PMID- 34883773 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20240404 IS - 2073-4360 (Electronic) IS - 2073-4360 (Linking) VI - 13 IP - 23 DP - 2021 Dec 6 TI - Expanding Poly(lactic acid) (PLA) and Polyhydroxyalkanoates (PHAs) Applications: A Review on Modifications and Effects. LID - 10.3390/polym13234271 [doi] LID - 4271 AB - The high price of petroleum, overconsumption of plastic products, recent climate change regulations, the lack of landfill spaces in addition to the ever-growing population are considered the driving forces for introducing sustainable biodegradable solutions for greener environment. Due to the harmful impact of petroleum waste plastics on human health, environment and ecosystems, societies have been moving towards the adoption of biodegradable natural based polymers whose conversion and consumption are environmentally friendly. Therefore, biodegradable biobased polymers such as poly(lactic acid) (PLA) and polyhydroxyalkanoates (PHAs) have gained a significant amount of attention in recent years. Nonetheless, some of the vital limitations to the broader use of these biopolymers are that they are less flexible and have less impact resistance when compared to petroleum-based plastics (e.g., polypropylene (PP), high-density polyethylene (HDPE) and polystyrene (PS)). Recent advances have shown that with appropriate modification methods-plasticizers and fillers, polymer blends and nanocomposites, such limitations of both polymers can be overcome. This work is meant to widen the applicability of both polymers by reviewing the available materials on these methods and their impacts with a focus on the mechanical properties. This literature investigation leads to the conclusion that both PLA and PHAs show strong candidacy in expanding their utilizations to potentially substitute petroleum-based plastics in various applications, including but not limited to, food, active packaging, surgical implants, dental, drug delivery, biomedical as well as antistatic and flame retardants applications. FAU - Naser, Ahmed Z AU - Naser AZ AUID- ORCID: 0000-0002-6334-5925 AD - School of Engineering, University of Guelph, Guelph, ON N1G 2W1, Canada. FAU - Deiab, Ibrahim AU - Deiab I AD - School of Engineering, University of Guelph, Guelph, ON N1G 2W1, Canada. FAU - Defersha, Fantahun AU - Defersha F AD - School of Engineering, University of Guelph, Guelph, ON N1G 2W1, Canada. FAU - Yang, Sheng AU - Yang S AUID- ORCID: 0000-0002-6286-2779 AD - School of Engineering, University of Guelph, Guelph, ON N1G 2W1, Canada. LA - eng PT - Journal Article PT - Review DEP - 20211206 PL - Switzerland TA - Polymers (Basel) JT - Polymers JID - 101545357 PMC - PMC8659978 OTO - NOTNLM OT - 3D printing OT - degradation OT - fillers OT - plasticizers OT - poly(lactic acid) (PLA) OT - polyhydroxyalkanoates (PHAs) OT - polymer blends OT - polymer nanocomposites OT - properties OT - review OT - sustainability COIS- The authors declare no conflict of interest. EDAT- 2021/12/11 06:00 MHDA- 2021/12/11 06:01 PMCR- 2021/12/06 CRDT- 2021/12/10 01:01 PHST- 2021/11/05 00:00 [received] PHST- 2021/11/25 00:00 [revised] PHST- 2021/11/30 00:00 [accepted] PHST- 2021/12/10 01:01 [entrez] PHST- 2021/12/11 06:00 [pubmed] PHST- 2021/12/11 06:01 [medline] PHST- 2021/12/06 00:00 [pmc-release] AID - polym13234271 [pii] AID - polymers-13-04271 [pii] AID - 10.3390/polym13234271 [doi] PST - epublish SO - Polymers (Basel). 2021 Dec 6;13(23):4271. doi: 10.3390/polym13234271.