PMID- 34882724
OWN - NLM
STAT- MEDLINE
DCOM- 20220110
LR  - 20221207
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 16
IP  - 12
DP  - 2021
TI  - HLA polymorphisms and risk of glioblastoma in Koreans.
PG  - e0260618
LID - 10.1371/journal.pone.0260618 [doi]
LID - e0260618
AB  - PURPOSE: Immune responses for cancer cells can be altered according to genetic 
      variation of human leukocyte antigen (HLA). Association of HLA polymorphism with 
      risk of various cancer types is well known. However, the association between HLA 
      and glioblastoma (GBM) remains uncertain. We sought to evaluate the association 
      of HLA polymorphism with risk of GBM development in Koreans. MATERIALS AND 
      METHODS: A case-control study was performed to identify the odds ratios (OR) of 
      HLA class I and II genes for GBM. The control group consisted of 142 healthy 
      Korean volunteers, and the GBM group was 80 patients with newly diagnosed GBM at 
      our institution. HLA class I (-A, -B, and-C) and class II (-DR, -DQ, and-DP) 
      genotyping was performed by high-resolution polymerase chain reaction 
      (PCR)-sequence-based typing (PCR-SBT) methods. RESULTS: There were significantly 
      decreased frequencies of HLA-A*26:02 (OR 0.22 CI 0.05-0.98), HLA-C*08:01 (OR 0.29 
      CI 0.10-0.87), and HLA-DRB1*08:03 (OR 0.32 CI 0.11-0.98), while there was 
      significantly increased frequency of HLA-C*04:01 (OR 2.29 CI 1.05-4.97). In 
      analysis of haplotypes, the frequency of DRB1*14:05-DQB1*05:03 was significantly 
      decreased (OR 0.22 CI 0.05-0.98). CONCLUSION: This study suggests that genetic 
      variations of HLA may affect GBM development in Koreans. Further investigations 
      with larger sample sizes are needed to delineate any potential role of the HLA 
      polymorphisms in the pathogenesis of GBM development.
FAU - Choi, Sang-Soo
AU  - Choi SS
AD  - Department of Neurosurgery, Seoul St. Mary's Hospital, College of Medicine, The 
      Catholic University of Korea, Seoul, South Korea.
FAU - Choi, Haeyoun
AU  - Choi H
AD  - Department of Microbiology, College of Medicine, The Catholic University of 
      Korea, Seoul, South Korea.
FAU - Baek, In-Cheol
AU  - Baek IC
AUID- ORCID: 0000-0003-3630-3364
AD  - Catholic Hematopoietic Stem Cell Bank, College of Medicine, The Catholic 
      University of Korea, Seoul, South Korea.
FAU - Park, Soon A
AU  - Park SA
AD  - Department of Biomedicine and Health Sciences, College of Medicine, The Catholic 
      University of Korea, Seoul, South Korea.
FAU - Park, Jae-Sung
AU  - Park JS
AUID- ORCID: 0000-0002-9827-9913
AD  - Department of Neurosurgery, Seoul St. Mary's Hospital, College of Medicine, The 
      Catholic University of Korea, Seoul, South Korea.
FAU - Kim, Tai-Gyu
AU  - Kim TG
AD  - Department of Microbiology, College of Medicine, The Catholic University of 
      Korea, Seoul, South Korea.
AD  - Department of Biomedicine and Health Sciences, College of Medicine, The Catholic 
      University of Korea, Seoul, South Korea.
FAU - Jeun, Sin-Soo
AU  - Jeun SS
AD  - Department of Neurosurgery, Seoul St. Mary's Hospital, College of Medicine, The 
      Catholic University of Korea, Seoul, South Korea.
FAU - Ahn, Stephen
AU  - Ahn S
AUID- ORCID: 0000-0002-6854-1597
AD  - Department of Neurosurgery, Seoul St. Mary's Hospital, College of Medicine, The 
      Catholic University of Korea, Seoul, South Korea.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20211209
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
RN  - 0 (HLA-A Antigens)
RN  - 0 (HLA-C Antigens)
RN  - 0 (HLA-DRB1 Chains)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Asian People/*genetics
MH  - Case-Control Studies
MH  - Female
MH  - Genetic Association Studies
MH  - Genotyping Techniques
MH  - Glioblastoma/*genetics
MH  - HLA-A Antigens/*genetics
MH  - HLA-C Antigens/*genetics
MH  - HLA-DRB1 Chains/*genetics
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Polymorphism, Single Nucleotide
MH  - Republic of Korea
MH  - Young Adult
PMC - PMC8659341
COIS- The authors declare no conflicts of interest.
EDAT- 2021/12/10 06:00
MHDA- 2022/01/11 06:00
PMCR- 2021/12/09
CRDT- 2021/12/09 17:30
PHST- 2021/05/19 00:00 [received]
PHST- 2021/11/13 00:00 [accepted]
PHST- 2021/12/09 17:30 [entrez]
PHST- 2021/12/10 06:00 [pubmed]
PHST- 2022/01/11 06:00 [medline]
PHST- 2021/12/09 00:00 [pmc-release]
AID - PONE-D-21-16588 [pii]
AID - 10.1371/journal.pone.0260618 [doi]
PST - epublish
SO  - PLoS One. 2021 Dec 9;16(12):e0260618. doi: 10.1371/journal.pone.0260618. 
      eCollection 2021.