PMID- 34883265
OWN - NLM
STAT- MEDLINE
DCOM- 20220407
LR  - 20220407
IS  - 1549-9642 (Electronic)
IS  - 1549-9634 (Linking)
VI  - 40
DP  - 2022 Feb
TI  - Fe(3)O(4)@polydopamine nanoparticle-loaded human umbilical cord mesenchymal stem 
      cells improve the cognitive function in Alzheimer's disease mice by promoting 
      hippocampal neurogenesis.
PG  - 102507
LID - S1549-9634(21)00150-7 [pii]
LID - 10.1016/j.nano.2021.102507 [doi]
AB  - One of the most promising treatments for neurodegenerative diseases is the stem 
      cell therapy; however, there are still some limitations in the treatment of 
      Alzheimer's disease. In this study, superparamagnetic nanoparticles composed of 
      magnetic Fe(3)O(4) and polydopamine shells were used to label human umbilical 
      cord mesenchymal stem cells (hUC-MSCs) in order to increase the targeting of 
      hUC-MSCs. Our data suggested that Fe(3)O(4)@PDA labeling increase the efficiency 
      of hUC-MSCs entering the brain. Moreover, the water maze test showed that 
      compared with hUC-MSCs only, Fe(3)O(4)@PDA-labeled hUC-MSCs improved the 
      cognitive ability of APP/PS1 transgenic mice more significantly. Other 
      experimental data showed that the expression of essential proteins in the 
      hippocampus, such as Abeta, synaptophysin, brain-derived neurotrophic factor, are 
      affected by Fe(3)O(4)@PDA coated-hUC-MSCs. The regulation of Fe(3)O(4)@PDA 
      coated-hUC-MSCs could improve the memory and cognitive ability of AD mice by 
      excessive generation of neuroprotective factors, which might be considered a 
      viable therapy to treat AD.
CI  - Copyright (c) 2021 Elsevier Inc. All rights reserved.
FAU - Wang, Yuxiang
AU  - Wang Y
AD  - Edmond H. Fischer Signal Transduction Laboratory, College of Life Sciences, Jilin 
      University, Changchun, China.
FAU - Jiang, Jinlan
AU  - Jiang J
AD  - Scientific Research Centre of China-Japan Union Hospital, Jilin University, 
      Changchun, China.
FAU - Fu, Xueqi
AU  - Fu X
AD  - Edmond H. Fischer Signal Transduction Laboratory, College of Life Sciences, Jilin 
      University, Changchun, China.
FAU - Zhang, Jingtian
AU  - Zhang J
AD  - College of Chinese Medicinal Materials, Jilin Agricultural University, Changchun, 
      Jilin, China.
FAU - Song, Jiayue
AU  - Song J
AD  - Edmond H. Fischer Signal Transduction Laboratory, College of Life Sciences, Jilin 
      University, Changchun, China.
FAU - Wang, Yu
AU  - Wang Y
AD  - Edmond H. Fischer Signal Transduction Laboratory, College of Life Sciences, Jilin 
      University, Changchun, China.
FAU - Duan, Lian
AU  - Duan L
AD  - Scientific Research Centre of China-Japan Union Hospital, Jilin University, 
      Changchun, China.
FAU - Shao, Pu
AU  - Shao P
AD  - Scientific Research Centre of China-Japan Union Hospital, Jilin University, 
      Changchun, China.
FAU - Xu, Xuemin
AU  - Xu X
AD  - Department of Biology, College of Arts and Sciences, University of Texas of the 
      Permian Basin, Odessa, TX, USA.
FAU - Zeng, Linlin
AU  - Zeng L
AD  - Edmond H. Fischer Signal Transduction Laboratory, College of Life Sciences, Jilin 
      University, Changchun, China. Electronic address: zenglinlin@jlu.edu.cn.
FAU - Zhang, Fuqiang
AU  - Zhang F
AD  - Scientific Research Centre of China-Japan Union Hospital, Jilin University, 
      Changchun, China. Electronic address: zfqzhang@jlu.edu.cn.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20211206
PL  - United States
TA  - Nanomedicine
JT  - Nanomedicine : nanotechnology, biology, and medicine
JID - 101233142
RN  - 0 (Indoles)
RN  - 0 (Polymers)
RN  - 0 (polydopamine)
SB  - IM
MH  - *Alzheimer Disease/therapy
MH  - Animals
MH  - Cell Differentiation/physiology
MH  - Cognition
MH  - Hippocampus
MH  - Humans
MH  - Indoles
MH  - *Mesenchymal Stem Cell Transplantation
MH  - *Mesenchymal Stem Cells/physiology
MH  - Mice
MH  - Mice, Transgenic
MH  - *Nanoparticles
MH  - Neurogenesis
MH  - Polymers
MH  - Umbilical Cord
OTO - NOTNLM
OT  - Alzheimer's disease
OT  - Human umbilical cord mesenchymal stem cells
OT  - cognitive function
OT  - hippocampal neurogenesis
EDAT- 2021/12/10 06:00
MHDA- 2022/04/08 06:00
CRDT- 2021/12/09 20:16
PHST- 2021/03/14 00:00 [received]
PHST- 2021/11/16 00:00 [revised]
PHST- 2021/11/17 00:00 [accepted]
PHST- 2021/12/10 06:00 [pubmed]
PHST- 2022/04/08 06:00 [medline]
PHST- 2021/12/09 20:16 [entrez]
AID - S1549-9634(21)00150-7 [pii]
AID - 10.1016/j.nano.2021.102507 [doi]
PST - ppublish
SO  - Nanomedicine. 2022 Feb;40:102507. doi: 10.1016/j.nano.2021.102507. Epub 2021 Dec 
      6.