PMID- 34881087
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20211224
IS  - 2152-5250 (Print)
IS  - 2152-5250 (Electronic)
IS  - 2152-5250 (Linking)
VI  - 12
IP  - 8
DP  - 2021 Dec
TI  - Bioenergetic Impairment in the Neuro-Glia-Vascular Unit: An Emerging 
      Physiopathology during Aging.
PG  - 2080-2095
LID - 10.14336/AD.2021.04017 [doi]
AB  - An emerging concept termed the "neuro-glia-vascular unit" (NGVU) has been 
      established in recent years to understand the complicated mechanism of 
      multicellular interactions among vascular cells, glial cells, and neurons. It has 
      been proverbially reported that the NGVU is significantly associated with 
      neurodegenerative disorders, such as Alzheimer's disease (AD), Parkinson's 
      disease (PD), and amyotrophic lateral sclerosis (ALS). Physiological aging is an 
      inevitable progression associated with oxidative damage, bioenergetic 
      alterations, mitochondrial dysfunction, and neuroinflammation, which is partially 
      similar to the pathology of AD. Thus, senescence is regarded as the background 
      for the development of neurodegenerative diseases. With the exacerbation of 
      global aging, senescence is an increasingly serious problem in the medical field. 
      In this review, the coupling of each component, including neurons, glial cells, 
      and vascular cells, in the NGVU is described in detail. Then, various mechanisms 
      of age-dependent impairment in each part of the NGVU are discussed. Moreover, the 
      potential bioenergetic alterations between different cell types in the NGVU are 
      highlighted, which seems to be an emerging physiopathology associated with the 
      aged brain. Bioenergetic intervention in the NGVU may be a new direction for 
      studies on delaying or diminishing aging in the future.
CI  - Copyright: (c) 2021 Yuan et al.
FAU - Yuan, Minghao
AU  - Yuan M
AD  - 1Department of Neurology, Chongqing General Hospital, University of Chinese 
      Academy of Sciences, Chongqing, 400013, Chongqing, China.
AD  - 2Chongqing School, University of Chinese Academy of Sciences, Chongqing, China.
AD  - 3Chongqing Key Laboratory of Neurodegenerative Diseases, Chongqing, 400013, 
      Chongqing, China.
AD  - 4Chongqing Medical University, Chongqing, China.
FAU - Wang, Yangyang
AU  - Wang Y
AD  - 1Department of Neurology, Chongqing General Hospital, University of Chinese 
      Academy of Sciences, Chongqing, 400013, Chongqing, China.
AD  - 3Chongqing Key Laboratory of Neurodegenerative Diseases, Chongqing, 400013, 
      Chongqing, China.
FAU - Wang, Shengyuan
AU  - Wang S
AD  - 1Department of Neurology, Chongqing General Hospital, University of Chinese 
      Academy of Sciences, Chongqing, 400013, Chongqing, China.
AD  - 2Chongqing School, University of Chinese Academy of Sciences, Chongqing, China.
AD  - 3Chongqing Key Laboratory of Neurodegenerative Diseases, Chongqing, 400013, 
      Chongqing, China.
AD  - 4Chongqing Medical University, Chongqing, China.
FAU - Huang, Zhenting
AU  - Huang Z
AD  - 1Department of Neurology, Chongqing General Hospital, University of Chinese 
      Academy of Sciences, Chongqing, 400013, Chongqing, China.
AD  - 3Chongqing Key Laboratory of Neurodegenerative Diseases, Chongqing, 400013, 
      Chongqing, China.
FAU - Jin, Feng
AU  - Jin F
AD  - 1Department of Neurology, Chongqing General Hospital, University of Chinese 
      Academy of Sciences, Chongqing, 400013, Chongqing, China.
AD  - 2Chongqing School, University of Chinese Academy of Sciences, Chongqing, China.
AD  - 3Chongqing Key Laboratory of Neurodegenerative Diseases, Chongqing, 400013, 
      Chongqing, China.
FAU - Zou, Qian
AU  - Zou Q
AD  - 1Department of Neurology, Chongqing General Hospital, University of Chinese 
      Academy of Sciences, Chongqing, 400013, Chongqing, China.
AD  - 3Chongqing Key Laboratory of Neurodegenerative Diseases, Chongqing, 400013, 
      Chongqing, China.
FAU - Li, Jing
AU  - Li J
AD  - 1Department of Neurology, Chongqing General Hospital, University of Chinese 
      Academy of Sciences, Chongqing, 400013, Chongqing, China.
AD  - 3Chongqing Key Laboratory of Neurodegenerative Diseases, Chongqing, 400013, 
      Chongqing, China.
FAU - Pu, Yinshuang
AU  - Pu Y
AD  - 1Department of Neurology, Chongqing General Hospital, University of Chinese 
      Academy of Sciences, Chongqing, 400013, Chongqing, China.
AD  - 3Chongqing Key Laboratory of Neurodegenerative Diseases, Chongqing, 400013, 
      Chongqing, China.
FAU - Cai, Zhiyou
AU  - Cai Z
AD  - 1Department of Neurology, Chongqing General Hospital, University of Chinese 
      Academy of Sciences, Chongqing, 400013, Chongqing, China.
AD  - 2Chongqing School, University of Chinese Academy of Sciences, Chongqing, China.
AD  - 3Chongqing Key Laboratory of Neurodegenerative Diseases, Chongqing, 400013, 
      Chongqing, China.
AD  - 4Chongqing Medical University, Chongqing, China.
LA  - eng
GR  - R01 NS079792/NS/NINDS NIH HHS/United States
PT  - Journal Article
PT  - Review
DEP - 20211201
PL  - United States
TA  - Aging Dis
JT  - Aging and disease
JID - 101540533
PMC - PMC8612602
OTO - NOTNLM
OT  - aging
OT  - energy metabolism
OT  - neuro-glia-vascular unit
COIS- Conflict of interest None declared.
EDAT- 2021/12/10 06:00
MHDA- 2021/12/10 06:01
PMCR- 2021/12/01
CRDT- 2021/12/09 07:03
PHST- 2021/03/14 00:00 [received]
PHST- 2021/04/17 00:00 [accepted]
PHST- 2021/12/09 07:03 [entrez]
PHST- 2021/12/10 06:00 [pubmed]
PHST- 2021/12/10 06:01 [medline]
PHST- 2021/12/01 00:00 [pmc-release]
AID - ad-12-8-2080 [pii]
AID - 10.14336/AD.2021.04017 [doi]
PST - epublish
SO  - Aging Dis. 2021 Dec 1;12(8):2080-2095. doi: 10.14336/AD.2021.04017. eCollection 
      2021 Dec.