PMID- 34884337
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20240819
IS  - 2077-0383 (Print)
IS  - 2077-0383 (Electronic)
IS  - 2077-0383 (Linking)
VI  - 10
IP  - 23
DP  - 2021 Nov 29
TI  - Oral Antibiotic Prophylaxis Lowers Surgical Site Infection in Elective Colorectal 
      Surgery: Results of a Pragmatic Cohort Study in Catalonia.
LID - 10.3390/jcm10235636 [doi]
LID - 5636
AB  - BACKGROUND: The role of oral antibiotic prophylaxis (OAP) and mechanical bowel 
      preparation (MBP) in the prevention of surgical site infection (SSI) after 
      colorectal surgery is still controversial. The aim of this study was to analyze 
      the effect of a bundle including both measures in a National Infection 
      Surveillance Network in Catalonia. METHODS: Pragmatic cohort study to assess the 
      effect of OAP and MBP in reducing SSI rate in 65 hospitals, comparing baseline 
      phase (BP: 2007-2015) with implementation phase (IP: 2016-2019). To compare the 
      results, a logistic regression model was established. RESULTS: Out of 34,421 
      colorectal operations, 5180 had SSIs (15.05%). Overall SSI rate decreased from 
      18.81% to 11.10% in BP and IP, respectively (OR 0.539, CI(95) 0.507-0.573, p < 
      0.0001). Information about bundle implementation was complete in 61.7% of cases. 
      In a univariate analysis, OAP and MBP were independent factors in decreasing 
      overall SSI, with OR 0.555, CI(95) 0.483-0.638, and OR 0.686, CI(95) 0.589-0.798, 
      respectively; and similarly, organ/space SSI (O/S-SSI) (OR 0.592, CI(95) 
      0.494-0.710, and OR 0.771, CI(95) 0.630-0.944, respectively). However, only OAP 
      retained its protective effect at both levels at multivariate analyses. 
      CONCLUSIONS: oral antibiotic prophylaxis decreased the rates of SSI and O/S-SSI 
      in a large series of elective colorectal surgery.
FAU - Badia, Josep M
AU  - Badia JM
AUID- ORCID: 0000-0003-2928-5233
AD  - Department of Surgery, Hospital General Granollers, 08348 Granollers, Barcelona, 
      Spain.
AD  - School of Medicine, Universitat Internacional de Catalunya, 08195 Sant Cugat del 
      Valles, Barcelona, Spain.
FAU - Flores-Yelamos, Miriam
AU  - Flores-Yelamos M
AD  - Department of Surgery, Hospital General Granollers, 08348 Granollers, Barcelona, 
      Spain.
AD  - School of Medicine, Universitat Internacional de Catalunya, 08195 Sant Cugat del 
      Valles, Barcelona, Spain.
FAU - Vazquez, Ana
AU  - Vazquez A
AD  - Servei d'Estadistica Aplicada, Universitat Autonoma de Barcelona, 08193 
      Bellaterra, Barcelona, Spain.
FAU - Arroyo-Garcia, Nares
AU  - Arroyo-Garcia N
AD  - Department of Surgery, Hospital General Granollers, 08348 Granollers, Barcelona, 
      Spain.
AD  - School of Medicine, Universitat Internacional de Catalunya, 08195 Sant Cugat del 
      Valles, Barcelona, Spain.
FAU - Puig-Asensio, Mireia
AU  - Puig-Asensio M
AD  - Department of Infectious Diseases, Hospital Universitari de Bellvitge, Spanish 
      Network for Research in Infectious Diseases (REIPI RD16/0016/0005), 08907 
      L'Hospitalet del Llobregat, Barcelona, Spain.
FAU - Pares, David
AU  - Pares D
AD  - Department of Surgery, Hospital Universitari Germans Trias i Pujol, 08916 
      Badalona, Barcelona, Spain.
FAU - Pera, Miguel
AU  - Pera M
AD  - Department of Surgery, Hospital del Mar, 08003 Barcelona, Catalonia, Spain.
FAU - Lopez-Contreras, Joaquin
AU  - Lopez-Contreras J
AUID- ORCID: 0000-0002-3166-4016
AD  - Infectious Disease Unit, Hospital de la Santa Creu i Sant Pau-Institut 
      d'Investigacio Biomedica Sant Pau, 08041 Barcelona, Barcelona, Spain.
FAU - Limon, Enric
AU  - Limon E
AUID- ORCID: 0000-0002-5396-1521
AD  - VINCat Program, 08028 Barcelona, Catalonia, Spain.
AD  - Universitat de Barcelona, 08007 Barcelona, Catalonia, Spain.
FAU - Pujol, Miquel
AU  - Pujol M
AD  - Department of Infectious Diseases, Hospital Universitari de Bellvitge, Spanish 
      Network for Research in Infectious Diseases (REIPI RD16/0016/0005), 08907 
      L'Hospitalet del Llobregat, Barcelona, Spain.
AD  - VINCat Program, 08028 Barcelona, Catalonia, Spain.
FAU - Members Of The VINCat Colorectal Surveillance Team
AU  - Members Of The VINCat Colorectal Surveillance Team
LA  - eng
PT  - Journal Article
DEP - 20211129
PL  - Switzerland
TA  - J Clin Med
JT  - Journal of clinical medicine
JID - 101606588
PMC - PMC8658297
OTO - NOTNLM
OT  - colorectal surgery
OT  - mechanical bowel preparation
OT  - oral antibiotic prophylaxis
OT  - preventative measures
OT  - surgical site infection
OT  - surgical wound infection
COIS- The authors declare no conflict of interest.
EDAT- 2021/12/11 06:00
MHDA- 2021/12/11 06:01
PMCR- 2021/11/29
CRDT- 2021/12/10 01:03
PHST- 2021/10/20 00:00 [received]
PHST- 2021/11/26 00:00 [revised]
PHST- 2021/11/26 00:00 [accepted]
PHST- 2021/12/10 01:03 [entrez]
PHST- 2021/12/11 06:00 [pubmed]
PHST- 2021/12/11 06:01 [medline]
PHST- 2021/11/29 00:00 [pmc-release]
AID - jcm10235636 [pii]
AID - jcm-10-05636 [pii]
AID - 10.3390/jcm10235636 [doi]
PST - epublish
SO  - J Clin Med. 2021 Nov 29;10(23):5636. doi: 10.3390/jcm10235636.