PMID- 34881317
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230921
IS  - 2297-1769 (Print)
IS  - 2297-1769 (Electronic)
IS  - 2297-1769 (Linking)
VI  - 8
DP  - 2021
TI  - Effects of FecB Mutation on Estrus, Ovulation, and Endocrine Characteristics in 
      Small Tail Han Sheep.
PG  - 709737
LID - 10.3389/fvets.2021.709737 [doi]
LID - 709737
AB  - The Booroola fecundity gene (FecB) has a mutation that was found to increase the 
      ovulation rate and litter size in Booroola Merino sheep. This mutation is also 
      associated with the fecundity of small-tail han (STH) sheep, an important 
      maternal breed used to produce hybrid offspring for mutton production in China. 
      Previous research showed that the FecB gene affects reproduction in STH sheep, 
      based on litter size records. However, the effects of this gene on estrus, 
      ovulation, and endocrine characteristics in these sheep remain unclear. Here, we 
      analyzed the traits mentioned earlier and compared them among the three FecB 
      genotypes of STH ewes using estrus synchronization. Overall, 53 pluriparous ewes 
      were selected from among 890 STH ewes and subjected to FecB genotyping for 
      experiments to characterize estrous and ovulation rates. FecB heterozygous (+B) 
      ewes presented an earlier onset of estrus (42.9 +/- 2.2 h) and a shorter estrous 
      cycle (17.2 +/- 0.2 days) (P </= 0.05). The ovulation rates increased with the 
      increasing copy number of the B allele (P </= 0.01). Ovulation time showed no 
      significant differences among the three FecB genotypes. The serum concentrations 
      of follicle-stimulating hormone (FSH), luteinizing hormone, estrogen (E(2)), and 
      progesterone (P(4)) were measured in 19 of the ewes. Serum concentrations of E(2) 
      and FSH dramatically varied around the time of behavioral estrus. In FecB mutant 
      homozygous (BB) ewes, E(2) concentration had two peaks, which were higher (P </= 
      0.05) than those of ++ genotypes. FSH concentration of BB ewes was higher (P </= 
      0.05) than that of the ++ ewes just after estrus. The expression of the estrogen 
      receptor 1 (ESR1) gene in the +B genotype was higher than in the other genotypes. 
      Based on the data for the reproductive performance of STH ewes with the three 
      FecB genotypes, our study suggests that the development of follicles in ewes with 
      the B allele is dependent on the response to FSH regulated by E(2) in the early 
      stage. +B ewes, exhibiting moderate ovulation and litter size and a shorter 
      estrous cycle, can be highly recommended in sheep crossbreeding systems for 
      commercial mutton production. Moreover, this study provides useful information to 
      conserve better and use the genetic resources of STH sheep in China.
CI  - Copyright (c) 2021 Wang, Guo, He, Liu, Di, Hu, Cao, Zhang, Zhang and Chu.
FAU - Wang, Xiangyu
AU  - Wang X
AD  - Key Laboratory of Animal Genetics, Breeding and Reproduction of Ministry of 
      Agriculture and Rural Affairs, Institute of Animal Science, Chinese Academy of 
      Agricultural Sciences, Beijing, China.
FAU - Guo, Xiaofei
AU  - Guo X
AD  - Institute of Animal Husbandry and Veterinary Medicine, Tianjin Academy of 
      Agricultural Sciences, Tianjin, China.
FAU - He, Xiaoyun
AU  - He X
AD  - Key Laboratory of Animal Genetics, Breeding and Reproduction of Ministry of 
      Agriculture and Rural Affairs, Institute of Animal Science, Chinese Academy of 
      Agricultural Sciences, Beijing, China.
FAU - Liu, Qiuyue
AU  - Liu Q
AD  - Institute of Genetics and Developmental Biology, The Innovation Academy for Seed 
      Design, Chinese Academy of Sciences, Beijing, China.
FAU - Di, Ran
AU  - Di R
AD  - Key Laboratory of Animal Genetics, Breeding and Reproduction of Ministry of 
      Agriculture and Rural Affairs, Institute of Animal Science, Chinese Academy of 
      Agricultural Sciences, Beijing, China.
FAU - Hu, Wenping
AU  - Hu W
AD  - Key Laboratory of Animal Genetics, Breeding and Reproduction of Ministry of 
      Agriculture and Rural Affairs, Institute of Animal Science, Chinese Academy of 
      Agricultural Sciences, Beijing, China.
FAU - Cao, Xiaohan
AU  - Cao X
AD  - Key Laboratory of Animal Genetics, Breeding and Reproduction of Ministry of 
      Agriculture and Rural Affairs, Institute of Animal Science, Chinese Academy of 
      Agricultural Sciences, Beijing, China.
FAU - Zhang, Xiaosheng
AU  - Zhang X
AD  - Institute of Animal Husbandry and Veterinary Medicine, Tianjin Academy of 
      Agricultural Sciences, Tianjin, China.
FAU - Zhang, Jinlong
AU  - Zhang J
AD  - Institute of Animal Husbandry and Veterinary Medicine, Tianjin Academy of 
      Agricultural Sciences, Tianjin, China.
FAU - Chu, Mingxing
AU  - Chu M
AD  - Key Laboratory of Animal Genetics, Breeding and Reproduction of Ministry of 
      Agriculture and Rural Affairs, Institute of Animal Science, Chinese Academy of 
      Agricultural Sciences, Beijing, China.
LA  - eng
PT  - Journal Article
DEP - 20211122
PL  - Switzerland
TA  - Front Vet Sci
JT  - Frontiers in veterinary science
JID - 101666658
PMC - PMC8646036
OTO - NOTNLM
OT  - FecB gene
OT  - estrus
OT  - hormone receptors
OT  - ovulation
OT  - reproduction hormones
OT  - sheep
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2021/12/10 06:00
MHDA- 2021/12/10 06:01
PMCR- 2021/01/01
CRDT- 2021/12/09 07:05
PHST- 2021/05/14 00:00 [received]
PHST- 2021/10/08 00:00 [accepted]
PHST- 2021/12/09 07:05 [entrez]
PHST- 2021/12/10 06:00 [pubmed]
PHST- 2021/12/10 06:01 [medline]
PHST- 2021/01/01 00:00 [pmc-release]
AID - 10.3389/fvets.2021.709737 [doi]
PST - epublish
SO  - Front Vet Sci. 2021 Nov 22;8:709737. doi: 10.3389/fvets.2021.709737. eCollection 
      2021.