038/s41575-021-00551-0 [doi]
AB  - Development of advanced modalities for detection of fat within the pancreas has 
      transformed understanding of the role of intra-pancreatic fat deposition (IPFD) 
      in health and disease. There is now strong evidence for the presence of minimal 
      (but not negligible) IPFD in healthy human pancreas. Diffuse excess IPFD, or 
      fatty pancreas disease (FPD), is more frequent than type 2 diabetes mellitus 
      (T2DM) (the most common disease of the endocrine pancreas) and acute pancreatitis 
      (the most common disease of the exocrine pancreas) combined. FPD is not strictly 
      a function of high BMI; it can result from the excess deposition of fat in the 
      islets of Langerhans, acinar cells, inter-lobular stroma, acinar-to-adipocyte 
      trans-differentiation or replacement of apoptotic acinar cells. This process 
      leads to a wide array of diseases characterized by excess IPFD, including but not 
      limited to acute pancreatitis, chronic pancreatitis, pancreatic cancer, T2DM, 
      diabetes of the exocrine pancreas. There is ample evidence for FPD being 
      potentially reversible. Weight loss-induced decrease of intra-pancreatic fat is 
      tightly associated with remission of T2DM and its re-deposition with recurrence 
      of the disease. Reversing FPD will open up opportunities for preventing or 
      intercepting progression of major diseases of the exocrine pancreas in the 
      future.
CI  - (c) 2021. Springer Nature Limited.
FAU - Petrov, Maxim S
AU  - Petrov MS
AUID- ORCID: 0000-0002-5923-9062
AD  - School of Medicine, University of Auckland, Auckland, New Zealand. 
      max.petrov@gmail.com.
FAU - Taylor, Roy
AU  - Taylor R
AD  - Magnetic Resonance Centre, Translational and Clinical Research Institute, 
      Newcastle University, Newcastle upon Tyne, UK.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20211208
PL  - England
TA  - Nat Rev Gastroenterol Hepatol
JT  - Nature reviews. Gastroenterology & hepatology
JID - 101500079
SB  - IM
MH  - Acute Disease
MH  - *Diabetes Mellitus, Type 2
MH  - Humans
MH  - Pancreas
MH  - *Pancreatic Diseases/etiology
MH  - *Pancreatitis/etiology
EDAT- 2021/12/10 06:00
MHDA- 2022/04/28 06:00
CRDT- 2021/12/09 06:53
PHST- 2021/11/04 00:00 [accepted]
PHST- 2021/12/10 06:00 [pubmed]
PHST- 2022/04/28 06:00 [medline]
PHST- 2021/12/09 06:53 [entrez]
AID - 10.1038/s41575-021-00551-0 [pii]
AID - 10.1038/s41575-021-00551-0 [doi]
PST - ppublish
SO  - Nat Rev Gastroenterol Hepatol. 2022 Mar;19(3):153-168. doi: 
      10.1038/s41575-021-00551-0. Epub 2021 Dec 8.