PMID- 34887185
OWN - NLM
STAT- MEDLINE
DCOM- 20220314
LR  - 20220314
IS  - 1873-460X (Electronic)
IS  - 1056-8727 (Linking)
VI  - 36
IP  - 1
DP  - 2022 Jan
TI  - Fetuin-A to adiponectin ratio is an independent indicator of subclinical 
      atherosclerosis in patients with newly diagnosed type 2 diabetes mellitus.
PG  - 108102
LID - S1056-8727(21)00326-3 [pii]
LID - 10.1016/j.jdiacomp.2021.108102 [doi]
AB  - AIMS: The purpose of this research was to explore the associations of fetuin-A, 
      adiponectin, and fetuin-A/adiponectin ratio (F/A ratio) with subclinical 
      atherosclerosis as evaluated by carotid intima-media thickness (CIMT) in cases 
      with newly diagnosed type 2 diabetes mellitus (T2DM). METHODS: A total of 283 
      newly diagnosed T2DM patients were enrolled in this study. Serum fetuin-A and 
      adiponectin levels were determined with an ELISA method. Other clinical and 
      biochemical parameters were also collected. RESULTS: Significant linear increases 
      in waist-to-hip ratio (WHR), systolic blood pressure (SBP), diastolic blood 
      pressure, homoeostasis model assessment of insulin resistance, C-reactive protein 
      (CRP) and F/A ratio, and a significant linear decrease in adiponectin with 
      increasing tertiles of CIMT were observed (P for trends <0.05). However, no 
      significant correlation between fetuin-A and CIMT was detected (P > 0.05). In 
      multivariate logistic regression models, WHR, SBP and F/A ratio were 
      independently correlated with higher CIMT. Receiver operating characteristic 
      curve analysis indicated that F/A ratio had a better predictive power for higher 
      CIMT than adiponectin and fetuin-A, with an area under the curve of 0.802, 0.713 
      and 0.646, respectively. CONCLUSION: F/A ratio is an independent indicator of 
      subclinical atherosclerosis in patients with newly diagnosed T2DM.
CI  - Copyright (c) 2021 Elsevier Inc. All rights reserved.
FAU - Zhou, Zhongwei
AU  - Zhou Z
AD  - Department of Clinical Laboratory, Yancheng Third People's Hospital (The Sixth 
      Affiliated Hospital of Nantong University), Jiangsu 224001, China.
FAU - Chen, Hongmei
AU  - Chen H
AD  - Department of Clinical Laboratory, Yancheng Third People's Hospital (The Sixth 
      Affiliated Hospital of Nantong University), Jiangsu 224001, China.
FAU - Sun, Mingzhong
AU  - Sun M
AD  - Department of Clinical Laboratory, Yancheng Third People's Hospital (The Sixth 
      Affiliated Hospital of Nantong University), Jiangsu 224001, China.
FAU - Jin, Hao
AU  - Jin H
AD  - Department of Blood Transfusion, Yancheng Third People's Hospital (The Sixth 
      Affiliated Hospital of Nantong University), Yancheng, Jiangsu 224001, China.
FAU - Ju, Huixiang
AU  - Ju H
AD  - Department of Clinical Laboratory, Yancheng Third People's Hospital (The Sixth 
      Affiliated Hospital of Nantong University), Jiangsu 224001, China. Electronic 
      address: jhxycsy@163.com.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20211203
PL  - United States
TA  - J Diabetes Complications
JT  - Journal of diabetes and its complications
JID - 9204583
RN  - 0 (Adiponectin)
RN  - 0 (alpha-2-HS-Glycoprotein)
SB  - IM
MH  - Adiponectin
MH  - *Atherosclerosis/complications/diagnosis
MH  - Carotid Intima-Media Thickness
MH  - *Diabetes Mellitus, Type 2/complications/diagnosis
MH  - Humans
MH  - Risk Factors
MH  - alpha-2-HS-Glycoprotein
OTO - NOTNLM
OT  - Adiponectin
OT  - Carotid intima-media thickness
OT  - Fetuin-A
OT  - Fetuin-A/adiponectin ratio
OT  - Subclinical atherosclerosis
OT  - Type 2 diabetes mellitus
EDAT- 2021/12/11 06:00
MHDA- 2022/03/15 06:00
CRDT- 2021/12/10 05:51
PHST- 2021/09/08 00:00 [received]
PHST- 2021/10/31 00:00 [revised]
PHST- 2021/11/29 00:00 [accepted]
PHST- 2021/12/11 06:00 [pubmed]
PHST- 2022/03/15 06:00 [medline]
PHST- 2021/12/10 05:51 [entrez]
AID - S1056-8727(21)00326-3 [pii]
AID - 10.1016/j.jdiacomp.2021.108102 [doi]
PST - ppublish
SO  - J Diabetes Complications. 2022 Jan;36(1):108102. doi: 
      10.1016/j.jdiacomp.2021.108102. Epub 2021 Dec 3.